Filetype
Syftet med denna uppsats är att berika den befintliga teorin om verksamhetsstyrning inom offentlig sektor med fokusering på överensstämmelsen mellan mål och resurser i den offentliga hierarkin. Undersökningen är av en fallstudiekaraktär där forskningsprocessen bestått av ett antal personintervjuer. Dessutom har vi samlat in en del sekundär data som var nödvändig för att slutföra studien. Vi har va
Sub-barrier Coulomb excitation was performed on a mixed beam of 62Mn and 62Fe, following in-trap β− decay of 62Mn at REX-ISOLDE, CERN. The trapping and charge breeding times were varied in order to alter the composition of the beam, which was measured by means of an ionisation chamber at the zero-angle position of the Miniball array. A new transition was observed at 418 keV, which has been tentati
Essential hypertension is a multifactorial disorder and is the main risk factor for renal and cardiovascular complications. The research on the genetics of hypertension has been frustrated by the small predictive value of the discovered genetic variants. The HYPERGENES Project investigated associations between genetic variants and essential hypertension pursuing a 2-stage study by recruiting cases
Defining minimal standards for data collection is key to creating interoperative, searchable genomic and clinical databases. We highlight here the 1+Million Genomes Minimal Dataset for Cancer, encompassing 140 items in 8 domains to foster the collection of cancer data, inform transnational cooperation and advance precision cancer medicine.
TMA20 (MCT-1), TMA22 (DENR) and TMA64 (eIF2D) are eukaryotic translation factors involved in ribosome recycling and re-initiation. They operate with P-site bound tRNA in post-termination or (re-)initiation translation complexes, thus participating in the removal of 40S ribosomal subunit from mRNA stop codons after termination and controlling translation re-initiation on mRNAs with upstream open re
There is a need of problematizing taken for granted assumptions in the conceptualization of collaborative housing when attempting to link collaborative housing and social integration. What are the difficulties and opportunities that migrants and non-migrants face in accessing collaborative housing projects? Addressing such type of questions will help to capture exclusionary processes affecting old
Background: Emergency surgery for acute type A aortic dissection in patients with previous cardiac surgery is controversial. This study aimed to evaluate the association between previous cardiac surgery and outcomes after surgery for acute type A aortic dissection, to appreciate whether emergency surgery can be offered with acceptable risks. Methods: All patients operated on for acute type A aorti
This thesis is mainly concerned with the intersection between ideals and (maximal commutative) subrings of graded rings. The motivation for this investigation originates in the theory of C*-crossed product algebras associated to topological dynamical systems, where connections between intersection properties of ideals and maximal commutativity of certain subalgebras are well-known. In the last few
Popular Abstract in Swedish Cancer är den vanligaste dödsorsaken bland barn mellan 1–14 år i Sverige. Neuroblastom, som nästan uteslutande drabbar barn, är en aggressiv cancersjukdom som har sitt ursprung i det sympatiska (icke-viljestyrda) nervsystemet. I frisk vävnad råder strikt balans mellan celldelning och celldöd, medan cancerceller kännetecknas av en ohämmad celldelning och minskad celldödNeuroblastoma is a childhood tumor of the developing sympathetic nervous system (SNS) and is the most commonly diagnosed form of cancer in children before one year of age. Although survival curves have improved for these patients during the past decades, the conventional regimen of neuroblastoma treatment has clearly reached a plateau of efficiency with regard to increasing the survival rates of h
Behörighetsgivande högskolepedagogisk utbildning har nu blivit verklighet runt om i landet. Det finns från flera håll en stark förhoppning om att sådan utbildning ska bidra till att undervisningen utvecklas. Samtidigt kostar dessa kurser både pengar och tid, något som kanske går ut över andra utvecklingsinitiativ. Det är därför extra viktigt att ha ett utvecklingsperspektiv vid planering och genom
The aim of this thesis was to study the chemical communication involved in aggressive and reproductive behaviours in the European lobster (Homarus gammarus). Both male and female H. gammarus established and maintained dominance, but the sexes used different strategies for dominance maintenance. Male losers recognised individual fight opponents and avoided them but fought actively against unfamil
Popular Abstract in Swedish Cancer är en komplex och heterogen sjukdom där celler har börjat växa okontrollerat och denna sjukdom är idag ett stort hälsoproblem. På grund av diffusa symptom upptäcks cancern ofta i ett sent stadium. Otillräcklig kunskap om olika fenotyper hindrar utvecklingen av riktad behandling och patienter svarar därför väldigt olika på en given behandling. Denna avhandling ärCancer is a complex and heterogeneous disease where cells have started to grow uncontrolled and this disease remains a major health problem. Because of diffuse symptoms it often presents at a late stage. Insufficient understanding of the different phenotypes hinders the development of targeted therapeutics and consequently patients show a diverse range of responses to a given treatment. This thes
The discovery that paracetamol is metabolized to the potent TRPV1 activator N-(4-hydroxyphenyl)-5Z, 8Z, 11Z, 14Z-eicosatetraenamide (AM404) and that this metabolite contributes to paracetamol's antinociceptive effect in rodents via activation of TRPV1 in the central nervous system (CNS) has provided a potential strategy for developing novel analgesics. Here we validated this strategy by examining
Background: There is much interest in how the Amazon rainforest may respond to future rainfall reduction. However, there are relatively few ecosystem-scale studies to inform this debate. Aims: We described the carbon cycle in a 1 ha rainforest plot subjected to 8-10 consecutive years of ca. 50% through-fall reduction (TFR) and compare these results with those from a nearby, unmodified control plot
P2Y(2) receptors, which mediate contractile and mitogenic effects of extracellular nucleotides in vascular smooth muscle cells (VSMCs), are upregulated in the synthetic phenotype of VSMCs and in the neointima after balloon angioplasty, suggesting a role in the development of atherosclerosis. Because released cytokines in atherosclerotic lesions mediate multiple effects on gene transcription in VSM
Oxalate oxidase catalyses the degradation of oxalic acid to carbon dioxide and hydrogen peroxide and is of commercial importance for clinical analyses of oxalate in biological samples. Novel potential applications for oxalate oxidase include the prevention of the formation of calcium oxalate incrusts in pulp and paper manufacture and rapid determination of oxalic acid in process waters. The potent
