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Neuronal cell suspensions prepared from the ventral mesencephalon and the septal-diagonal band area of rat embryos were implanted into the depth of the intact neostriatum or hippocampus of 21-23 month old female rats. Graft survival, assessed 3-4 months after grafting, was comparable to that seen in our previous studies of young adult recipients. Fibre outgrowth into the host brain was evaluated i
Thymidine labelling indices (LI) and the number of clonal chromosome aberrations were assessed in fine‐needle aspirates from enlarged lymph nodes in 22 patients with non‐Hodgkin's lymphoma (NHL). 11 patients had LI > 3.0 (median 8.4) and 11 others had LI < 3.0 (median 1.0). Three categories of chromosome aberration were recorded: normal karyotype, 1–5 aberrations, and ≥ 6 aberrations or multiple c
Molecular mechanics combined with Poisson-Boltzmann or generalized Born and solvent-accessible area solvation energies (MM/PBSA and MM/GBSA) are popular methods to estimate the free energy for the binding of small molecules to biomacromolecules. However, the estimation of the entropy has been problematic and time-consuming. Traditionally, normal-mode analysis has been used to estimate the entropy,
Bax is a well-known universal proapoptotic protein. Bax protein is detected in almost all human organs, and its expression levels can be correlated with disease progression and therapeutic efficacy in certain settings. Interestingly, increasing evidence has shown that mature neuronal cell death is often not typical apoptosis. Most results on the expression of Bax proteins (predominantly Baxα) in t
Popular Abstract in Swedish Interndosimetri ur ett makroskopiskt och mikroskopiskt perspektiv Med interndosimetri menas den metod man använder för att bestämma en absorberad dos till en vävnad för ett radioaktivt ämne som är fördelat i kroppen. Absorberad dos, dvs den av strålningen deponerade energin per massenhet, mäts i enheten gray (1 J/kg = 1 Gy) och kan beräknas med ekvationerna som syns påInternal dosimetry deals with the assessment of absorbed dose for radionuclides distributed inside the body. The absorbed dose is in its turn used for correlation with the biological effect caused by the irradiation. In radioimmunotherapy is however the correlation not easily found and factors influencing this are evaluated and discussed in this work. The internal dosimetry could be subdivided int
Extreme meteorological events are projected to increase in both frequency and intensity as climate change progresses, placing greater demands on accurate hydrological modelling for flood risk assessment and infrastructure design. In Sweden, the process-based S-HYPE model is widely used to simulate streamflow across approximately 26340 catchments, but like many regional rainfall-runoff models it sy
Elastic fibers containing elastin play an important role in tendon functionality, but the knowledge on presence and function of elastin during tendon healing is limited. The aim of this study was to investigate elastin content and distribution in intact and healing Achilles tendons and to understand how elastin influence the viscoelastic properties of tendons. The right Achilles tendon was complet
Popular Abstract in Swedish Varje år diagnostiseras över 50 000 nya cancerfall i Sverige varav drygt hälften botas. Sedan början på 1970-talet har cancer blivit allt vanligare. Ökningen beror delvis på att vi blivit allt äldre - cancer är en ålderssjukdom. Dödligheten har däremot varit ganska konstant under en längre tid eftersom diagnostik och behandling av cancer har förbättrats. De vanligaste Cancer is one of the main causes of death in the world, particularly in developing countries and is considered as a major public health problem. Radiation therapy has been an important modality for treatment of cancer for many decades. It can be used as a sole treatment modality or in combination with for example surgery, chemotherapy, hormone therapy and/or immune therapy. It has been calculated
Lathund inför disputation Soc io log iska ins t i tu t ionen Från slutseminarium till disputation – för doktoranden För blanketter och mer detaljerad information om tryckning, spikning etc., se Samhällsvetenskapliga fakultetens hemsida. https://www.sam.lu.se/internt/forska- och-utbilda/forskarutbildning/disputation Slutseminarium Samtliga avhandlingsmanus vid sociologiska institutionen ska behandl
https://www.soc.lu.se/sites/soc.lu.se/files/2025-02/Lathund_infor_disputation_Doktorander_20241211.pdf - 2026-09-24
Windahl SH, Andersson N, Chagin AS, Martensson UEA, Carlsten H, Olde B, Swanson C, Moverare-Skrtic S, Savendahl L, Lager-quist MK, Leeb-Lundberg LMF, Ohlsson C. The role of the G protein-coupled receptor GPR30 in the effects of estrogen in ovariectomized mice. Am J Physiol Endocrinol Metab 296: E490-E496, 2009. First published December 23, 2008; doi:10.1152/ajpendo.90691.2008.-In vitro studies sug
