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Horizontal gene transfer (HGT) is a major driver of evolution and a key source of innovation in the microbial world. Mobile genetic elements (MGEs), such as plasmids and phages, often act as agents of HGT or as vehicles for cargo genes, some of which define the adaptive potential of the host organism in specific environments. These genes are involved in immunity, anti-immunity, virulence, and anti
The Chicxulub impact triggered a massive extinction event marked by the Cretaceous-Paleogene boundary (K-Pg ∼66Ma), ejecting vast amounts of dust, molten, and vaporized materials. While impact spherules are interpreted as products of impactor and target lithologies, their precise composition and distribution remain insufficiently constrained. Although previous studies restrict impactor contaminati
Extreme weather events pose significant threats to urban health in low- and middle-income countries, particularly in sub-Saharan Africa where there are systemic health challenges. This paper investigates health system vulnerabilities associated with flooding and extreme heat, along with strategies for resilience building by service providers and community members, in Accra and Tamale, Ghana. We em
OBJECTIVES: To investigate the mechanisms of platelet kinetics in the SMART study that demonstrated excess mortality with CD4 guided episodic antiretroviral therapy (ART) (drug conservation [DC]) compared to continuous treatment (viral suppression [VS]). Follow up analyses of stored plasma samples demonstrated increased activation of both inflammatory and coagulation pathways after stopping ART.
Genes encoding B lineage–restricted transcription factors are frequently mutated in B-lymphoid leukemias, suggesting a close link between normal and malignant B-cell development. One of these transcription factors is early B-cell factor 1 (EBF1), a protein of critical importance for lineage specification and survival of B-lymphoid progenitors. Here, we report that impaired EBF1 function in mouse B
As the demand for eco-friendly alternatives to traditional plastics grows, Polyethylene Furanoate (PEF) emerges as a promising solution. Derived from renewable biomass sources, PEF embodies sustainability principles by reducing reliance on finite resources and minimizing environmental impact. PEF is synthesized from 2,5-furandicarboxylic acid (FDCA), a key monomer which upon polymerization has the
Miljöpåverkan är ett ständigt återkommande ämne i samhällsdebatten. Många företag strävar efter att minimera sin miljöpåverkan, vilket kan ske genom att återanvända material i stället för att producera nya. I fallet med betongproduktion finns det flera sätt att göra den bättre för miljön. Till exempel kan rivningstegel användas som alternativ till den traditionella ballasten, som ett sätt att mins
I Sverige finns många förorenade områden med klorerade lösningsmedel och Färgaren 3 i Kris-tianstad är ett av dem. Där har tidigare legat en kemtvätt som använt sig av PCE (Tetrakloreten), där spill och läck-age har förorenat stora delar av fastigheten. PCE och dess metaboliter har en tendens att förorena stora volymer, vilket gör dessa ämnen svåra att sanera. Detta mastersarbete inriktar sig på a
The complexity of climate change creates a need for multifunctional solutions. Urban farming is a tool with potential for adapting and transitioning society. While not a new phenomenon, the incentives have changed and therefore contemporary characteristics for urban farming need to be further examined. This study analyzes how urban farms are valued and central barriers together with drivers. Opera
This thesis analyses ten indepth interviews on domestic workers, class and gender roles with ten young, politically inclined and often adamantly feminist women towards the upper end of the Indian class spectrum. It aims to deepen the understanding of employerworker relations and gendered domestic roles in contemporary Indian households. Previous literature on the middletoupper class employers of d
A large share of the existing building stock in Sweden originates from the so-called Million Building Programme, a large-scale construction wave between 1965 and 1974 to tackle the housing shortage at this time. Those buildings have very high energy demand and require renovation due to age and often neglected maintenance. The Swedish government’s long-term climate and energy goals are tied to an e
The coastal city of Kalmar is known as an attractive summer destination, both locally and internationally. The coast has long been included as one of the municipality’s priority goals. In its city development vision, the municipality strives to utilize the coast and take it into consideration in urban planning. On the other hand, Kalmar has a historic character, which is visible through its urban
Global warming and climate change is getting a serious issue and a great environmental threat that affects many aspects of life and our ways of living on this planet. The negative effects of climate change are endangering our communities, health and economy. Global warming can be considered as a main reason for sea rising levels, extreme heat which is responsible for many forests’ fires, severe dr
Streptococcus pneumoniae (pneumococcus) is a pathogen that causes severe local and life-threatening invasive diseases, which are associated with high mortality rates. Pneumococci have evolved several strategies to evade the host immune system, including complement to disseminate and to survive in various host niches. Thus, pneumococci bind complement inhibitors such as C4b-binding protein (C4BP) a
This paper introduces a research project with the aim to develop concepts and tools for architectural design, taking the ideas of "behaviour settings" as a starting point, to enable a more relevant holistic view in object oriented design of buildings. In this paper we introduce the concept of "architectural object" as a representation of a real "situation" involving people, behaviour, experience a
