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Plasma biomarkers that reflect molecular states of the cardiovascular system are central for clinical decision making. Routinely used plasma biomarkers include troponins, natriuretic peptides, and lipoprotein particles, yet interrogate only a modest subset of pathways relevant to cardiovascular disease. Systematic profiling of a larger portion of circulating plasma proteins (the plasma proteome) w
Background: There is a need for a prehospital stroke test that in addition to high sensitivity for stroke, also is able to communicate stroke severity similar to the National Institute of Health Stroke Scale (NIHSS). Methods: The PreHospital Ambulance Stroke Test (PreHAST), an eight item test based on NIHSS, which scores stroke severity from 0-19 points, was designed and adapted for the ambulance
Popular Abstract in Swedish Det är känt sedan tidigare att komponenter från blodkärlets bindväv på olika sätt kan påverka sjukdomstillstånd som uppkommer i kärlväggen. En av dessa sjukdomar är ateroskleros (åderförkalkning), som genom sina följdsjukdomar (hjärtinfarkt, kärlkramp, stroke mm) utgör den vanligaste dödsorsaken i västvärlden. I den här avhandlingen studeras hur komponenter av kärlväggeThe composition of the vascular extracellular matrix (ECM) is altered during remodeling conditions such as atherosclerosis. The changed ECM regulates events that are important for the progression of disease including smooth muscle cell (SMC) behaviour and collagen fiber formation. The overall aim of this project was to relate changes in the composition of ECM in the arterial wall to processes duri
Popular Abstract in Swedish Urinvägsinfektioner (UVI) är en av våra vanligaste infektionssjukdomar och orsakas oftast av bakterien Escherichia coli (E. coli). Infektionernas svårighetsgrad varierar, beroende på samspelet mellan bakterie och värd. Njurbäckeninflammation kan orsaka allvarliga störningar av njurfunktionen och kan till och med vara livshotande. Blåskatarr är en mindre allvarlig sjukdoUrinary tract infections (UTI) are among the most common bacterial infections in humans. Symptomatic UTIs may be acute, recurrent or chronic but the most frequent form of UTI is asymptomatic bacteruria (ABU). In ABU, the mucosa remains inert, despite the presence of large bacterial numbers in urine. The difference in disease severity reflects the virulence of the infecting strain and the propensit
The shortfalls in the quality, quantity, and reliability of agriculture performance data are neither new nor confined to Sub-Saharan Africa (SSA). It is, however, a more dire challenge given the overwhelming importance of agriculture in the economies of most countries in the region in terms of food security and poverty reduction. While farmers’ self-reported (SR) data on crop outputs and farm size
Heterogeneity among NPY (and PYY) receptors was first proposed on the basis of studies on sympathetic neuroeffector junctions, where NPY (and PYY) can exert three types of action: 1) a direct (e.g., vasoconstrictor) response; 2) a postjunctional potentiating effect on NE-evoked vasoconstriction; and 3) a prejunctional suppression of stimulated NE release; the two latter phenomena are probably reci
The carbon cycle of tropical terrestrial vegetation plays a vital role in the storage and exchange of atmospheric CO2. But large uncertainties surround the impacts of land-use change emissions, climate warming, the frequency of droughts, and CO2 fertilization. This culminates in poorly quantified carbon stocks and carbon fluxes even for the major ecosystems of Africa (savannas and tropical evergre
Background: Research has indicated that interactive, computerized case simulations using immersive virtual reality (VR) technology may be beneficial in the augmentation of conventional methods of assessment and treatment in forensic psychiatry, primarily through providing an engaging and safe environment in which the user can practice and learn skills and behaviors. However, there does not appear
Introduction: In contrast to the intake of sugar-sweetened beverages (SSBs), the evidence linking added sugar intake to the risk of cardiometabolic disease (primarily referring to cardiovascular disease and type 2 diabetes (T2D)) is contradictory. Aim: The aim of this thesis is to elucidate the role of added sugar intake in the risk for cardiometabolic diseases. To obtain further understanding of
Structural adjustment (SA) — or macroeconomic reform — has become a dominant characteristic especially in developing countries, where national economies are being reshaped to a common discipline regardless of local circumstances. Within this context, the paper examines the impact of structural adjustment on disaster vulnerability in the urban sector, through examining some structural consideration
Exposure to airborne particles causes detrimental health effects, hence their assessment in indoor environments, where people spend most of the time, is important. The influence of energy renovation and occupants' activities on airborne particle concentrations was assessed in seven occupied Swedish residences. Ultrafine particle (UFP, <100 nm) number concentrations, PM2.5 (<2.5 μm) and black carbo
Tribology in the railway system is of increasing interest in the new railway era due to the demand for higher speed and load capacity. Since railway vehicles operate in an open environment, their performance depends greatly on temperature, humidity and natural and artificial contaminants. Meanwhile, the “feedback” of railway vehicles to the surroundings, such as noise and airborne particles, is of
