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The isolation and characterization of six human cysteine proteinase inhibitors is reported. Their distribution in human biological fluids is also described and discussed with respect to physiological function. Studies on kininogen and cystatin C with respect to structure-function relationships and, as a result of the cystatin C studies, a general model for the mechanism of cysteine proteinase inhi
Aims Patients with a history of atrial fibrillation (AF) have previously been shown to have altered atrial conduction, as seen non-invasively using signal-averaged P-wave analysis. However, little is known about the P-wave morphology in patients in the early phases of AF with structurally normal hearts. Methods and results Thirty-six patients with lone AF were included before the age of 40 years (
The master thesis was done at QPharma to investigate a processing problem during production of tablets, where an excessive volume expansion during dry mixing of three ingredients occurred from time to time. A volume expansion (dilation) is needed for particles, within a powder, to become mixed with other particles. However, the extent of the dilation is dependent on intermolecular forces between p
Prostate-specific antigen (PSA) is a glycoprotein produced by the prostate gland. It occurs in several molecular forms in the blood and assays have been developed to measure free PSA and PSA in complex with alpha-1-antichymotrypsin (PSA-ACT). Higher proportions of free PSA (PSA-F/T) in blood are found in subjects with benign prostatic hyperplasia (BPH) as compared to cancer patients. Utilizing imm
BACKGROUND: Chemo- and radiotherapy (RT) is standard treatment for patients with high-grade glioma, but may cause side-effects on the patient's cognitive function.AIM: Use of diffusion tensor imaging (DTI) to investigate the longitudinal changes in normal-appearing brain tissue in glioblastoma patients undergoing modern arc-based RT with volumetric modulated arc therapy (VMAT) or helical tomothera
Background: Postural Orthostatic Tachycardia Syndrome (POTS) is a cardiovascular autonomic disorder characterized by orthostatic intolerance and high prevalence among young women. The etiology of POTS is uncertain, though autoimmunity and inflammation may play an important role. We aimed to identify novel inflammatory biomarkers associated with POTS. Methods and Results: In the Syncope Study of Un
An unbalanced chromosome number (aneuploidy) is present in most malignant tumours and has been attributed to mitotic mis-segregation of chromosomes. However, recent studies have shown a relatively high rate of chromosomal mis-segregation also in non-neoplastic human cells, while the frequency of aneuploid cells remains low throughout life in most normal tissues. This implies that newly formed aneu
BACKGROUND: Matrix metalloproteinases (MMPs) are thought to play a prominent role in atherogenesis and destabilization of plaque. Pericellularly localized membrane-type (MT)-MMPs activate secreted MMPs. We investigated the hypothesis that MT3-MMP is expressed in human atherosclerotic plaques and is regulated by locally produced inflammatory cytokines and oxidized low-density lipoprotein (Ox-LDL).
Objective. Transforming growth factor 13 (TGF)3) plays a key role in the onset and resolution of autoimmune diseases and chronic inflammation. The aim of this study was to delineate the precise function of TGF beta signaling in salivary gland inflammation. Methods. We impaired TGF beta signaling in mouse salivary glands by conditionally inactivating expression of TGF beta receptor type I (TGF beta
Idiopathic osteoporosis (IOP) in children is characterized by fragility fractures and/or low bone mineral density in otherwise healthy individuals. The aim of the present work was to measure bone mineralization density distribution (BMDD) based on quantitative backscattered electron imaging (qBEI) in children with suspected IOP. Entire cross-sectional areas of transiliac bone biopsy samples from c
Introduction: The purpose of this study was to develop a technique for automatic segmentation based on Fourier descriptors for separating smooth objects from the background in SPECT-images. The aim of the segmentation method was to be able to automatically outline kidneys in SPECT-images of patients undergoing radionuclide therapy with 177Lu-DOTATATE. The potential advantage of combining SPECT- an
Huvud.dvi Master’s Dissertation Structural Mechanics NIKLAS EDLIND MODELLING AND VISUALIZATION OF THE GEOMETRY OF FIBRE MATERIALS Detta är en tom sida! Copyright © 2003 by Structural Mechanics, LTH, Sweden. Printed by KFS I Lund AB, Lund, Sweden, June 2003. For information, address: Division of Structural Mechanics, LTH, Lund University, Box 118, SE-221 00 Lund, Sweden. Homepage: http://www.byggme
https://www.byggmek.lth.se/fileadmin/byggnadsmekanik/publications/tvsm5000/web5117.pdf - 2026-09-22
Residual stress can be introduced unintentionally into the workpiece with various magnitudes and distributions through all manufacturing processes. These stresses have a significant effect upon the performance of the final component. Understanding the residual stress imparted by machining is an essential aspect of understanding the machining process and overall part quality. Although many investig
In developing heterotopic bone in the rat, induced by allogeneic bone matrix, we immunohistochemically detected nerves containing substance P (SP), calcitonin gene-related peptide (CGRP), neuropeptide Y (NPY), vasoactive intestinal polypeptide (VIP) and tyrosine hydroxylase (TH). After 10 days they were dicernible amidst differentiating chondroblastoid cells in fibrous tissue around and within the
Tests were done measuring resistivity and time domain induced polarisation using standard multi-core cable spreads and a special layout with separate cable spreads for transmitting current and measuring potentials. For both types of cables spreads both normal and reciprocal measurements were done in order to estimate the measurement errors. The tests were done on a former landfill in Lund in Swede
Results of dedicated Monte Carlo simulations of beam-induced background (BIB) in the ATLAS experiment at the Large Hadron Collider (LHC) are presented and compared with data recorded in 2012. During normal physics operation this background arises mainly from scattering of the 4 TeV protons on residual gas in the beam pipe. Methods of reconstructing the BIB signals in the ATLAS detector, developed
The third cumulant for the aggregated multivariate claims is considered. A formula is presented for the general case when the aggregating variable is independent of the multivariate claims. Two important special cases are considered. In the first one, multivariate skewed normal claims are considered and aggregated by a Poisson variable. The second case is dealing with multivariate asymmetric gener
A basic intrusion (approximate1y 18 km2) occurs in southeastern Värmland about 20 km southeast of Kristinehamn. A few thin dikes of the basite penetrates the surrounding Filipstad granite. Adjacent to the basite the granite is magnetite- and garnetbearing and also secondary hypersthene and spinel are found in the granite. These observations indicate that the basite is postgranitic. The basite vari
Head: Karin Stenkula My research group is focused on experimental cell biology research within the diabetes and obesity field. The overall purpose of our research is to explore both normal adipose cell function and the cellular mechanisms causing impaired glucose- and lipid metabolism associated with insulin resistance and type 2 diabetes. At a single cell level, we have shown that the GLUT4 trans
https://www.ludc.lu.se/glucose-transport-and-protein-trafficking - 2026-09-29
