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Helena Filipsson

Professor Kontaktinformation E-post: helena [dot] filipsson [at] mgeo [dot] lu [dot] se Telefon: +46 46 222 82 26 Mobil: +46 76 777 25 66Organisation Miljö- och geovetenskapliga institutionen (MGeo) Besöksadress: Geocentrum 2, Lund Rumsnummer: 386 Hämtställe: 16 WebbplatsHelena Filipssons profil i Lunds universitets forskningsportalAndra roller Professor Geologiska institutionen Medlem i Strategis

https://www.geologi.lu.se/helena-filipsson - 2026-05-30

The protonation status of compound II in myoglobin, studied by a combination of experimental data and quantum chemical calculations: Quantum refinement

Treatment of met-myoglobin (Fe-III) with H2O2 gives rise to ferryl myoglobin, which is closely related to compound II in peroxidases. Experimental studies have given conflicting results for this species. In particular, crystallographic and extended x-ray absorption fine-structure data have shown either a short (similar to170 pm) or a longer (similar to190 pm) Fe-O bond, indicating either a double

Utvärdering av olika farthinder på Malmös huvudgator

Varje år sker det tusentals olyckor i trafiken i Sverige till följd av det stora transportbehovet i samhället. Transportstyrelsen har ett mål, Nollvisionen, som innebär att ingen ska dödas eller skadas allvarligt i trafiken. För att nå målet är en åtgärd att hastigheten sänks där gång- och cykeltrafik behöver interagera med motorfordon. Det kan man göra i form av sidoförskjutningar, avsmalning av Every year, thousands of traffic accidents occur in Sweden as a result of the transportation need in society. The Swedish Transport Agency has a goal, Vision Zero, which means that no one should die or be severely injured in traffic. To reach the goal one measure is to reduce the speed where pedestrians and cyclists need to interact with motor vehicles. This can be done by chicanes, narrowing of t

Daily global solar radiation time series prediction using variational mode decomposition combined with multi-functional recurrent fuzzy neural network and quantile regression forests algorithm

Global solar radiation (GSR) prediction capability with a reliable model and high accuracy is crucial for comprehending hydrological and meteorological systems. It is vital for the production of renewable and clean energy. This research aims to evaluate the performance of combined variational mode decomposition (VMD) with a multi-functional recurrent fuzzy neural network (MFRFNN) and quantile regr

Response of six European forest sites to decided and proposed air pollutant emission reductions

Two acid deposition scenarios were simulated for six European forest sites situated in Germany, Denmark, Russia, Switzerland, Spain and Ireland. Three models were used in combination; the RAINS (Regional Acidification INformations and Simulation) model, the SAFE (Simulating Acidification in Forest Ecosystems) model and the MakeDep model. The scenarios used were based on results from international

Samverkan och kommunikation i ett byggprojekt

Communication is a keyword to success in a construction project and whit modern-days situation with the reduced building time and a lot of stress involved is it very important that correct information reaches out to the right persons on the right time. Many different partners are involved in the building project and each one of them works towards their own goals without thinking of the integrity.

Isotherms for adsorption of cellobiohydrolase I and II from Trichoderma reesei on microcrystalline cellulose

Adsorption to microcrystalline cellulose (Avicel) of pure cellobiohydrolase I and II (CBH I and CBH II) from Trichoderma reesei has been studied. Adsorption isotherms of the enzymes were measured at 4 degrees C using CBH I and CBH II alone and in reconstituted equimolar mixtures. Several models (Langmuir, Freundlich, Temkin, Jovanovic) were tested to describe the experimental adsorption isotherms.

Den som dokumenterar en grop åt andra

An archaeological excavation made within contract archaeology almost invariably means that the site is destroyed. This means that the documentation, which can be seen as the site’s remaining archive, is extremely important. In this master’s thesis the written digital documentation from eight excavations made within Swedish contract archaeology between 2000 and 2013 is examined using the technique

Enhancing the Activity of a Dietzia sp. D5 Baeyer-Villiger Monooxygenase towards Cyclohexanone by Saturation Mutagenesis

A recombinant Baeyer-Villiger monooxygenase, BVMO4 from Dietzia sp. D5 has been previously reported. The enzyme exhibited good thermostability and was active with a wide range of cyclic ketone substrates but catalysed poorly the conversion of cyclohexanone to caprolactone. The present work focuses on protein engineering of BVMO4 to improve the conversion of cyclohexanone. Thus, a structural model

A Genetic Algorithm for Optimizing Mobile Stroke Unit Deployment

A mobile stroke unit (MSU) is an advanced ambulance equipped with specialized technology and trained healthcare personnel to provide on-site diagnosis and treatment for stroke patients. Providing efficient access to healthcare (in a viable way) requires optimizing the placement of MSUs. In this study, we propose a time-efficient method based on a genetic algorithm (GA) to find the most suitable am

Många allvarliga brott mot regler när läkemedel marknadsförs

Läkemedelsindustrin är en viktig källa till läkemedelsinformation. Industrins marknadsföring kan dock leda till användning av icke-ändamålsenliga eller onödigt dyra läkemedel [1]. En ny studie, publicerad i PLoS Medicine, har analyserat marknadsföring i Sverige och Storbritannien 2004–2012 samt de egenåtgärdssystem som industrin i de båda länderna inrättat för tillsynen av marknadsföringen [2]. Sl

THE HYPOXIC HEMATOPOIETIC STEM CELL NICHE Consequences of Hypoxia-induced Transcription on Stem Cell Fate

