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The paper explores the impact of El Niño-Southern Oscillation (ENSO) on rainy season precipitation properties over the Yangtze River Basin. The multi-scale moving t-test was used to determine the onset and withdrawal of the rainy season. Results showed the following: (1) Onset and withdrawal of the averaged rainy season over the Yangtze River Basin showed a similar distribution and both progressed
Popular Abstract in Swedish Svetsning är en av de viktigaste tillämpningarna för robotar är inom tillverkningsindustrin. Normalt så programmeras roboten genom att operatören guidar manuellt robotarmen mellan de olika robotkoordinaterna. För att förbättra noggrannheten vid programmeringen kan man använda ett simuleringsverktyg, så kallat Computer Aided Robotics (CAR). Simulering kan även vara ett kThe objective of this thesis is to develop a simulation tool and a method by which robot trajectories, temperature histories, residual stresses and distortion can be analysed and optimized off-line. This was performed by integrating robot simulation software with finite element analysis software. A special interface was created which facilitated information exchange between the two software progra
To determine the functions of fibromodulin (Fmod), a small leucine-rich keratan sulfate proteoglycan in tooth formation, we investigated the distribution of Fmod in dental tissues by immunohistochemistry and characterized the dental phenotype of 1-day-old Fmod-deficient mice using light and transmission electron microscopy. Immunohistochemistry was also used to compare the relative protein express
In the pursuit of more sustainable urban energy systems, recovering industrial waste heat presents a promising opportunity to enhance energy efficiency and reduce emissions. This thesis explores the technical and economic feasibility of capturing excess heat from an industrial process and repurposing it to supply a new low-temperature district heating network planned for a new residential district
In diagnostic nuclear medicine, the biokinetics of the radiopharmaceutical (actually of the radionuclide) is determined for a number of representative patients. At therapy, it is essential to determine the patient's individual biokinetics of the radiopharmaceutical in order to calculate the absorbed doses to critical normal organs/tissues and to the target volume(s) with high accuracy. For the dia
Bax is a well-known universal proapoptotic protein. Bax protein is detected in almost all human organs, and its expression levels can be correlated with disease progression and therapeutic efficacy in certain settings. Interestingly, increasing evidence has shown that mature neuronal cell death is often not typical apoptosis. Most results on the expression of Bax proteins (predominantly Baxα) in t
Molecular mechanics combined with Poisson-Boltzmann or generalized Born and solvent-accessible area solvation energies (MM/PBSA and MM/GBSA) are popular methods to estimate the free energy for the binding of small molecules to biomacromolecules. However, the estimation of the entropy has been problematic and time-consuming. Traditionally, normal-mode analysis has been used to estimate the entropy,
Neuronal cell suspensions prepared from the ventral mesencephalon and the septal-diagonal band area of rat embryos were implanted into the depth of the intact neostriatum or hippocampus of 21-23 month old female rats. Graft survival, assessed 3-4 months after grafting, was comparable to that seen in our previous studies of young adult recipients. Fibre outgrowth into the host brain was evaluated i
We present particle tracking microrheology results on human mucins, isolated from normal surface and gland mucosa and one tumor sample, and examine the motility of Helicobacter pylori in these mucins. At 1.5% concentration human mucin solutions are purely viscous, with viscosity η (gland mucin) > η (surface mucin) > η (tumor mucin). In the presence of motile H. pylori bacteria, particle diffusion
Popular Abstract in Swedish Specifik språkstörning är ett tillstånd som kännetecknas av en avvikande tal- och språkstörning hos ett i övrigt friskt och normalutvecklat barn. Tillståndet beror således inte på en allmänt försenad utveckling, hörselnedsättning, uppenbar neurologisk eller psykisk sjukdom. Ofta har flera familjemedlemmar varit sena i sin tal- och språkutveckling eller har läs- och skriSpecific language impairment (SLI) is commonly described as a condition where a child with otherwise normal development and hearing does not acquire language as expected. Children with SLI often have a family history of language disorders. The aetiology is poorly understood. In the first two studies, event-related brain potentials(ERPs)evoked in response to tone- and to speech stimuli were record
