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Purpose Pretreatment prostate-specific antigen (PSA) dynamics (PSA velocity and PSA doubling time) are widely advocated as useful prognostic markers in prostate cancer. We aimed to assess the published evidence for the clinical utility of PSA dynamics in this population. Methods We conducted a systematic review of studies published before March 2007 in which a PSA dynamic (velocity or doubling tim
Introduction and objectives Children with attention deficit hyperactivity disorder (ADHD) have an increased risk of sleep problems. Weighted blankets are one possible non-pharmacological intervention for these problems in this group of children. However, the effectiveness of weighted blankets is insufficiently investigated. This study aims to investigate the effectiveness of weighted blankets in t
Succinic acid production from the monosaccharides xylose, arabinose, glucose, mannose and galactose was studied using the bacterium Actinobacillus succinogenes. In Duran bottle cultures, containing 10 g/L of each of sugar, succinic acid was produced from all sugars except for galactose. The highest succinate yield, 0.56 g/g, was obtained with glucose, whereas the succinate yield was 0.42, 0.38 and
Brake pads on wheel-mounted disc brakes are often used in rail transport due to their good thermal properties and robustness. During braking, both the disc and the pads are worn. This wear process generates particles that may become airborne and thus affect human health. The long term purpose of 'Airborne particles in Rail transport' project is to gain knowledge on the wear mechanisms in order to
Introduction: Hypothyroidism is a common disorder, appearing mainly in women although less frequently found in women with polycystic ovary syndrome (PCOS). The objective was to test the hypothesis that hyperandrogenism might protect against hypothyroidism. Material and methods: The data from three prospective follow-up studies (up to 21 years) and one register study were compared: women with PCOS
Ultrasonic Consolidation (UC) is a manufacturing technique based on the ultrasonic metal welding of a sequence of metal foils which are bonded to one another in a layer by layer manner. It combines the ability of additive and subtractive manufacturing techniques to create complex three-dimensional shapes. Due to moderate applied pressures and the relatively low temperatures experienced by a sample
Hypertension is a major risk factor for stroke, which is one of the leading global causes of death. In the search for new and effective therapeutic targets in stroke research, we need to understand the influence of hypertension in the vasculature following stroke. We used Affymetrix whole-transcriptome expression profiling as a tool to address gene expression differences between the occluded and n
Purpose: To evaluate the short-term feasibility, efficacy, and safety of a modular bifurcated stent-graft with an internal iliac artery (IIA) side branch for endovascular repair of aortoiliac aneurysms. Methods: Between 2002 and 2005, 10 male patients (median age 75 years, range 59–83) were treated with a bifurcated stent-graft that included a unilateral side branch for the IIA. The median diamet
When deciding upon the usage of direct deliveries as opposed to central inventories, efficiency and strategic effects need to be considered. Operations management literature on efficiency effects is not hard to find but literature describing what other factors can affect the decision is more scarce. Even less literature can be found on the theme of deciding between direct or indirect physical flow
The purpose of the existing methods for limiting the researcher’s bias is to see to that we have an objective and rational research. But what if there exist collective biases, and that the current process of falsification through peer to peer review only hinder individual ones. And this can happen because there is a shared fundamental belief system (FT) within the field, acquired through mutual ed
Sammanfattning Den markant ökade användningen av krypterade kommunikationstjänster inom kriminella nätverk i syfte att planera och dölja kriminella förehavanden gäckade länge brottsbekämpande myndigheter både i Sverige och på kontinenten. Av naturliga skäl var det därför en stor framgång när franska myndigheter i nära samarbete med Eurojust och Europol lyckades knäcka den krypterade kommunikationsAbstract The distinct increase regarding use of encrypted communication within organised criminal networks in order to plan and conceal criminal activity eluded law enforcement authorities in Sweden as well as on the European continent for a long time. Therefore, for obvious reasons, it was considered a huge success when French authorities in close cooperation with Eurojust and Europol were able t
BorgWarner continuously improves the performance of their friction system, and by that also need more sophisticated measurement methods. The friction system is developed to minimize noises caused by vibrations to improve customer satisfaction. However, studies from BorgWarner show that in some specific drivetrain operations, vibrations can be induced from the friction discs (lamellas) caused by st
In the field of development economics corruption is considered a major obstacle to economic development. When opportunities to abuse power for self-interest are widespread, inequalities may become reinforced and democratic and economic development will be undermined. Empirical studies have found a negative relationship between gender and corruption implying that increased female participation lowe
Den svenska staten bedriver affärsverksamhet via ett femtiotal företag av vilka staten äger minst 50% av företaget i 43 av fallen. År 2007 antog den svenska regeringen en rad nya riktlinjer gällande hållbarhetsrapportering för dessa företag. Dessa nya riktlinjer skulle tas i bruk från och med räkenskapsåret 2008. Hållbarhetsrapporteringen, dvs. den icke finansiella rapporteringen av dessa svenska In 2007 the Swedish government adopted a set of guidelines mandating all Swedish state-owned companies to conduct a non financial report i.e. a sustainability report that is to be independently verified. The sustainability report is to be in line with the internationally recognized Global Reporting Initiative framework (G3), a framework of guidelines for how to conduct sustainability reports. The
The logic scaling following Moores law has reached a level where System on Chips (SoCs) commonly contains millions of standard cells. The sheer amount implies that even small optimizations on a standard cell can have a significant effect on the SoC performance. To ensure the performance of standard cells, many of these are hand-drawn. This is a tedious task that needs to be done every time a new p
Aims: Stratifying renal damage in type 2 diabetes is challenging due to overlapping features between diabetic nephropathy (DN) and non-diabetic renal disease (NDRD). While miR-27b-3p modulates kidney fibrosis in DN through the lysine63 ubiquitination pathway, its upstream regulation and diagnostic relevance remain unclear. Methods: In a biopsy-verified cohort of 231 chronic kidney disease (CKD) pa
