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Brevmall KURSPLAN Dnr U 2017/ 69 1(2) Fastställd av FUN 2017-04-05, gäller från 2017-05-01 Generiska kunskaper och färdigheter, MEPO003 Generic knowledge and skills 12 högskolepoäng Nivå F Allmänna uppgifter Kursen ingår som ett obligatoriskt moment i utbildning på forskarnivå och fokuserar på de generiska kunskaper och färdigheter som är en del av forskarutbildningen. Kursen är individuell, löper
Cardiac fibrosis, associated with a decreased extent of microvasculature and with disruption of normal myocardial structures, results from excessive deposition of extracellular matrix, which is mediated by the recruitment of fibroblasts. The source of these fibroblasts is unclear and specific anti-fibrotic therapies are not currently available. Here we show that cardiac fibrosis is associated with
Dysfunctional microRNA (miRNA) networks contribute to inappropriate responses following pathological stress and are the underlying cause of several disease conditions. In pancreatic beta cells, miRNAs have been largely unstudied and little is known about how specific miRNAs regulate glucose-stimulated insulin secretion (GSIS) or impact the adaptation of beta cell function to metabolic stress. In t
Ternary semiconductor nanowire arrays enable scalable fabrication of nano-optoelectronic devices with tunable bandgap. However, the lack of insight into the effects of the incorporation of Vy element results in lack of control on the growth of ternary III-V1-yVy nanowires and hinders the development of high-performance nanowire devices based on such ternaries. Here, we report on the origins of Sb-
OBJECTIVE-We report here genotyping data and type 1 diabetes association analyses for HLA class I loci (A, B, and C) on 1,753 multiplex pedigrees from the Type 1 Diabetes Genetics Consortium (T1DGC), a large international collaborative study. RESEARCH DESIGN AND METHODS-Complete eight-locus HLA genotyping data were generated. Expected patient class I (HLA-A, -B, and -C) allele frequencies were cal
The World Health Organization (WHO) classification of myeloid leukaemia was revised in 2008. It incorporates newly recognized entities and emphasizes the pivotal role of cytogenetic abnormalities. The aim of this study was to evaluate the usability of the WHO classification when applied to a large population-based paediatric acute myeloid leukaemia (AML) cohort. We included children diagnosed with
Popular Abstract in Danish Omkring halvdelen af den globale kulstof mængde som findes i jorden, er lagret i de arktiske jorde. Arktiske jorde har været anset for at være vigtige kulstof reservoirs de sidste 10.000 år, hvor der bliver optaget mere kulstof end der frigives. Dette skyldes blandt andet den langsomme omsætning af organiske materiale på grund af de kolde forhold, men også de store mængdArctic ecosystems hold massive amounts of the global carbon in their soils and are of great importance for the global terrestrial exchange of greenhouse gases to the atmosphere. The arctic region has in general been acting as a C sink for the past 10000 years, however with climate change the C balance in some areas is shifting towards becoming a C source. Herbivory are an important part of many ec
Promoter methylation is a common phenomenon in tumours, including haematological malignancies. In the present study, we investigated 36 cases of high hyperdiploid (> 50 chromosomes) acute lymphoblastic leukaemia (ALL) with methylation-specific multiplex ligase-dependent probe amplification to determine the extent of aberrant methylation in this subgroup. The analysis, which comprised the promoters
Aquaglyceroporins are channels that facilitate the flux of glycerol and water across lipid bilayers. Although structural information is available for several aquaglyceroporins, the details of how water and glycerol selectivity are maintained and how protons are excluded remain elusive. An approach to obtaining data on the hydrogen atom positions is to apply neutron macromolecular crystallography.
Chronic obstructive pulmonary disease (COPD) is a leading cause of death world-wide. Recently, we showed that COPD is associated with gene polymorphisms in SUMF1, a master regulator of sulfatases. Sulfatases are involved in extracellular matrix remodeling and activated by SUMF1, but their role in the lung is poorly described. We aimed to examine how sulfatases are affected in the airways of patien
Obesity is a major threat to global health and metabolically associated with glycerol homeostasis. Here we demonstrate that in human adipocytes, the decreased pH observed during lipolysis (fat burning) correlates with increased glycerol release and stimulation of aquaglyceroporin AQP10. The crystal structure of human AQP10 determined at 2.3 Å resolution unveils the molecular basis for pH modulatio
Background: The Bethesda system for cytopathology (TBSRTC) is a 6-tier diagnostic framework developed to standardize thyroid cytopathology reporting. The aim of this study was to determine the risk of malignancy (ROM) for each Bethesda category. Methods: Thyroidectomy-related data from 314 facilities in 22 countries were entered into the following outcome registries: CESQIP (North America), Eurocr
LL_KSMC21_VT20_rev_191113 Litteraturlista för Health management: Hälsosektorns spridning (KSMC21), 15 hp. Litteraturlistan är fastställd av styrelsen för Institutionen för service management och tjänstevetenskap 2017- 11-21, reviderad 2019-11-13. Litteraturlistan börjar gälla 2020-01-01. Andersson, Ingemar & Ejlertsson, Göran. (2009). Folkhälsa som tvärvetenskap – möten mellan ämnen. Lund: Student
https://www.ses.lu.se/sites/ses.lu.se/files/ll_ksmc21_vt20_rev_191113.pdf - 2025-11-17
Glacial-interglacial variations in CO 2 and methane in polar ice cores have been attributed, in part, to changes in global wetland extent, but the wetland distribution before the Last Glacial Maximum (LGM, 21 ka to 18 ka) remains virtually unknown. We present a study of global peatland extent and carbon (C) stocks through the last glacial cycle (130 ka to present) using a newly compiled database
Denna uppsats avhandlar IFO insats - öppenvård vuxna missbruk, som är en organisation tillhörande Arbetsmarknads- och socialförvaltningen Malmö stad. IFO står för Individ och Familjeomsorg, och är en insats klienter kan bli beviljade under missbruksproblematik. Vi kommer i denna uppsats beteckna denna organisation med “IFO insats”. Under 2019 påbörjades en diskussion kring öppenvården i Malmö. En
The criminalization of letting children witness domestic violence entered into force in Swedish law on 1 July 2021 and is thus a relatively new offence. It is found in Section 4. Chapter 3. in the Swedish Criminal Code and means that it is now a criminal offence to expose a child to witnessing domestic violence. The purpose of the penalty provision is to notice and give legislative protection to c
On July 1st., 2013 the Swedish rape legislation was changed with the introduction of the prerequisite particulary exposed situation that replaced the previous prerequisite helpless state. The motive for this change was, among other things, that the courts had been too restrictive in their adjudication of the prerequisite helpless state. Furthermore, it seemed impossible to investigate and prosecut