Popular Abstract in Swedish Interndosimetri ur ett makroskopiskt och mikroskopiskt perspektiv Med interndosimetri menas den metod man använder för att bestämma en absorberad dos till en vävnad för ett radioaktivt ämne som är fördelat i kroppen. Absorberad dos, dvs den av strålningen deponerade energin per massenhet, mäts i enheten gray (1 J/kg = 1 Gy) och kan beräknas med ekvationerna som syns påInternal dosimetry deals with the assessment of absorbed dose for radionuclides distributed inside the body. The absorbed dose is in its turn used for correlation with the biological effect caused by the irradiation. In radioimmunotherapy is however the correlation not easily found and factors influencing this are evaluated and discussed in this work. The internal dosimetry could be subdivided int
Popular Abstract in Swedish POPULÄRVETENSKAPLIG SAMMANFATTNING (Popularized summary in Swedish) Monoaminer Monoaminer såsom serotonin, dopamin, noradrenalin, adrenalin och histamin är alla signalsubstanser syntetiserade från enkla aminosyror. Nervceller som innehåller monoaminer är anatomiskt lokaliserade till hjärnstammen och förlängda märgen. Härifrån försörjer de resten av storhjärnan samt ryIn the present study, the mRNA encoding the serotonin transporter (5-HTT) and two isoforms of the vesicular monoamine transporters (VMAT1 and VMAT2) have been mapped in the rat throughout gestation and early postnatal development using in situ hybridization, RT PCR and immunohistochemistry. 5-HTT mRNA was found in serotonergic neurons and VMAT2 mRNA in all monoaminergic neurons from early gestatio
Popular Abstract in Swedish Varje år diagnostiseras över 50 000 nya cancerfall i Sverige varav drygt hälften botas. Sedan början på 1970-talet har cancer blivit allt vanligare. Ökningen beror delvis på att vi blivit allt äldre - cancer är en ålderssjukdom. Dödligheten har däremot varit ganska konstant under en längre tid eftersom diagnostik och behandling av cancer har förbättrats. De vanligaste Cancer is one of the main causes of death in the world, particularly in developing countries and is considered as a major public health problem. Radiation therapy has been an important modality for treatment of cancer for many decades. It can be used as a sole treatment modality or in combination with for example surgery, chemotherapy, hormone therapy and/or immune therapy. It has been calculated
Elastic fibers containing elastin play an important role in tendon functionality, but the knowledge on presence and function of elastin during tendon healing is limited. The aim of this study was to investigate elastin content and distribution in intact and healing Achilles tendons and to understand how elastin influence the viscoelastic properties of tendons. The right Achilles tendon was complet
Extreme meteorological events are projected to increase in both frequency and intensity as climate change progresses, placing greater demands on accurate hydrological modelling for flood risk assessment and infrastructure design. In Sweden, the process-based S-HYPE model is widely used to simulate streamflow across approximately 26340 catchments, but like many regional rainfall-runoff models it sy
Windahl SH, Andersson N, Chagin AS, Martensson UEA, Carlsten H, Olde B, Swanson C, Moverare-Skrtic S, Savendahl L, Lager-quist MK, Leeb-Lundberg LMF, Ohlsson C. The role of the G protein-coupled receptor GPR30 in the effects of estrogen in ovariectomized mice. Am J Physiol Endocrinol Metab 296: E490-E496, 2009. First published December 23, 2008; doi:10.1152/ajpendo.90691.2008.-In vitro studies sug
This work aims to evaluate the predictive strength of the relative seriality, parallel and Lyman-Kutcher-Burman (LKB) normal tissue complication probability (NTCP) models regarding the incidence of radiation pneumonitis (RP), in a group of patients following lung cancer radiotherapy and also to examine their correlation with pulmonary function tests (PFTs). The study was based on 47 patients who r
Platelet-derived growth factor (PDGF) beta-receptor expression in normal and rheumatoid synovia was investigated by double immunofluorescence staining of frozen sections and by in situ hybridization. In the inflamed synovia, PDGF beta-receptor mRNA was present in vascular cells, as well as in discrete stromal cells. PDGF beta-receptor expressing cells in rheumatoid synovia were characterized by do
