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Herpes simplex virus type 1 (HSV-1) expresses a receptor that binds the Fc portion of IgG. This HSV-1 Fc gamma-binding protein is, like protein A of Staphylococcus aureus, known to bind human IgG1, IgG2 and IgG4 but not IgG3 subclasses. However, IgG3 with the allotype Gm(s+)(t+), prominent in the Oriental population, reacts with protein A. This prompted us to investigate the reactivity of Oriental
The binding site of immunoglobulin G (IgG) to herpes simplex virus (HSV) type 1-induced Fc receptor was investigated using human IgG Fc intermediate (Fc(i)) fragments, fragment D of staphylococcal protein A (SPA) and chemically modified human IgG. Human IgG Fc(i) fragment composed of one Cgamma2 and two Cgamma3 domains, bound strongly to HSV-1-infected cells. Fragment D, a monovalent subunit of SP
Immunoglobulin G (IgG) glycosylation modulates antibody activity and represents a major source of heterogeneity within antibody preparations. Depending on their glycosylation pattern, individual IgG glycovariants present in recombinant antibody preparations may trigger effects ranging from enhanced pro-inflammatory activity to increased anti-inflammatory activity. In contrast, reduction of IgG gly
To study the association between lifestyle and biological risk markers measured at one occasion, morbidity and mortality from cardiovascular disease (CVD) and cancer, and morbidity from diabetes approximately 26 years later.
Given global temperatures are expected to rise past the Paris Agreement’s 2°C limit, Liebherr Mining aims to develop products that progress their Zero Emission Mining strategy. This project therefore selected the major components required by a mobile ammonia-fuelled genset under certain operating conditions and assessed the proposed design against existing solutions. The project was built on find
The effectiveness of decision-making processes has been enhanced by integrating multi-criteria decision analysis (MCDA) and geographic information system (GIS) methods to solve more complex spatial problems that were not possible to solve using conventional GIS methods. A spatial decision support system (SDSS) supports various stakeholders in the decision-making process, by processing data using
