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Det finns goda skäl till att engagera studenterna i kamratbedömning vid både formativ och summativ examination. Vi har under kursen Molekylär Cellbiologi för Ekosystemvetare vid LTH undersökt studenternas förmåga att bedöma muntliga projektredovisningar och jämfört den med lärarnas. Under kursen genomförde studenterna ett litteraturprojekt där en muntlig gruppredovisning med efterföljande kamratdi
Background: The clinical management of patients with coronary artery disease (CAD) often involves a complex assessment of the extent and severity of changes in left ventricular (LV) myocardial perfusion, function and viability. We aimed to explore the feasibility of integrative quantitative representation of LV perfusion, function and viability in adjacent polar plots. In order to assess the clini
Tadpoles from two types of ponds, temporary and permanent, were raised in a common garden experiment. There was no clear effect of pond type on development rate (time for metamorphosis). From each sibship, one group was raised under a constant water regime (deep tanks) and one was subject to simulated pond drying (shallow tanks). The tadpoles exhibited a plastic response to pond drying: they metam
Non-germinal center (non-GC) phenotype, high level expression of the transcription factor forkhead box protein P1 (FOXP1) and anti-apoptotic protein Bcl-2 have been identified as unfavorable prognostic factors for diffuse large B-cell lymphoma (DLBCL) patients treated with chemotherapy. Our aim was to re-evaluate the prognostic impact of these biologic factors on the survival of the patients treat
Objective: Copy number variation is a common polymorphic phenomenon within the human genome. Although the majority of these events are non-deleterious they can also be highly pathogenic. Herein we characterize five families with parkinsonism that have been identified to harbor multiplication of the chromosomal 4q21 locus containing the a-synuclein gene (SNCA). Methods: A methodological approach us
Denna artikel utgör den andra delen av två uppsatser som behandlar det patenträttsliga kravet att en patentsökt teknologi måste vara praktiskt användbar. Fokus ligger på gen- och proteinrelaterade uppfinningar. En tredje uppsats kommer att undersöka kravet på en tillräcklig beskrivning av dessa teknologier. Medan den första delen analyserade den US-amerikanska tolkningen av det särskilda ”utility”
Ibland kan man som lärare undra om man lever som man lär. En sak är i alla fall säker, vi lär som vi lever! Vårt nya stressade levnadssätt påverkar givetvis vårt sätt att lära. Under en kort tidsrymd har tre tekniska produkter påverkat lärandet mer än vad läroplaner eller vetenskapliga pedagogiska genombrott någonsin gjort - datorn, internet och mobiltelefonen. Bodil myntar att vi idag lever på
This thesis is based upon four original papers describing the characterisation of mantle cell lymphoma (MCL) tumours and cell lines in comparison with different populations of normal B cells. Gene expression profiling, which were used in the studies, has during recent years developed as an important tool in characterisation of different types of malignancies. In this thesis, the technique is used
Bonäsheden, Sweden's largest continuous dune field, situated in the county of Dalarna, central Sweden, has been investigated using LiDAR (light detection and ranging) remote sensing, ground penetrating radar as well as by field observations and luminescence dating. The use of LiDAR in conjunction with geographic information system (GIS) software proved to be efficient in mapping the inactive dune
Objective: Non-coding RNAs constitute a major fraction of the β-cell transcriptome. While the involvement of microRNAs is well established, the contribution of long non-coding RNAs (lncRNAs) in the regulation of β-cell functions and in diabetes development remains poorly understood. The aim of this study was to identify novel islet lncRNAs differently expressed in type 2 diabetes models and to inv
Short-chain fatty acids (SCFAs), e.g. acetic acid, propionic acid and butyric acid, generated through colonic fermentation of dietary fibers, have been shown to reach the systemic circulation at micromolar concentrations. Moreover, SCFAs have been conferred anti-obesity properties in both animal models and human subjects. Branched SCFAs (BSCFAs), e.g., isobutyric and isovaleric acid, are generated
Dog polymorphonuclear leukocyte cathepsin G was isolated from a granule extract using a two-step procedure including affinity chromatography on aTrasylol-Sepharose gel and ion-exchange chromatography on a CM 52 column. 22 of the first 24 N-terminal amino acids were determined and showed 83% and 71% identity to those of human and rat cathepsin G, respectively. Total amino-acid composition demonstra
Improving the lung function after experimental allergen challenge by blocking of mast cell (MC) mediators and the capability of MC mediators (including histamine, prostaglandin (PG) D2, and leukotriene (LT) C4) in induction of mucosal edema, bronchoconstriction, and mucus secretion provide evidence that MCs play a key role in pathophysiology of asthma. In asthma, the number of MCs increases in the
BACKGROUND: The importance of genetic factors in the etiology of Hodgkin lymphoma (HL) has been suggested by family and population studies. However, the spectrum of malignancies associated with common genetic etiology and the effects of gender and age on familial risk have not been established.METHODS: Diagnoses of lymphoproliferative malignancies were compared in 15,799 first-degree relatives of
