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Amyloid plaques and neurofibrillary tangles (NFTs) in the brain are the neuropathological hallmarks of Alzheimer's disease (AD). Amyloid plaques are composed of β-amyloid peptides (Aβ), while NFTs contain hyperphosphorylated tau proteins. Patients with familial AD who have mutations in the amyloid precursor protein (APP) gene have either increased production of Aβ or generate more aggregation-pron

While it is understood that cities generate the majority of carbon emissions, for most cities, towns, and rural areas around the world no carbon footprint (CF) has been estimated. The Gridded Global Model of City Footprints (GGMCF) presented here downscales national CFs into a 250 m gridded model using data on population, purchasing power, and existing subnational CF studies from the US, China, EU

A comprehensive, three-dimensional model of a proton exchange membrane (PEM) fuel cell based on a steady state code has been developed. The model is validated and further be applied to investigate the effects of various porosity of the gas diffusion layer (GDL) below channel land areas, on thermal diffusivity, temperature distribution, oxygen diffusion coefficient, oxygen concentration, activation

Drop fragmentation in high intensity turbulent emulsification processing equipment-such as rotor-stator mixers (RSMs)-has traditionally been described in terms of a stress balance; between the stabilizing stress of the drop and the time-averaged turbulent stress at the most intense position of the flow. As shown in part 1 of this series, this approach is often a fruitful first approximation. Howev

Protein–protein interactions play important roles in bacterial pathogenesis. Surface-bound or secreted bacterial proteins are key in mediating bacterial virulence. Thus, these factors are of high importance to study in order to elucidate the molecular mechanisms behind bacterial pathogenesis. Here, we present a protein-based strategy that can be used to identify and isolate bacterial proteins of i

The classification of 2 532 new settlements in the Census of India 2011 as 'urban', and specifically as 'Census Towns', has brought small and emerging urban centres back into the purview of urban studies and urban development in India. Taking this to be a point of entry, this article seeks to explore how the urban has been framed and approached from different and competing epistemological standpoi

The Mediterranean basin is a hotspot of biodiversity, fuelled by climatic oscillation and geological change over the past 20 million years. Wall lizards of the genus Podarcis are among the most abundant, diverse, and conspicuous Mediterranean fauna. Here, we unravel the remarkably entangled evolutionary history of wall lizards by sequencing genomes of 34 major lineages covering 26 species. We demo

Ligand selectivity among the highly conserved galectins has been an ever-challenging objective. For galectin-8, a protein prevalent in both pathology and tissue distribution, we report phthalazinone-galactals that show excellent selectivity for the galectin-8N-terminal domain. A dissection of structure–activity relationships of the phthalazinone and an extensive molecular dynamics meta-analysis ac

Up to 8% of all patients with colorectal cancer have peritoneal carcinomatosis (PC) as the only site of disease at some point in time. Traditional treatment by limited palliative surgery and systemic chemotherapy has poor results with few patients surviving longer than 3 years. Complete cytoreductive surgery combined with Hyperthermic Intra Peritoneal Chemotherapy (HIPEC), using Mitomycin C, follo