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Background Oral anticoagulation (OA) is a common treatment with a known risk of fatal or major bleeding, but also minor bleeding symptoms and menorrhagia can cause substantial discomfort and necessitate medical or surgical interventions. The extent of these side effects is however not previously reported. The objective of this study is to assess the frequency of minor bleeding symptoms and menorrh
PURPOSE: Isoform-specific tumor estrogen receptor β (ERβ) expression may hold prognostic information in breast cancer, especially among endocrine-treated breast cancer patients. The study's purpose was to evaluate ERβ isoform 1 (ERβ1) expression in relation to tumor characteristics, ESR2 genotypes, and prognosis in different treatment groups.EXPERIMENTAL DESIGN: A population-based prospective coho
BACKGROUND: Genome-wide association studies (GWAS) identified variants at 19p13.1 and ZNF365 (10q21.2) as risk factors for breast cancer among BRCA1 and BRCA2 mutation carriers, respectively. We explored associations with ovarian cancer and with breast cancer by tumor histopathology for these variants in mutation carriers from the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA). METHO
Popular Abstract in English The word “motion” usually brings to mind movement from point A to point B. In the world of chemistry, this kind of motion is typically referred to as translational motion. Its consequences are experienced by us every time we smell a scent in the air or watch a dye spread in water. The fragrance is nothing else than molecules that fly in the air. Colour is molecules swimThe work presented in this thesis is dedicated to theoretical development, experimental testing and application of polarization transfer solid-state nuclear magnetic resonance (PT ssNMR). PT ssNMR is an analytical tool which provides detailed information about molecular mobility in model or simple soft matter systems at the low water content regime, enabling the creation of phase diagrams. Soft ma
In a multicultural society, different cultures come in contact with each other which leads to many people need to relate to several cultures in their everyday lives. This study is aimed to highlight, analyze and discuss how young adult Malmö residents with a foreign background, reason about their identity creation in an environment where they are often reminded that they are different from the cro
PURPOSE The purpose of this study is to examine the effects of coworking space as it relates to meeting the common goals of collaboration, community, and creativity for its members. Through a case study of a coworking space, the study seeks answers to questions as: “How can coworking spaces enhance community, collaboration, and creativity to create a better experience for their members?” and “Are
Salutogenesis focuses on how come people recover or stay well. The answer was described to be a Sense of Coherence (SOC). SOC is a global orientation which contributes to how flexible coping strategies are chosen. The SOC concept was operationalized in The Sense of Coherence Scale (SOC-29). The questionnaire address to what extent life is perceived as comprehensible, manageable, and meaningful. T
Popular Abstract in Swedish Syftet med avhandlingsarbetet har varit att ge ökad kunskap om (1) psykosocial ohälsa i befolkningen, (2) prevalens och orsaker till psykosocial ohälsa bland patienter i primärvården, och (3) bland långtidssjukskrivna. Datainsamlingen inkluderar resultatet av en befolkningsenkät riktad till ett slumpmässigt urval av 13 000 personer (20-84 år), ett frågeformulär till samThe aim of the thesis is to contribute to knowledge of (1) psychosocial illness in the population, (2) the prevalence and nature of psychosocial illness encountered in primary health care, and (3) encountered among persons with long-term illness. The data collected include the results of a questionnaire given to a population-based sample of 13 000 persons (20-84 years), a questionnaire given to ge
Popular Abstract in Swedish Ett högt fiberintag från grönsaker, frukt och sädesslag som havre och korn minskar risken för hjärt- och kärlsjukdomar och typ 2 diabetes. Havre och korn har en hög halt av lösliga kostfiber, så kallade beta-glukaner (beta-glukaner) och studier har visat att beta-glukaner har intressanta hälsoeffekter. Ett dagligt intag av beta-glukaner från havre eller korn kan sänka kSince soluble fibre in the form of the cereal beta-glucans found in oats and barley has been shown to have a positive effect on lipid and glucose metabolism, people at risk of developing cardiovascular diseases or diabetes might benefit from that a variety of palatable food products containing beta-glucans being available to them. The aim of the papers presented in the thesis was to evaluate the m