Microstructure and crystallographic texture are the key factors that determine the properties of sputtering target used in integrated circuit fabrication. Multi-pass clock-rolling has been used recently to produce Ta sputtering targets. However, the effect of strain per pass, or the number of passes to achieve desired thickness, in clock-rolling on the homogeneity of final microstructure has not b
Platelet-derived growth factor (PDGF) beta-receptor expression in normal and rheumatoid synovia was investigated by double immunofluorescence staining of frozen sections and by in situ hybridization. In the inflamed synovia, PDGF beta-receptor mRNA was present in vascular cells, as well as in discrete stromal cells. PDGF beta-receptor expressing cells in rheumatoid synovia were characterized by do
BACKGROUND: It is generally argued that variations in cerebral blood flow create concomitant changes in the cerebral blood volume (CBV). Because nitrous oxide (N(2)O) inhalation both increases cerebral blood flow and may increase intracranial pressure, it is reasonable to assume that N(2)O acts as a general vasodilatator in cerebral vessels both on the arterial and on the venous side. The aim of t
Popular Abstract in Swedish Lokal behandling med målsättning att förstöra kroppsvävnad genom uppvärmning (termoterapi) kan i vissa fall vara ett alternativ eller komplement till kirurgi. I avhandlingen presenteras utrustning och metoder för att, utifrån en fysikalisk synvinkel, göra sådana behandlingar säkrare och effektivare. Genom att beräkna temperaturefördelningen m.h.a. datorsimuleringar kan Local treatment with the aim to destruct tissue by heating (thermotherapy) may in some cases be an alternative or complement to surgical methods, and has gained increased interest during the last decade. The major advantage of these, often minimally-invasive methods, is that the disease can be controlled with reduced treatment trauma and complications. The extent of thermal damage is a complex fun
Brain edema associated with severe chronic hypertension was studied in stroke-prone spontaneously hypertensive rats (SHRSP), 5 to 9 months of age. Blood-brain barrier (BBB) leakage sites and intracerebral spreading pathways for plasma proteins were delineated by an intravenously (i.v.) injected exogenous dye tracer (Evans blue), known to form a complex with albumin in blood, and by immunohistochem
This work aims to evaluate the predictive strength of the relative seriality, parallel and Lyman-Kutcher-Burman (LKB) normal tissue complication probability (NTCP) models regarding the incidence of radiation pneumonitis (RP), in a group of patients following lung cancer radiotherapy and also to examine their correlation with pulmonary function tests (PFTs). The study was based on 47 patients who r
Both within the EU and within other regions/countries, there is a need to measure and monitor the well-being/Quality of Life (QoL) of people, in order to identify, anticipate, and address potential social or economic problems, at national and regional levels. This study presents a model to quantitatively estimate the spatial well-being (QoL) distribution across the EU-28 member states down to the
Fastighetsköpet är ett mycket speciellt köp i det avseendet att fastighetens egenskaper, skick och förhållanden i övrigt varierar avsevärt från fall till fall. Detta kan bero på många olika faktorer, exempelvis var fastigheten är belägen, för vilket ändamål fastigheten tidigare har använts, hur gammal den är, vem som har uppfört dess byggnad eller vilka framtida planer som finns för fastighetens oThe purchase of property is a special acquisition in the sense that the quality, shape and condition of the property in general vary considerably from case to case. This may be due to many different factors, for example, where the property is located, to which purpose the property has previously been used for, how old it is, who has built its structure or what future plans exist for the property&#
Penalty shootouts have become paradigmatic for research on anticipatory skills and decision making. The present study examines the dynamics of goal side selection when viewing realistic images depicting a penalty kick scenario. A sample of participants (n=40) was drawn from a population of students from Lund University. Participants viewed realistic images of a goalkeeper, soccer goal, and ball pl
Most people in the world and about a fifth of all school-aged Americans speak at least two languages. Nevertheless, little is known about second language (L2) processing in development, even though language proficiency is strongly related to success in almost all domains. Whereas behavioral studies of L2 acquisition in children are abundant, neurocognitive studies of L2 processing typically are li
