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BACKGROUND: Eosinophils have a typical content of granule-bound, cytotoxic, cationic proteins which may, when released to the external milieu, play roles in diseases such as asthma and parasitic infestation. Therefore, we have investigated possible mechanisms by which their release is regulated in eosinophils. METHODS: The enzyme-linked immunosorbent assay (ELISA) was used to detect released eosin

Efficient policy instruments for reducing the emission of greenhouse gases are essential for the realisation of a successful climate policy. General economic policy instruments have the potential for providing efficient emission reduction as they equalise marginal costs for emission reduction between different actors. They also provide incentives for a great variety of responses such as energy eff

The hormone leptin has been shown to be an afferent signal in a negative-feedback loop regulating body weight, and consequently, the administration of the gene product for the treatment of obesity has recently attracted considerable attention. Leptin is produced by adipocytes in response to increased trigyceride storage, and appears to affect body weight primarily through target cells in the hypot

ydrophobically modified polymers (HM-P) typically behave as thickeners in a wide range of systems. The thickening effect in an aqueous solution of this kind of polymer depends on intermolecular hydrophobic associations and also on chain entanglements if the polymer concentration is significantly above the overlap concentration. In the present investigation a rather short end-capped polymer has bee

The aim of the mini review is to more precisely determine the relationship between exocrine pancreas function and the growth of young pigs. In order to do so, it is necessary to clarify the components, pathways and messengers involved in the CCK-dependent neuro-hormonal regulation of the exocrine pancreas in the growing pigs. These mechanisms are largely unknown, and the role of CCK has been quest

Urbanisation and industrialisation has led people spending more time indoors than ever before. Many buildings have small windows and contain large windowless spaces. Therefore, the natural daylight outdoors has to be replaced by light from artificial sources. If light affected vision only, this situation would be difficult enough. Since light also affects both well-being and health, the design of

Meniscectomy is recognized as an important risk factor for the development of knee osteoarthritis (OA), a disease that traditionally has been considered as a simple "wear and tear" phenomenon. However, despite numerous reports, little evidence has been presented that a limited meniscal resection, compared with a more extensive resection, reduces the risk of OA by preserving meniscal function. Why?

Popular Abstract in Swedish Genteknik innebär stora möjligheter att förändra och förbättra organismers egenskaper. Genom att i en organism föra in en främmande gen kan man ge den helt nya egenskaper som den aldrig skulle ha förvärvat på naturlig väg. Genmodifierade bakterier odlas idag industriellt i stora bioreaktorer för tillverkning av olika proteiner, till exempel insulin till diabetiker, humaVitreoscilla is an obligate aerobic bacterium living in oxygen-poor environments such as stagnant ponds and decaying vegetable matter. Vitreoscilla expresses a homodimeric haemoglobin (VHb) when subjected to oxygen-limited conditions. In several organisms, expression of VHb has been shown to increase microaerobic cell growth and enhance oxygen-dependent cell metabolism. Moreover, the presence of V

Popular Abstract in Swedish Artros (ledsvikt) är en vanligt förekommande ledsjukdom, som ofta leder till nedbrytning av ledbrosk och förändring i ledstrukturen i övrigt. Sjukdomen kan medföra symptom som smärta, svullnad och stelhet, vilket leder till nedsatt ledfunktion. I Sverige utförs det per år ca 15000 protesoperationer (utbyte till konstgjord led) p.g.a. artros. Tidigare studier har visat aMeniscectomy is recognized as an important risk factor for the development of knee osteoarthritis (OA), a disease that traditionally has been considered as a simple "wear and tear" phenomenon. However, despite numerous reports, little evidence has been presented that a limited meniscal resection, compared with a more extensive resection, reduces the risk of OA by preserving meniscal function. Why?