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Although it is well established that unique B-cell lineages develop through distinct regulatory mechanisms during embryonic development, much less is understood about the differences between embryonic and adult B-cell progenitor cells, likely to underpin the genetics and biology of infant and childhood PreB acute lymphoblastic leukemia (PreB-ALL), initiated by distinct leukemia-initiating transloc
Gitelman's syndrome is an autosomal recessive disorder characterized by electrolyte disturbances and low blood pressure. The disease is caused by homozygous or compound heterozygous inactivating mutations in the thiazide-sensitive NaCl-cotransporter gene leading to reduced renal sodium reabsorption. We report 4 patients with Gitelman's syndrome from southern Sweden, all in whom we identified compo
Despite the widespread dissemination of clinical practice guidelines on the prevention and treatment of cardiovascular disease (CVD), CVD causes one third of deaths worldwide and almost half of all deaths in the developed world. It is therefore likely that, although some aspects of CVD management have improved, there is still a significant shortfall between what is known about CVD prevention and w
Problems with bottlenecks in district heating networks occur when the pipes have too small dimensions to sufficiently meet customer needs. This may result in insufficient differential pressure in DH areas attached to these pipes. Bottlenecks are especially common in expanding DH networks, as previously sufficient pipe diameters may become too small when more DH consumers are connected to the DH ne
Background: Soils are important global carbon pools that are under threat from intensive land use through a variety of agricultural practices. Sustainable management of agricultural soils may have the potential to mitigate climate change through increased carbon sequestration and increase their fertility. Among management practices to increase carbon sequestration, crop rotation designs have often
Papillorenal syndrome (PAPRS; Mendelian Inheritance in Man [MIM] 120330) is an autosomal dominant disease characterised by the presence of congenital renal and optic nerve abnormalities associated with mutations of the PAX2 gene. In this article, the authors present four patients with PAPRS who are carriers of three new PAX2 mutations, as well as another patient with a possible non-pathogenic vari
Abstract Authors: Alexandra Jönsson & Emmeli Trobäck Title: We never force a child [translated title] Supervisor: Claes Levin Assessor: Kristina Göransson Our purpose with this paper was to try to get a better understanding of how a social worker acts and thinks in their assessments. Especially in the interaction between a foster child and the biological parents along with what role the child
Background Arriva DK currently has a decentralized organization where each depot is responsible for the inventory control of their spare parts. This type of organization often presents challenges when it comes to control and management. Arriva DK suffers from high order costs due to lack of coordination between the depots and the suppliers. To address these issues Arriva wants to introduce a centr
This study examines the special for small and medium-sized enterprises (SME) in the European Union (EU) provided for in the Sixth Directive and the VAT Directive. The author goes through three problems regarding the special scheme and thereby the thesis is divided in three parts. The aim of the first part is to analyze the current provisions regarding the special scheme for SME by following the h
Popular Abstract in Swedish Målet med kollektivtrafik är bl a att anordna transportförsörjning för alla samhällsgrupper på ett samhällsekonomiskt effektivt vis. En grupp medborgare är rullstolsburna resenärer, vars speciella förutsättningar ställer särskilda krav på transportsystemets utformning. För att utröna dessa speciella förutsättningar på ett ansvarsfullt sätt, är det viktigt att man anläggEliciting wheelchair-seated passengers’ perspective of safety and comfort is both useful and mandatory, particularly for researchers, clinicians, transit authorities, and for operators during purchase and use of vehicle technologies in existing and planned future transport systems. Therefore, the overarching objective of this thesis was to delineate the question of safety and comfort as perceived
Sammanfattning Syftet med mervärdesskatten är att skatten ska belasta försäljningen till konsumenter och på så sätt fungera som en generell konsumtionsskatt. När en beskattningsbar person köper varor och tjänster betalar han mervärdesskatt på varorna och tjänsterna. Denna mervärdesskatt kallas för ingående mervärdesskatt. Det är den ingående mervärdesskatten som är avdragsgill, förutsatt att den bVAT should work as a general consumption tax and the tax burden should fall on the final consumers. A taxable person will have to pay VAT when purchasing goods and services. This VAT is called input tax and it is the input tax that is deductible. The right to deduct is central to the forward shifting of the VAT. When ML and the VAT Directive were created there was a strong desire to ensure that th
Lime-cement mixing is a method used for ground improvement of clay soils. Before mixing at a field site, laboratory samples are prepared and tested to decide the amount of lime-cement binder needed to reach the desired material strength. Strength measurements are not possible before a sample hardens, and the test process to predict final strength takes 30 days. Resistivity measurements are possibl
