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Testicular germ cell tumours (TGCT) exhibit remarkable ability to differentiate into virtually all somatic tissue types. In this study, we investigated changes in mucin-type O-glycosylation, which have been associated with somatic cell differentiation and cancer. Expression profile of simple mucin-type O-glycans (Tn, sialyl-Tn, T), histo-blood group H and A variants and six polypeptide Ga1NAc-tran
Dynamic models complement existing time series of observations and static critical load calculations by simulating past and future development of chemistry in forest and lake ecosystems. They are used for dynamic assessment of the acidification and to produce target load functions, that describe what combinations of nitrogen and sulfur emission reductions are needed to achieve a chemical or biolog
Ectomycorrhizal (EM) fungi are known to colonize minerals in forest soil, and in many laboratory experiments it has been confirmed that EM fungi stimulate dissolution of minerals such as apatite, biotite and feldspars. However, due to the low number of experiments performed in the field, and in forests with different soil fertilities, it is difficult to conclude whether this effect has any ecologi
Depth data and bathymetry maps are used to analyze their association with tides, winds, currents and wave conditions in the port of Talara, at the coast of northern Peru. The objective is to investigate the processes that influence the sediment transport in the port. The sedimentation affects the saltwater pumps for fire fighting, obstructing them from delivering water since their operational wate
The idea of energy efficient, healthy buildings has existed since 1970s. However, a one-dimensional approach for many housing issues does not assure sustainability. Therefore, near the end of the 20th century, the built environment became a focus of attention within the environmental movement with wider focus on building certification schemes and sustainability issues such as interrelationships be
Strukturella och petrologiska studier av komplext veckade mafiskt- och felsiskt varvade sekvenser har genomförts i den paraautoktona delen av Svekonorvegiska provinsen i sydvästra Sverige. Tre deformationsfaser (D1, D2, D3) innefattande minst två veckfaser (F2, F3) och två lineationsfaser (L2, L3) karakteriserar ett flerfasigt veck i migmatiserad och mycket kompetent granatamfibolit. Denna enhet vStructural and petrological studies on complexly folded mafic and felsic layered sequences have been mapped in the parautochthonous basement of the Sveconorwegian Province, Sweden. Three deformation phases (D1, D2, D3)involving at least two fold phases (F2, F3) and two lineation phases (L2, L3) characterize a polyphase fold, which is primarily defined by a migmatized and highly competent garnet am
On their route to tropical Africa, European trans-Saharan migrants must cross two major geographical barriers, the Mediterranean Sea and the Sahara Desert, which necessitates the accumulation of large fuel loads. While northern Africa is the chief region where most migrants gain fuel for the Sahara crossing, Iberia is a target area to gain fuel before the sea crossing existing between Europe and A
Background. Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous group of B-cell lymphomas. Five clinical adverse risk factors are merged into the International Prognostic Index (IPI), which is the major tool for prognostication. In contrast to Hodgkin's lymphoma, gender is not considered as an adverse risk factor for DLBCL patients. As we clinically had observed a very good survival rate in y
P>Aims Type 1 diabetes mellitus (T1DM) is an autoimmune disease with potential mechanistic links to immune-related cancers. We aimed at examining the overall and specific cancer risks among hospitalized T1DM patients from the national registers in Sweden. Methods A T1DM research cohort was created by identifying T1DM patients from the Hospital Discharge Register and linking them with the Cancer Re
Background: Alzheimer's disease (AD) is associated with deposition of amyloid beta (A beta) in the brain, which is reflected by low concentration of the A beta 1-42 peptide in the cerebrospinal fluid (CSF). There are at least 15 additional A beta peptides in human CSF and their relative abundance pattern is thought to reflect the production and degradation of A beta. Here, we test the hypothesis t
BACKGROUND: Galectins, a family of small carbohydrate binding proteins, have been implicated in regulation of inflammatory reactions, including asthma and fibrosis in the lungs. Galectins are found in cells of the airways and in airway secretions, but their glycoprotein ligands there have only been studied to a very limited extent. METHODS: Bronchoalveolar lavage (BAL) fluid from mild asthmatics a
This thesis aimed to investigate possibilities to utilize death certificates in cancer epidemiology by analyzing nationwide databases from Sweden. Excessive information is available when investigating causes of death in cancer patients, including comorbidities and metastatic patterns. We used the Swedish Family- Cancer Database, which includes data from e.g. the Cause of Death Register and the Can
In order to describe the influence of Pleistocene glaciations on the genetic structure and demography of a highly mobile, but specialized, passerine, the Savi’s Warbler (Locustella luscinioides), mitochondrial DNA sequences (ND2) and microsatellites were analysed in c.330 individuals of 17 breeding and two wintering populations. Phylogenetic, population genetics and coalescent methods were used to
Atherosclerosis is a chronic inflammatory disease and the leading cause of myocardial infarction and stroke. Accumulation, aggregation and subsequent oxidation of LDL in the arterial wall are considered as key events in the development of atherosclerosis. The oxidation of LDL generates reactive aldehydes, including malondialdehyde (MDA) that modifies ApoB in LDL. Immune responses against MDA-modif
Our study had three objectives: to extend the plasmid-based transformation protocol to a clinical isolate of C. trachomatis belonging to the trachoma biovar, to provide "proof of principle'' that it is possible to "knock out'' selected plasmid genes (retaining a replication competent plasmid) and to investigate the plasticity of the plasmid. A recently developed, plasmid-based transformation proto
The aim of the present study was to analyse quantitatively, on a cat gastrocnemius preparation in vivo, the effects of i.a. or i.v. administered glyceryl trinitrate (GTN), sodium nitroprusside (SNP) or nitric oxide (NO dissolved in saline) on vascular resistance (tone) in the following consecutive vascular sections: Large-bore arterial resistance vessels (> 25 microns), small arterioles (< 25 micr
Popular Abstract in Swedish Protein kinas C (PKC) är en familj serin/treonin kinaser som har en viktig roll i regleringen av olika funktioner i cellen. PKC kan delas in i klassiska (alpha, betaI, betaII and gamma), nya (delta, epsilon, eta and theta) och atypiska (zeta and iota/lambda) isoformer beroende på skillnader i hur de regleras. När PKCalpha är inaktivt bidrar intramolekylära bindningar tiMembers of the protein kinase C (PKC) family of serine/threonine kinases play critical roles in cellular regulation. Depending on differences in regulation, PKCs can be divided into classical (alpha, betaI, betaII and gamma), novel (delta, epsilon, eta and theta) and atypical (zeta and iota/lambda) isoforms. When PKCalpha is inactive it is maintained in a closed conformation by intramolecular inte
