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Melanoma Genomics
Den aggressiva typen av hudcancer, även kallad melanom, är den typ av cancer som ökar mest i Sverige. Melanom uppkommer i melanocyter, en celltyp som producerar melanin och som i sin tur ger varje individ dess hudton. Melanom är den sjätte vanligaste tumörformen i Sverige med 3700 nya fall år 2014. Den starkaste prognostiska faktorn är tumörtjocklek. Det som saknas i melanomvården är en molekylär Recently the treatment landscape of metastatic melanoma has changed dramatically with introduction of targeted therapy and novel immune checkpoint blockade agents. However, acquired resistance to targeted therapy and relatively low response rates to immune therapy poses a major problem. Thus, increased knowledge in melanoma biology and identification of novel therapeutic strategies is a necessity
Transl onkogenomik
Translational Oncogenomics
Schmidtchen lab
Bacterial infections spanning from local wound infections, affecting patients with non-healing leg ulcers, postoperative wounds or burns, to severe infections and sepsis, are significant medical problems. Today's anti-infective treatments do not address the excessive activation of inflammatory pathways during infection and sepsis, and resistance problems are increasing. Hence, there is a huge unmBacterial infections spanning from local wound infections, affecting patients with non-healing leg ulcers, postoperative wounds or burns, to severe infections and sepsis, are significant medical problems. Today's anti-infective treatments do not address the excessive activation of inflammatory pathways during infection and sepsis, and resistance problems are increasing. Hence, there is a huge unm