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Trisomy 8 (+8) is a common cytogenetic aberration in acute myeloid leukemia (AML); however, the impact of +8 in pediatric AML is largely unknown. We retrospectively investigated 609 patients from the NOPHO-AML database to determine the clinical and cytogenetic characteristics of +8 in pediatric AML and to investigate its prognostic impact. Complete cytogenetic data were available in 596 patients (
We sought to identify novel pharmacogenetic markers associated with cardiovascular outcomes in patients with hypertension on antihypertensive therapy. We genotyped a 1:4 case:control cohort (n=1345) on the Illumina HumanCVD Beadchip from the INternational VErapamil SR-Trandolapril STudy (INVEST), where participants were randomized to a -blocker strategy or a calcium channel blocker strategy. Genom
The neurodegenerative Huntington's disease (HD) is caused by a polyglutamine (polyQ) amplification in the huntingtin protein (HTT). Currently there is no effective therapy available for HD; however, several efforts are directed to develop and optimize HTT-lowering methods to improve HD phenotypes. To validate these approaches, there is an immediate need for reliable, sensitive, and easily accessib
Hur rättfärdig är icke lagen: den förbjuder såväl den rike som den fattige att sova under broarna och tigga bröd. Detta kända citat av författaren Anatole France illustrerar inledningsvis en övergripande del av mitt syfte med denna uppsats. Lagen ska i sin utformning som utgångspunkt vara generell, förutsägbar och lika för alla – ändock drabbar den oundvikligen olika (grupper) av befolkningen påThe law, in its majestic equality, forbids the rich as well as the poor to sleep under bridges, to beg in the streets, and to steal bread. This famous quotation by the author Anatole France will serve as an introduction to a major part of the scope of this essay. The law shall in its form be general, foreseeable and applied equably in regard to all citizens – despite this, the law strikes differ
In last decade, the lighting industry significantly changed with the development of light emitting diodes (LEDs) and their corresponding penetration of the market. The new technology increases energy efficiency and longevity compared to other types of lamps. As a result, LEDs can improve the sustainability performance of cities and towns, contributing to the mitigation of climate change and cuttin
Background: Patients with cyanotic congenital heart disease (CCHD) may have a low burden of atherosclerosis. Endothelial dysfunction is an early stage of atherosclerosis and endothelial function is previously studied in smaller CCHD groups with different techniques and variable results. We aimed to examine endothelial function and carotid atherosclerosis in a larger group of CCHD patients. Methods
INTRODUCTION: Since sleep disturbance is a modifiable risk factor for Alzheimer's disease (AD), we tested associations between sleep and AD pathology in cognitively unimpaired (CU) persons. METHODS: We included 223 participants from the PREVENT-AD cohort with self-reported measures of sleep, objective actigraphy measures of sleep, and positron emission tomography (PET) scans for AD pathology quant
The shore protection regulation has a long tradition in Sweden, with increas-ing emphasis placed over time on the need to protect shorelines from devel-opment. In July 2025, legislative amendments entered into force, and an ongoing inquiry is examining the possibility of more flexible legislation. This thesis employs the legal dogmatic method to examine the shore protec-tion regulation with the ai
År 2008 brakade den finansiella marknaden samman och följdes av en recession världen över som vi till viss del fortfarande brottas med. OTC-derivat, ett skräddarsytt bilateralt finansiellt instrument, har i finanskrisens efterdyningar beskyllts vara en av bovarna i dramat. Särskilt tros OTC-derivaten ha bidragit till en icke-transparens på marknaden som gjorde det omöjligt att både förutse och förIn 2008 the financial market collapsed and what followed was a worldwide recession which the market has yet to fully recover from. OTC-derivatives, which are tailor-made bilateral financial instruments, have in the aftermath of the collapse been accused of being one of the culprits. More specifically, OTC-derivatives are believed to have contributed to the opaque financial market that made it impo
The adoption of a so-called consent-based rape law has been heavily debated for over two decades. On July 1st, 2018 a rape clause based on voluntarism was introduced. As a result, the rape regulation was extended in such a way that it no longer requires force, or exploitation of a particular vulnerable situa-tion, for criminal liability to occur. The purpose of the new rape regulation is to protec
Idag återfinns sexistiska kommentarer på sociala medieplattform, trots att företagen bakom har regler för vad som får publiceras. Sexism är ett strukturellt problem som kan påverka kvinnor negativt, både fysiskt och psykiskt och kan leda till självcensur. Ge- nom en kvalitativ textanalys syftar denna uppsats att testa om tre principer kan användas för att analysera om sexistiska kommentarer från FToday, sexist comments can be found on social media platforms, despite social media companies having rules on what is allowed to be published. Sexism is a structural prob- lem which can negatively affect women, both physically and mentally, and could lead to self-censorship. Through a qualitative text analysis, this essay aims to investigate whether sexist comments from Facebook and Instagram are
On July 1 this year, a new crime for involving a minor in crime will be introduced in Chapter 16, Section 5 a of the Swedish Penal Code. In the government bill, the purpose of the new criminalization is described as protecting society from young people being drawn into criminal networks. For a penal provision to be considered justified, there are several criminalization principles to which it mus
Until July 1, 2018, Swedish legislation lacked a general remedy for delays in the authorities’ handling of cases. With the introduction of section 12 of the Public Administration Act the remedy, often referred to as the delay action, came to change the Swedish Migration Agency’s routine handling of citizenship applications. Authorities would henceforth not be able to act passively in the handling
Häktning är ett straffprocessuellt tvångsmedel som kan användas vid utredning av misstänkt brottslighet. Häktning kan under vissa förutsättningar kombineras med restriktioner, med följd att den häktade isoleras från omvärlden. Det svenska häktningsinstitutet har sedan tidigt 90-tal återkommande erhållit internationell kritik. Kritiken har bland annat avsett att det saknas tidsgränser för hur längeRemand is a coercive measure which may be used while investigating a suspected crime. Remand may, under certain conditions, be combined with restrictions, resulting in the detainee being isolated from the outside world. The Swedish remand institute has received international criticism since the early 1990s. The criticism has, among other things, been related to the lack of time limits for how long
Mjukvaror och produktansvarslagen - en komparativ studie är en komparativ studie som belyser den svenska och danska produktansvarslagstiftningens tillämpligheten på mjukvaror och vad för problematik som uppstår om gällande lagstiftning inte omfattar mjukvaror. Tillämpligheten har diskuterats utifrån analyser av förarbeten och hur frågan har diskuterats i litteraturen. Slutligen förs ett resonemangMjukvaror och produktansvarslagen - en komparativ studie is a comparative study that illustrate the applicability of the Danish and Swedish Product Liability Act and what problems arise if the current legislation does not include software. The applicability has been discussed based on analyzes of preliminary work and how the issue has been discussed in the literature. Lastly, there is a discussion
