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Congenital muscular dystrophy with laminin α2 chain-deficiency (MDC1A) is one of the most severe forms of muscular disease and is characterized by severe muscle weakness and delayed motor milestones. The genetic basis of MDC1A is well-known, yet the secondary mechanisms ultimately leading to muscle degeneration and subsequent connective tissue infiltration are not fully understood. In order to obt
We use a nested-grid version of the GEOS-Chem chemistry transport model, constrained by isoprene emissions from the Model of Emissions of Gases and Aerosols from Nature (MEGAN), and the Lund-Potsdam-Jena General Ecosystem Simulator (LPJ-GUESS) bottom-up inventories, to evaluate the impact that surface isoprene emissions have on formaldehyde (HCHO) air-mass factors (AMFs) and vertical column densit
Popular Abstract in English Heme is a small red-colored molecule consisting of an iron atom bound to a chemical structure called porphyrin. Heme is essential for many organisms, including humans, because it is a cofactor in a variety of proteins that are needed to sustain metabolism. The probably most famous heme protein is hemoglobin which gives blood its red color. The heme cofactor in hemoglobiHeme proteins form a large and diverse group of proteins which are involved in a variety of biological functions. The heme prosthetic group enables them to carry out redox reactions, transport electrons, bind gaseous molecules, and function as sensors. Despite their importance only little is generally known about heme protein biogenesis. The Gram-positive bacterium Enterococcus faecalis is found i
Popular Abstract in Swedish Inledningen syftar till att ge en översikt över Swedenborgs levnadslopp och ge en viss orientering i litteraturen kring honom. Det visar sig att det saknas en grundlig idéhistorisk studie över hans tidiga mekanistiska naturfilosofi. Föreliggande bok kan sägas vara en kognitiv idéhistoria som har siktet inställt på hur han tänkte. I arbetet med Swedenborgs naturfilosofi The Swedish natural philosopher Emanuel Swedenborg (1688–1772) thought in his early scientific career that the world was like a gigantic machine, following the laws of mechanics and geometry. The work presented here is a study of his mechanistic worldview and metaphorical way of thinking up to the year 1734, examining most of his fields of interest, from geometry and metaphysics to technology and
Popular Abstract in Swedish Helicobacter pylori är en bakterie som orsakar såväl magkatarr, magsår som magsäckscancer. H. pylori producerar olika virulensfaktorer såsom enzymet ureas, ett cell vakuolbildande toxin (VacA), andra cytotoxiska proteiner (cagA eller pathogenicity island-associated proteins), flageller och adhesiner. För etablering av H. pylori infektion, måste dessa virulensfaktorer inHelicobacter pylori is a gastric pathogen which cause chronic type B gastritis and peptic ulcer disease. H. pylori produces virulence factors such as urease, vacuolating cytotoxin VacA, cag pathogenicity island-associated proteins, flagella and adhesins. These proteins interact with several host cell molecules such as sialylated cell surface glycoproteins, some of glycolipids and mucins. Glycosami
Oxalate oxidase catalyses the degradation of oxalic acid to carbon dioxide and hydrogen peroxide and is of commercial importance for clinical analyses of oxalate in biological samples. Novel potential applications for oxalate oxidase include the prevention of the formation of calcium oxalate incrusts in pulp and paper manufacture and rapid determination of oxalic acid in process waters. The potent
Electron-ion-ion coincidence measurements carried out at discrete resonances near the N 1s threshold in ammonia are reported. The measured coincidence spectra show clear alignment of the molecule upon resonant core-electron excitation. The coincidence data are analyzed to extract information about the molecule in the excited state by simulating the alignment and the dissociation processes. Dynamic
The electronic coupling strength within columns of discotic liquid crystals is investigated using core-level Coexisting well-ordered and disordered regions are identified in thin films of tetra-alkoxy-substituted phthalocyanines with the aid of near edge X-ray absorption fine structure and photoelectron spectroscopies. These different regions Lire used to derive a lower limit for the intermolecula
Introduction: Different sources of variations, such as electrogoniometer characteristics and procedures, may affect the accuracy and precision of movement measurements during gait. Objective: To quantify the variations and compare the effects produced by different sources of variation in electrogoniometric gait recordings: the sensors, procedures (trials) and the knee joint. Methods: Knee flexion/
The present study was undertaken to ascertain the frequency of cytogenetic polyclonality in various hematologic malignancies and to investigate whether morphologic subgroup, age, gender, or previous genotoxic exposure influences the incidence. Among 2,243 cytogenetically investigated hematologic malignancies, 10 acute myeloid leukemias (AML), 5 myelodysplastic syndromes (MDS), 2 acute lymphoblasti
Western flower thrips, Frankliniella occidentalis (Pergande) (Thysanoptera: Thripiclae), cause very large economic damage on a variety of field and greenhouse crops. In this study, plant resistance against thrips was introduced into transgenic potato plants through the expression of novel, custom-made, multiclomain protease inhibitors. Representative classes of inhibitors of cysteine and aspartic
BACKGROUND: Diagnostic methods for the study of allergic reactions to Anisakis simplex (A.s.) based on whole-body extracts of the larva are clearly insufficient. OBJECTIVES: To study the allergenicity of the proteins secreted by the parasite. Comparison with somatic antigens and determination of their clinical importance in allergic patients were also addressed. METHODS: An excretory/secretory (E/
Background Cardiovascular autonomic dysfunction is associated with increased incidence of cardiovascular diseases (CVD). This population-based study explored whether low FEV(1) or low vital capacity (VC) is associated with autonomic dysfunction, as measured by the spontaneous heart rate variability (HRV) and systolic BP variability (SBPV). Methods SBPV and HRV were recorded during 5 min of control
Neisseria meningitidis is a normal commensal of human mucous membranes that is no longer considered to be restricted to the nasopharynx. Due to the practice of oral sex, the mucous membranes of the cervix, urethra or anus have become a potential infection site for this bacterium. Inserting an intrauterine device (IUD), can alter the protective barrier of the endocervical mucosa, allowing for bacte
OBJECTIVE: There is great need of biomarkers for research and clinical purposes in COPD. This study explored the relationships between ten putative plasma biomarkers of COPD and physiological measures of reduced lung function. METHODS: FEV(1), FVC, residual volume/total lung capacity (RV/TLC) and CO diffusion capacity (D(L)CO) were assessed in 357 subjects from the Swedish Twin Registry. The l
Peter Pohl was born in Germany in 1940 but grew up in Stockholm, a setting reflected in many of his books. Pohl, a researcher at the Royal Technical University in Stockholm, made his fiction debut with the multi-prize-winning novel "Janne, min vän" (1985), and is internationally acclaimed for, among other things, the way in which his teenage novels highlight existential questions. The purpose of t
