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A systematic review of chemotherapy trials in several tumour types was performed by The Swedish Council of Technology Assessment in Health Care (SBU). The procedures for the evaluation of the scientific literature are described separately (Acta Oncol 2001; 40: 155-65). This overview on chemotherapy for epithelial ovarian cancer is based on a total of 176 scientific reports. Five meta-analyses incl
This report by The Swedish Council on Technology Assessment in Health Care (SBU) reviews, classifies, and grades the scientific literature on cancer chemotherapy in some major tumour types, describes the practice of chemotherapy in Sweden, compares practice with scientific knowledge, and analyses the costs and cost-effectiveness of chemotherapy. The report is intended primarily for decision-makers
The proprioceptive, visual and vestibular sensory systems interact to maintain dynamic stability during movement. The relative importance and interplay between these sensory systems is still not fully understood. Increased knowledge about spatial perception and postural orientation would provide better understanding of balance disorders, and their rehabilitation. Displacement of the body in space
This paper seeks to discuss the nature of complex relationships among participants in organizational life, including ways in which paradox and ambiguity in their interactions impact upon organizational performance. Any relationship emerges and subsists through interaction between people. The nature of a relationship is the result of double description (Bateson, 2002). Each of the parties involved
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a progressive disabling condition, for which tobacco smoking, environmental pollution, inherited alpha-antitrypsin deficiency and their interactions are predisposing factors. We carried out a family study on COPD in order to address the role of heritable and environmental risk factors at a population level.METHODS: In a nationwide study o
In a previous 16-month seasonal study on living (stained) benthic foraminifera from two fjords on the Swedish west coast, it was reported that foraminifera proliferated in response to phytodetritus input; the strongest response came from the opportunistic species Stainforthia fusiformis. In this study, our objective was to find out if that phytodetritus input resulted in a change in the carbon iso
In this large-scale corpus study, we explore how direct speech is portrayed in English and Spanish Speech Framing Expressions (SFEs).While the whole SFE is taken into account in the semantic analysis, our specific focus is the finite verb of the SFE. The study has two aims. Firstly, we survey the use of verbs in SFEs and offer a comprehensive inventory of those verbs in English and Spanish as repr
Background: Persons with clinical onset of Alzheimer’s disease (AD) before 65 years of age are diagnosed with early-onset AD (EOAD). The prevalence of EOAD is low, but varies among studies from 6% to 16%. Most individuals with EOAD are still working, have an active social life, and might have children living at home. Therefore, the consequences of being diagnosed early with a disease that implies
Creativity is a principal force of cognitive and communicational genesis that causes alteration of established rules and concepts (Heine/Kuteva 2007) and transgression of cultural borders (Lotman 1990). Artistic activity is normally taken for granted as creative, despite the fact that much artistic intention, is not necessarily aspiring to make any radical change of the circumstances in which it i
In recent years there has been an increasing interest in museum studies in exhibitions on what is termed Difficult Matters (Silvén and Björklund 2006)—such as rape and mass murder—and how such exhibitions may evoke ethical change. This raises the question about the conditions on which such exhibitions can lead to an ethical change. By developing a conceptual framework this article contributes to m
We used remote sensing, geographical information systems, Google Earth™ images, and regional geology in order to (i) improve the mapping of linear structures and understand the chronology of different mafic dyke swarms in the Ahmeyim area that belongs to the Archean Tasiast-Tijirit Terrane of the Reguibat Shield, West African craton, NW Mauritania. The spatial and temporal distributions with the t
Endosymbiotic organelles of eukaryotic cells, the plastids, including chloroplasts and mitochondria, are highly integrated into cellular signalling networks. In both heterotrophic and autotrophic organisms, plastids and/or mitochondria require extensive organelle-to-nucleus communication in order to establish a coordinated expression of their own genomes with the nuclear genome, which encodes the
Anslagstavlan is a neglected but important part of Sweden’s modern audiovisual heritage. The purpose of this media historical and digital humanities project is to study the aesthetic, narrative and rhetorical development of audiovisual government information on Swedish television. While much research has been devoted to the Swedish public service model, wherein regulated independence from the gove
Full-field transmission X-ray microscopy (TXM) is a well established technique, available at various synchrotron beamlines around the world as well as by laboratory benchtop devices. One of the major TXM challenges, due to its nanometre-scale resolution, is the overall instrument stability during the acquisition of the series of tomographic projections. The ability to correct for vertical and hori
In order to study the characteristics of 3D gas-liquid interfaces, flow pattern transitions, and void fraction in mini tubes, virtual multi-vision experiments and numerical simulations are conducted in a 5.16 mm horizontal tube with air as the dispersed phase and water as the continuous phase. Air and water flow velocities range from 0.024 to 12.330 m/s and from 0.039 to 0.942 m/s, respectively. A
There is no alternative! Margaret Thatcher once proclaimed in order to defend neoliberalist reforms and – implicitly – the capitalist regime. But if one doesn’t agree with Thatcher’s definition of the situation and her (and her many followers’) subsequent analysis, what viable options does one really have? Is it possible to come up with an empirically grounded alternative to the dominant modes of
The crisis in fisheries, both in Sweden, Europe and globally, has for decades been a central topic for discussion among stakeholders with different perspectives. However, to regulate a problem and give the policy-making a proper target, there is a need for a common understanding of the problem. Inspired by Maarten Hajer, it is argued that discourses on environmental problems include story-lines an
OBJECTIVE: Recent in vivo results have shown prominent tissue sparing effect of radiotherapy with ultra-high dose rates (FLASH) compared to conventional dose rates (CONV). Oxygen depletion has been proposed as the underlying mechanism, but in vitro data to support this have been lacking. The aim of the current study was to compare FLASH to CONV irradiation under different oxygen concentrations in
The aim of this study was an in-depth investigation of the change process experienced by patients undergoing bariatric surgery. A prospective interview study was performed prior to as well as 1 and 2 years after surgery. Data analyses of the transcribed interviews were performed by means of the Grounded Theory method. A core category was identified: Wishing for deburdening through a sustainable co