Background: A potential dual role of folate in colorectal cancer (CRC) is currently subject to debate. We investigate the associations between plasma folate, several relevant folate-related polymorphisms, and CRC risk within the large European Prospective Investigation into Cancer and Nutrition cohort. Methods: In this nested case-control study, 1,367 incident CRC cases were matched to 2,325 contr
Titel: Validering av en handledsburen aktivitetsmätare och en självskattningskala för beräkning av VO2max. Bakgrund: Fysisk aktivitet och god aerob kapacitet är kopplat till god hälsa och lägre risk för livsstilsrelaterade sjukdomar. I dagsläget anses maximalt arbetsprov med ergospirometri och gasanalys för bestämning av VO2max (VO2max-test) vara det mest exakta sättet att mäta aerob kapacitet. Su
Hiphop is a culture that has grown among youth the last decades. Its based of four elements: breakdance, graffiti, djing and rap and each of these have their own way to express position, social status, power and identity. I want to know more what Swedish hip-hop stands for among rappers and producers. Goal: The goal is to get insight of what hip-hop means for the rappers and how they use hip-hop
Background: Chronic suppurative otitis media (CSOM) is an important cause of hearing loss in children and constitutes a serious health problem globally with a strong association to resource-limited living conditions. Topical antibiotics combined with aural toilet is the first-hand treatment for CSOM but antimicrobial resistance and limited availability to antibiotics are obstacles in some areas. T
Efficacy of human papillomavirus (HPV) vaccines promises to control HPV infections. However, HPV vaccination programs may lay bare an ecological niche for non-vaccine HPV types. We evaluated type-replacement by HPV type and vaccination strategy in a community-randomized trial executed in HPV vaccination naïve population. Thirty-three communities were randomized to gender-neutral vaccination with A
Objective: To review the Anorectal Malformation Network experience with perineal groove (PG) focusing on its clinical characteristics and management. Study design: Data on patients with PG managed at 10 participating Anorectal Malformation Network centers in 1999-2019 were collected retrospectively by questionnaire. Results: The cohort included 66 patients (65 females) of median age 1.4 months at
Background Tuberculosis is among the leading causes of death among infectious diseases. Regions with a high incidence of tuberculosis, such as sub-Saharan Africa, are disproportionately burdened by stillbirth and other pregnancy complications. Active tuberculosis increases the risk of pregnancy complications, but the association between latent tuberculosis infection (LTBI) and pregnancy outcomes i
Increased wealth and per capita energy use have transformed lives and shaped societies, but energy poverty remains a global challenge. Previous research has shown positive relationships among metrics of health and happiness and economic indices such as income and gross domestic product and between energy use and human development. To our knowledge, however, no comprehensive assessment has examined
Background: Patients experiencing high levels of pain after surgery remains a considerable clinical problem. Often, no consensus about the best analgesic treatment is present. The majority of clinical trials regarding postoperative pain, generally, target the average analgesic efficacy. In terms to step forward, a focus on the individual patients´ pain levels is needed and an identification of the
Background: Plasmodium falciparum malaria is an important cause of morbidity in northern Uganda. This study was undertaken to assess village-, household-, and individual-level risk factors of asymptomatic falciparum malaria in children in 12 villages in northern Uganda. Methods: Between 10/2011 and 02/2014, 1006 apparently healthy children under 16 years old were enrolled in 12 villages using a st
The aryl hydrocarbon receptor (AhR) is a master regulator of multiple pathways involved in breast cancer, and influences the estrogen receptor alpha (ER) and aromatase/CYP19A1. The purpose of this study was to elucidate the interplay between intratumoral levels of AhR and aromatase, patient characteristics (including AhR and CYP19A1 genotypes), clinicopathological features, and prognosis in breast
