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HIV-2 infection will progress to AIDS in most patients without treatment, albeit at approximately half the rate of HIV-1 infection. HIV-2 capsid (p26) amino acid polymorphisms are associated with lower viral loads and enhanced processing of T cell epitopes, which may lead to protective Gag-specific T cell responses common in slower progressors. Lower virus evolutionary rates, and positive selectio

The present National Innovation Policy (henceforth called PNI) was instituted in Brazil by Decree No. 10.537, of October 28, 2020, within the federal public administration. The policy's objective is to guide, coordinate and articulate strategies, programs, and actions across several public entities to foster innovation in the productive sector. Thus, it aims to increase the productivity and compet

Background: Fracture risk assessment is still far from perfect within the geriatric population. The overall aim of this study is to better identify older women at risk for fractures, using a quantitative measure of frailty in conjunction with the web-based Fracture Risk Assessment Tool (FRAX®). Methods: This study was performed in the Osteoporosis Risk Assessment (OPRA) cohort of n = 1023, 75-year

PrologMikrovågs-hypertermi och strålbehandling (1980–1990)Min tidiga forskning inom medicinsk strålningsfysik ledde till kombinerad behandling av bröstcancer-recidiv med mikrovågsinducerad hypertermi och lågdos strålning (30 Gy). Kliniska försök inleddes med patienter som tidigare fått full stråldos (60 Gy). Utrustningen visades upp för kung Carl XVI Gustaf och drottning Silvia på Forskningens DagThis story has its origin in my presentation at the 1983 Research Day in Lund, to HM King XIV Gustav on our development of microwave-induced hyperthermia treatment of breast cancer recurrence, which brought me together with Professor Leif G. Salford, whose presentation was next to mine. Shortly before the turn of the millennium, Leif Salford initiated a clinical trial "Brain Immune Gene Tumour

Popular Abstract in Swedish En halvledare är en kristall vars egenskaper till stor del bestäms av dess bandgap, som i någon mening kan ses som lägesenergin hos fria elektroner i kristallen. En kvantprick är en liten volym halvledarmaterial som är inbäddad i ett annat material med större bandgap. Det gör att volymen attraherar laddning eftersom elektroner (precis som allt annat) helst minimerar sin

Background: The wide range of antibody specificity and affinity results from the differing shapes and chemical compositions of their binding sites. These shapes range from discrete grooves in antibodies elicited by linear oligomers of nucleotides and carbohydrates to shallow depressions or flat surfaces for accommodation of proteins: peptides and large organic compounds. Objectives: To determine t

Phylogenies are central to many disciplines in biology. While disciplines such as systematics are focused on phylogenetic hypotheses themselves, other disciplines depend on robust and well-supported phylogenies in order to put biological data into evolutionary context through phylogenetic comparative studies. Examples of such fields are macroevolutionary research e.g. studying the evolution of a f

Objective: To investigate the feasibility of active heart sparing (AHS) planning in patients with locally advanced and centrally located NSCLC receiving standard definitive radiotherapy (RT), while maintaining or improving appropriate lung, esophagus, and spinal cord constraints and planning target volume (PTV) coverage intent. Methods and materials: A total of 27 patients with stage IIIA/B NSCLC

Throughout the last decades, the social responsibility of corporations has undergone significant changes. From revolving around self-regulation, voluntariness, and soft law, the regulatory landscape has expanded to involve harder demands on corporations, such as mandatory sustainability due diligence. This thesis considers these changes as a hardening of Corporate Social Responsibility (CSR), and