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Due to the scarcity of reliable palaeoecological and climatic proxy records from the Eastern Baltic covering the Holocene, there has been increased interest for multi-proxy studies in the region to detect local to regional environmental changes. The Čepkeliai wetland complex, SE Lithuania, provides an uninterrupted Holocene sediment sequence, which is used here to reconstruct palaeoenvironmental h
Background: Mesenchymal stromal cells (MSCs) are currently being evaluated in numerous pre-clinical and clinical cell-based therapy studies. Furthermore, there is an increasing interest in exploring alternative uses of these cells in disease modelling, pharmaceutical screening, and regenerative medicine by applying reprogramming technologies. However, the limited availability of MSCs from various
Popular Abstract in Swedish Exponeringsskattning för att hindra uppkomst av belastningsskador Skador på muskler som uppkommer av olämpliga arbetsrörelser och arbetsställningar (belastningsskador) utgör ett stort problem i alla industrialiserade länder. Definitionen av vad som innefattas i begreppet arbetsskada varierar mellan olika länder, varför det är svårt att göra jämförelser. Kostnader för ar
This thesis is an approach to improve electric hybrid vehicles with respect to fuel consumption and to fulfil the future intended NOX emission regulations. It is based upon the conclusions made in the licentiate thesis Analysing Hybrid Drive System Topologies (Jonasson, 2002). The study in this thesis is restricted to a parallel hybrid vehicle equipped with a diesel engine, two electric machines
A sustainable development of the built environment asks for changes in urban residents’ mobility patterns. The extensive use of the car contributes to sedentary lifestyle and negative environmental impact in many respects. Children living in urban areas are faced with limits of their independent use of the environment both in terms of travel and outdoor play. Many parents hold favourable attitudes
Outstanding economic growth in China has its price to pay. By prioritizing economic growth as number-one issue, complementing cheap energy consumption has undeniably been side-by-side. Although the energy base on fossil-fuel energy consumption, together with inefficient technology has pushed forward China to lifting millions of the population out of poverty, it has also mounted emissions in China,
The policy of the European Union concerning promotion of employment is among other things to support and complement the member states in matters relating to workers' right of participation. For this reason the EU has developed the open method of co-ordination (OMC), which entails a form of cooperation by comparing studies of national systems and exchange of experiences to reach the goals of th
The connection between human rights and development co-operation in the context of the European Union, which are the matters concerned in this paper, has proven to be both a contentious and complex subject. Human rights and development co-operation are two areas of practice and law, which in the past of the EU has not had an explicit relationship. Over the passed decade or so, the connection betwe
Popular Abstract in Swedish Varje år insjuknar mer än 8000 kvinnor i Sverige i bröstcancer, och 5 år efter diagnos är nära 90% fortfarande i livet. Trots att prognosen för majoriteten av patienterna är god, dör 1400 kvinnor årligen av bröstcancer. Till följd av detta pågår mycket forskningsarbete för att finna faktorer som bättre kan förutsäga prognos, prognostiska studier, men även för att finna
OBJECTIVE-The Type 1 Diabetes Genetics Consortium has collected type 1 diabetic families worldwide for genetic analysis. The major genetic determinants of type 1 diabetes are alleles at the HLA-DRB1 and DQB1 loci, with both susceptible and protective DR-DQ haplotypes present in all human populations. The aim of this study is to estimate the risk conferred by specific DR-DQ haplotypes and genotypes
The exposure to fragrances is widespread and contact allergy to fragrance substances affects 1–4% of the general population. Many fragrance substances are volatile and it can therefore be suspected that they may evaporate from petrolatum patch test preparations applied in test chambers. In the first two papers included in this thesis the aims were to i) to investigate the stability of fragrance pr
Allergic rhinitis is an inflammatory nasal disorder in which a range of different cells participates. A variety of approaches has been used to monitor nasal inflammation objectively to investigate disease processes and to evaluate the effect of therapeutic intervention. These approaches include nasal lavage, nasal cytology, and nasal biopsy, together with the more recently established measurement
Autoignition in SI engines is an abnormal combustion mode and may lead to engine knock which is an undesired phenomenon in SI engines. It may cause damage and it is a source of noise in engines. Knock limits the compression ratio of the engine and a low compression ratio means low fuel conversion efficiency of the engine. This thesis presents a theoretical investigation about the modeling of the e
Formation of incipient charnockite in Söndrum, SW Sweden and the Kerala Khondalite Belt (KKB), S. India is accompanied by zircon growth. The age of the dehydration event is constrained by dating newly formed zircon to 1397±4 Ma (2?, MSWD=1.7) in Söndrum and ca. 520-510 Ma in S. India by secondary ionization mass spectrometry (SIMS). The formation of incipient charnockites correlates with regional
Popular science summary Do metformin and phenformin cause toxicity to mitochondria of human blood cells? Metformin and phenformin are anti-diabetic drugs associated with lactic acidosis as a rare side effect. This side effect is thought to be due to drug-induced mitochondrial dysfunction. In this project, the mitochondrial toxicity of metformin and phenformin was assessed in human blood cells. I
In order to increase the understanding of suicidal behaviour, the general aim of the thesis is to gain a profound knowledge of the suicidal individual, and hence to find and ensure a preventive strategy. This will be accomplished by finding and trying new methods for evaluation of suicide risk. The Suicide Assessments Scale, SUAS, and a new self-rating version, SUAS-S were tested. These scales ar
Over 800 million people in the developing world are affected by chronic hunger today. Hunger reduction is necessary for accelerating development and poverty reduction. It has been argued that genetically modified food (GM food) could be the solution to the third world hunger problem. Scientific progress in modern biotechnology has resulted in new medical treatments and vaccines. Biotechnology in t
