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Non-germinal center (non-GC) phenotype, high level expression of the transcription factor forkhead box protein P1 (FOXP1) and anti-apoptotic protein Bcl-2 have been identified as unfavorable prognostic factors for diffuse large B-cell lymphoma (DLBCL) patients treated with chemotherapy. Our aim was to re-evaluate the prognostic impact of these biologic factors on the survival of the patients treat
Objective: Copy number variation is a common polymorphic phenomenon within the human genome. Although the majority of these events are non-deleterious they can also be highly pathogenic. Herein we characterize five families with parkinsonism that have been identified to harbor multiplication of the chromosomal 4q21 locus containing the a-synuclein gene (SNCA). Methods: A methodological approach us
For years, safety improvements have been made by evaluating incident reports and analyzing errors and violations. Current developments in safety science, however, challenge the idea that safety can meaning-fully be be seen as the absence of errors or other negatives. Instead, the question becomes whether a company is aware of positive ways in which people, at all level of the organisation, contrib
Animal venoms and toxins are a valuable source of bioactive peptides with pharmacologic relevance as potential drug leads. A large subset of biologically active peptides discovered up till now contain disulfide bridges that enhance stability and activity. To discover new members of this class of peptides, we developed a workflow screening specifically for those peptides that contain inter- and int
Purpose To ascertain the clinical implications of high hyperdiploid (HH; 49-65 chromosomes) and tri-/tetraploid (TT; >65 chromosomes) adult acute myeloid leukemia (AML), all such cases were retrieved from the Swedish AML Registry. Results Of the 3,654 cytogenetically informative cases diagnosed between January 1997 and May 2014, 68 (1.9%) were HH (n=50)/TT (n=18). Patients with HH/TT were older th
Introduction and hypothesis Urinary incontinence (UI) is common among the elderly, but the literature is sparse on the surgical treatment of UI among the elderly. This systematic review aims to assess the effectiveness of surgical interventions as treatment for urinary incontinence in the elderly population >= 65 years of age. Methods Randomized controlled trials (RCT) and prospective nonrandomize
A chemical proteomics approach using Ca2+/calmodulin-dependent protein kinase kinase (CaMKK) inhibitor–immobilized sepharose (TIM-063-Kinobeads) identified main targets such as CaMKKα/1 and β/2, and potential off-target kinases, including AP2-associated protein kinase 1 (AAK1), as TIM-063 interactants. Because TIM-063 interacted with the AAK1 catalytic domain and inhibited its enzymatic activity m
Introduction: Of newly diagnosed cases of haemophilia B, the proportion of sporadic cases is usually 50% of severe cases and 25% of moderate/mild cases. However, cases presumed to be sporadic due to family history may not always be sporadic. Few case reports have been published on mosaicism in haemophilia B. Aim: The present study aimed to trace the origin of the pathogenic variant in a well-defin
BACKGROUND: A blood-based test for the early detection of Parkinson's disease (PD) would be an important diagnostic tool and useful for patient selection when developing novel drugs or treatments for the disease.OBJECTIVE: Here, we aimed to identify potential biomarkers associated with PD.METHODS: We applied gene expression profiling to the study of peripheral blood from 75 healthy control subject
Vapor transport in porous media, often associated with liquid-vapor phase change, is an fundamental process in many emerging underground energy storage and extraction processes (i.e., seasonal solar thermal aquifer storage, geothermal extraction, extraterrestrial in-situ water extraction). By jointly using experimental imaging and numerical modeling at the micro-scale, we conduct mechanistic pore
Direct photolysis of the emerging contaminant 2-(thiocyanomethylthio) benzothiazole (TMCTB) was performed in aqueous solution at different concentrations with high-pressure mercury lamp (5.0, 8.0, 13.0, 16.0, 20.0, 23.0, 27.0, 35.0, 40.0, 45.0, and 50.0 mg L− 1) and with natural sunlight radiation (6.0, 30.0, and 60.0 mg L− 1). TCMTB underwent rapid degradation by direct photolysis with a high-pre
År 2009 reformerades det administrativa förfarandet för tillståndsprövningar av vindkraftverk, delvis för att en större vindkraftsutbyggnad skulle komma till stånd men också som nödvändig en åtgärd för att Sverige skulle uppfylla sina skyldigheter i 2009 års förnybarhetsdirektiv. Tidigare hade en ansökning om att få bygga vindkraft inneburit dubbla process- och tillståndsförfaranden enligt både PlIn 2009 the Swedish legislature regarding the administrative procedure applicable to wind energy projects was amended, in part to increase wind power construction but also as a measure to fulfil Sweden’s obligations stemming from the 2009 Renewables directive. As a result, the dual process- and permit procedure under both the Plan and Building Act and the Environmental Code was abolished. Instead,
The issue of food waste is a growing global problem having social, environmental and economic consequences. Over the recent years, this issue has received attention at International, national, regional and local levels. One such example is the case of Malmö which, in their Sustainable food policy has identified food waste as one of the key areas to reduce Greenhouse gas emission down to 40% of 200
Recombinant protein expression of Cas9 was performed at BioInvent International AB using prokaryotic and eukaryotic expression systems. For the eukaryotic expression, two types of mammalian cells were used namely HEK293 cells and CHO cells. The first expressions were performed using the pIRO-KL vector encoding the kappa leader secretory sequence. The kappa secretory sequence is responsible for tra
Under vårterminen 2021 genomfördes en avhandling på Volvo GTO. Volvo Lastvagnar är en av de största aktörerna inom fordonsindustrin och levererar lastbilar över hela världen. Företaget erbjuder lastbilar som kan anpassas och modiferas efter kundens önskemål. Att erbjuda lastbilar med hög anpassnings- och förändringsgrad innebär en hel del påfrestningar på systemet vilket kräver att CAD-ritningar,During the spring term of 2021 a thesis was carried out at Volvo Trucks GTO. Volvo Trucks is one of the largest and most successful actors in the automotive industry and delivers trucks all over the world. The company offers trucks that can be customized and adapted according to the customer wishes. Offering highly customizable trucks puts a lot of stresses on the system which requires that CAD-
Diffuse large B-cell lymphoma (DLBCL) is a highly heterogeneous malignancy which poses a challenge for treatment efficiency. To better stratify DLBCL patients and optimize treatment protocols, we analyzed the serum proteome using samples from a population-based cohort of DLBCL patients. Our objective was to find association between serum protein expression with clinical parameters such as overall