Popular Abstract in Swedish Stamceller är unika celler som har möjlighet att både förnya sig själva och ge upphov till en mängd mogna celler. Den ultimata stamcellen är det befruktade ägget, som är den cell som efter omfattande celldelning kommer att ge upphov till alla vävnader och celler i den färdigutvecklade kroppen. Dessa celler kallas därför pluripotenta. Även i den färdigutvecklade kroppen Hematopoiesis is the process of blood formation that originates with the hematopoietic stem cell (HSC), a cell type that is responsible for the life-long supply of mature blood cells. HSCs are defined by their ability to self-renew as well as giving rise to differentiated cells of all blood lineages. Because of these features, HSCs are also the basis for bone marrow transplantation regimens for tr

BNCT in vivo dosimetry A feasibility study using an HPGe detector for prompt gamma spectroscopy

Increased accuracy in patient dosimetry in BNCT is needed. This need for more accurate individual patient dose estimations initiated this project at the Swedish BNCT facility at Studsvik. One possible way to achieve this is to use an HPGe detector. This project involves the complete construction and testing of such a system in a treatment representative environment.The system builds on an ORTEC GM

The Epidemiology of Childhood Celiac Disease: A Social Epidemiological Perspective on Perinatal Factors

Popular Abstract in Swedish Under livets gång utsätts vi för en mängd exponeringar som påverkar vår hälsa. I denna avhandling har vi försökt förstå hur olika exponeringar påverkar risken för celiaki (glutenintolerans) hos barn. Vi har utnyttjat information i nationella register och använt epidemiologiska metoder. Med ett socialepidemiologiskt tankesätt lyfter vi blicken från individen till att äveCeliac disease is a chronic gastrointestinal disease affecting approximately 1% of the population. It is precipitated in genetically predisposed individuals by ingestion of food containing gluten or similar proteins that are present in wheat, rye and barley. The disease might present with symtoms such as malnutrition, diarrhea or abdominal bloating, but a large proportion of those afflicted by the

Proton Magnetic Resonance Spectroscopy in Brain Tumors - Clinical Applications

Popular Abstract in Swedish Hjärntumörer är en relativt vanlig sjukdom som förekommer hos både barn och vuxna. Utredning, prognosticering och uppföljning av patienter som har drabbats av sjukdomen sker genom klinisk undersökning och med hjälp av bildgivande tekniker som datortomografi (DT) och magnetisk resonans (MR) tomografi, i dagligt tal magnetkamera. I vissa fall kan det vara svårt att skiljaAims: · to present a test phantom and test method for evaluation of proton magnetic resonance spectroscopy (1H-MRS) single volume localization techniques regarding signal contamination; · to describe the introduction of 1H-MRS in the daily routine of a standard MR-unit; · to evaluate the possibilities offered by 1H-MRS to improve preoperative diagnostic accuracy in patients scheduled for stereotac

Radiotherapy Gel Dosimetry: Development and Application of Normoxic Polymer Gels

In many radiotherapy applications, true three-dimensional dosimetry with good spatial resolution that can be achieved in a single measurement would be of great value. Polymer gel dosimetry fulfils many of the demands on such a system. In this study, methods to facilitate the implementation of gel dosimetry have been investigated. A new type of polymer gel, for which the response to absorbed dose i

Radioimmunoimaging and Radioimmunotherapy of Prostate Cancer Preclinical evaluation of kallikrein related peptidase 2 targeting

Prostate cancer is one of the major causes of cancer related deaths in men in Europe and the United States. In this doctoral thesis, radioimmunoimaging and -therapy of prostate cancer was investigated pre-clinically by targeting the human kallikrein-related peptidase 2 (hK2) with radiolabelled monoclonal antibodies. hK2 is an antigen that is over-expressed in prostatic neoplasms and is closely rel

Modelling parkinsonian akinesia and dyskinesia in dopamine depleted rodents

Popular Abstract in Swedish Parkinsons sjukdom är en av de vanligaste neurologiska sjukdomarna i västvärlden. Vad som orsakar sjukdomen är fortfarande okänt men det betyder sannolikt att det är många faktorer som samverkar för att leda fram till sjukdomen. De mest framträdande symptomen i Parkinsons sjukdom är stelhet, oförmåga att initiera rörelser (s.k. akinesi), balanssvårigheter och tremor (daAnimal models of Parkinson’s disease and L-DOPA-induced dyskinesia are essential to explore pathophysiological hypotheses and to test new treatment options. There are many different animal models of Parkinson's disease, which differ greatly with respect to species, mechanisms of nigral cell death, and extent of dopamine-dependent motor deficits. My work has been performed in rats and mice with uni

Reglerna om ansvarsfrihet vid rättelse av oriktig uppgift på eget initiativ

In cases where inaccurate information has been sent to tax authorities, the responsible person is risking surcharge or in worse cases making herself guilty of tax offence. A basic rule implies that a surcharge means an additional 40 % to the normal taxes and when it comes to cases of tax offence, the ordinary penalties of criminal law, fines and prison, are practiced. The highest prison sentence f

Vad kan försäkras? - En utredning av det försäkringsrättsliga begreppet lagligt intresse, med fokus på administrativa sanktionsavgifter

Av försäkringsavtalslagen, FAL, 6 kap. 1 § framgår att bara lagliga intressen kan försäkras. Den här uppsatsen syftar till att genom en rättsdogmatisk metod utreda vilken innebörd begreppet lagligt intresse har. Fokus ligger på att undersöka hur administrativa sanktionsavgifter enligt EU:s nya dataskyddsförordning bör behandlas i svensk försäkringsrätt och om det är möjligt att försäkra sig mot riAccording to the Swedish Insurance Contracts Act (FAL) 6 chapter 1 §, only legal interests can be insured. By using a legal dogmatic method, this essay seeks to examine the significance of the term legal interest. This paper is especially focused on investigating how administrative fines, pursuant to the new EU General Data Protection Regulation (GDPR), should be treated in Swedish insurance law,