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BACKGROUND: Post-acute sequelae of SARS-CoV-2 infection, or long COVID, include diverse symptoms and remain a major concern worldwide. This study investigates the occurrence of depression, anxiety, fatigue, and headache 1 year prior to the COVID-19 pandemic (2019), 12 months prior to, and 6 months after long COVID diagnosis in individuals diagnosed with long COVID and matched population-based cont
Forward osmosis (FO) and membrane distillation (MD) have emerged as promising processes for seawater desalination. One of the key factors influencing the FO process is the selection of a suitable draw solution (DS), which should exhibit high osmotic pressure and easy regeneration through a secondary process such as MD. Thermo-responsive polymers having ethylene oxide (EO) and propylene oxide (PO)
Background: We set out to profile the immune mechanisms active in treatment-naïve oligoarticular JIA (oJIA) to improve the knowledge of its immunopathogenesis, to identify potential biomarkers that can aid diagnosis, predictions and that correlate with clinical disease parameters. Methods: Using Olink proteomics (inflammation panel measuring 92 markers), we defined and compared the inflammation pr
Background: Amyotrophic lateral sclerosis (ALS) is invariably fatal but there are large variations in the rate of progression. The lack of predictability can make it difficult to plan clinical interventions. This includes the requirement for gastrostomy where early or late placement can adversely impact quality of life and survival. Methods: We designed a model to predict the timing of gastrostomy
Objective: To investigate the development of sexual activity, sexual function, and body image in women with primary vulvar cancer from the time of diagnosis to 24 months after the end of treatment. Methods: This nationwide prospective cohort study assessed health-related quality of life in women with newly diagnosed vulvar cancer using validated patient-reported outcome measures (EORTC-QLQ-VU34 [E
Objective Individuals with SLE commonly report chest pain or discomfort. We performed cardiovascular magnetic resonance (CMR) to differentiate coronary artery disease (CAD), coronary microvascular dysfunction (CMD), pericarditis and myocarditis in individuals with SLE who presented with chest symptoms. We also assessed the clinical utility of CMR. Methods Adults with SLE were included if reporting
Introduction: Food systems strongly influence both human and planetary health. Unhealthy diets aremajor risk factors for chronic disease and mortality, while food production contributes substantially togreenhouse gas emissions (GHGE), and other negative environmental impacts. Adopting moresustainable dietary patterns, such as the EAT-Lancet diet, has been proposed as part of the solution, butuncer
Background. Treatment of childhood medulloblastoma has evolved to reduce neurotoxicity while improving survival. However, the impact of evolving therapies on late neurocognitive outcomes and adult functional independence remains unknown. Methods. Adult survivors of childhood medulloblastoma (n = 505; median [minimum–maximum] age, 29 [18–46] years) and sibling controls (n = 727; 32 [18–58] years) f
INTRODUCTION: In Sweden, most older adults continue to age in dwellings they have lived in for many years, with a small proportion relocating. Longitudinal studies examining relocation histories, especially among younger old adults and those beyond frail populations, are scarce. This study aimed to describe individuals who stayed in their homes (stayers) and those who relocated (movers) while iden
Background: Influenza ranges from a mild and self-limiting infection to a life-threatening disease with high mortality despite intensive care. Conclusive data on the association between influenza type/subtype and mortality among adults treated at intensive care units (ICU) is lacking. Objectives: To investigate the mortality in adults admitted to ICU with laboratory-confirmed influenza during thre
Objective: To evaluate the impact of pregestational diabetes on duration of active labour (DAL) in induced and spontaneous labour and to compare caesarean section (CS) rates and indications between women with and without diabetes. Design: A population-based cohort study. Setting: Sweden. Population: 243 537 nulliparous women, registered in the Swedish Pregnancy Register, who delivered a singleton
Background Although the role of smoking as a risk factor for emphysema in α1-antitrypsin deficiency (AATD) is well known, never-smokers with severe AATD may also develop lung disease, ranging from mild asymptomatic disease to severe emphysema. Methods We performed a cross-sectional and observational study to analyse the characteristics of the population of never-smoker severe AATD (genotype) indiv
INTRODUCTION: Effective management of chronic breathlessness requires understanding people's activity limitations. This study evaluated the extent to which chronic breathlessness limits people's self-reported everyday activities.METHODS: A web-based, cross-sectional survey (adults ≥18 years). Recruitment was through a marketing research company, stratified to the 2016 Australian Census for key dem
Introduction: Different strategies in prophylaxis for haemophilia among countries may affect long-term outcome. Aim: The aim of this study is to compare joint health in persons with severe haemophilia (PwSH) between Sweden and Greece, based on different approaches on prophylaxis initiation and management. Methods: Data were extracted from the PedNet Registry, which collects patient data prospectiv
Objectives: Within the first phase of developing classification criteria for Early-stage Symptomatic Knee Osteoarthritis, among individuals with knee osteoarthritis (OA) we explored: 1) symptoms within the first year of noticing their knee(s); 2) features that indicated OA was the cause; and 3) timing and reasons that initially prompted seeking healthcare. Design: We conducted a cross-sectional on
Climate change and urbanization are two major challenges when planning for sustainable energy transition in cities. The common approach for energy demand estimation is using only typical meso-scale weather data in building energy models (BEMs), which underestimates the impacts of extreme climate and microclimate variations. To quantify the impacts of such underestimation on assessing the future en
Background: The requirement concerning formal education for emergency medical dispatcher (EMD) is debated and varies, both nationally and internationally. There are few studies on the outcomes of emergency medical dispatching in relation to professional background. This study aimed to compare calls handled by an EMD with and without support by a registered nurse (RN), with respect to priority leve
Survival after blood or marrow transplantation (BMT) for inborn errors of metabolism (IEM) is excellent; however, the burden of morbidity in long-term survivors of BMT for IEM remains understudied. This study examined the risk of chronic health conditions (CHC) in ≥2-year survivors of allogeneic BMT for IEM performed between 1974 and 2014 using the BMT Survivor Study. In this retrospective cohort
Background: The neurobiological origins of the early and predominant behavioral changes seen in the behavioral variant of Alzheimer’s disease (bvAD) remain unclear. A selective loss of Von Economo neurons (VENs) and phylogenetically related neurons have been observed in behavioral variant frontotemporal dementia (bvFTD) and several psychiatric diseases. Here, we assessed whether these specific neu
