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Popular Abstract in Swedish Det finns ett starkt samband mellan en förenings struktur och dess egenskaper. En detaljerad tredimensionell bild av en förenings struktur på molekylnivå är därför grundläggande information för att förstå dess reaktivitet, stabilitet och fysikaliska egenskaper. Röntgenkristallografi är ett utmärkt redskap för att ta reda på ett ämnes struktur i en kristall. En kristallsThis thesis focuses on i) the effect of packing on the molecular geometry ii) packing arrangements of neutral Pd(II) and Pt(II) complexes iii) the trans influence in Pt(II) complexes iv) the differences in bonding in corresponding Pd(II) and Pt(II) complexes and v) the geometry of Pd(II) complexes with potential catalytic properties. Detailed three-dimensional structural information at the atomic

Popular Abstract in Swedish Ett högt fiberintag från grönsaker, frukt och sädesslag som havre och korn minskar risken för hjärt- och kärlsjukdomar och typ 2 diabetes. Havre och korn har en hög halt av lösliga kostfiber, så kallade beta-glukaner (beta-glukaner) och studier har visat att beta-glukaner har intressanta hälsoeffekter. Ett dagligt intag av beta-glukaner från havre eller korn kan sänka kSince soluble fibre in the form of the cereal beta-glucans found in oats and barley has been shown to have a positive effect on lipid and glucose metabolism, people at risk of developing cardiovascular diseases or diabetes might benefit from that a variety of palatable food products containing beta-glucans being available to them. The aim of the papers presented in the thesis was to evaluate the m

Objective: The authors sought to clarify the sources of parent-offspring resemblance for drug abuse, alcohol use disorders, and criminal behavior, using a novel genetic-epidemiological design. Method: Using national registries, the authors identified rates of drug abuse, alcohol use disorders, and criminal behavior in 41,360 Swedish individuals born between 1960 and 1990 and raised in triparental

Background: Sweden is a high endemic region for multiple sclerosis (MS), a neurologic disorder characterized by repeated inflammatory episodes affecting the CNS. The disease has its peak age of onset at approximately 30 years and affects women twice as often as men. The young age of onset makes MS one of the major causes of reduced capacity to work due to neurologic disease in Western society. Nat

Brown C, Hasson H, Thyselius V, Almborg A-H. Post-stroke depression and functional independence: a conundrum. Acta Neurol Scand: DOI: 10.1111/j.1600-0404.2011.01595.x. © 2011 John Wiley & Sons A/S. Objectives - People who suffer a stroke are at risk of developing post-stroke depression (PSD). Not only does this lower their quality of life but it also increases their risk of another stroke or d

Objectives To describe clinical history and ultrasound findings in patients with tubal carcinoma. Methods Patients with a histological diagnosis of tubal cancer who had undergone preoperative ultrasound examination were identified from the databases of 13 ultrasound centers. The tumors were described by the principal investigator at each contributing center on the basis of ultrasound images, ultra

Objective: This study aimed to evaluate the outcome and predisposing factors related to perioperative bleeding in patients treated with endovascular aneurysm repair (VAR) for ruptured and non-ruptured abdominal aortic aneurysm (AAA). Design: This was a retrospective cohort study. Methods: A total of 525 consecutive patients (73% elective) with AAA underwent EVAR at two vascular centres from 2008 t

OBJECTIVES: Deteriorating ward patients are at increased risk. Electronic automated advisory vital signs monitors may help identify such patients and improve their outcomes. SETTING: A total of 349 beds, in 12 general wards in ten hospitals in the United States, Europe, and Australia. PATIENTS: Cohort of 18,305 patients. DESIGN: Before-and-after controlled trial. INTERVENTION: We deployed

PURPOSE: To investigate whether separate physical tests of the lower extremities, that assess movement speed and postural control, were associated with cognitive impairment in older community-dwelling subjects. SUBJECTS AND METHODS: In this population-based, cross-sectional, cohort study, the following items were assessed: walking speed, walking 2 × 15 m, Timed Up and Go (TUG) at self-selected an

CONTEXT: The prevalence of obesity among adolescents has increased and we lack effective treatments. OBJECTIVE: To determine if gastric bypass is safe and effective for an unselected cohort of adolescents with morbid obesity in specialized health care. DESIGN, SETTING AND PATIENTS: Intervention study for 81 adolescents (13-18 years) with a body mass index (BMI) range 36-69 kg m(-2) undergoing lapa

Background: Polymorphisms in and around the CTLA-4 gene have previously been associated to TiD and AITD in several populations. One such single nucleotide polymorphism ( SNP), CT60, has been reported to affect the expression level ratio of the soluble ( sCTLA- 4) to full length CTLA- 4 ( flCTLA- 4) isoforms. The aims of our study were to replicate the association previously published by Ueda et al

Popular Abstract in Swedish De personer som ingår i undersökningen har gemensamt att de har erfarenheter av flera års avancerat narkotikamissbruk, varit drogfria i minst två år samt att de idag är socialt integrerade. Det faktum att de lyckats sluta missbruka narkotika och idag lever "vanliga liv" innebär att de tillhör en grupp som hitintills fått mycket liten uppmärksamhet av missbruksforskningeAim of the study, background, theory and method The two aims of this study are to describe and analyse: i) how drug abusers have transformed their lives from the time when they did not use drugs, to becoming drug abusers, and finally leaving drugs behind them; and ii) what it means to be socially integrated with one's experience of having been a drug abuser. The women and men who participated in

Ionizing radiation is a well-known risk factor for sarcoma development. To investigate whether radiation-associated sarcomas are characterized by chromosome aberrations that distinguish them from de novo sarcomas, we identified those patients in our series of more than 500 cytogenetically abnormal sarcomas that fulfilled the following criteria: (1) each patient should have been irradiated for anot

BACKGROUND: Pulmonary hypertension may result in significant morbidity and mortality after pediatric cardiac surgery. The objective of this study was to determine the incidence and outcome of severe pulmonary hypertension, defined as a ratio of pulmonary to systemic arterial pressure equal to or greater than 1.0, after cardiac surgery in children. METHODS: Data from all children younger than 18 ye

Popular Abstract in English Proteins are molecular machines of the human body which regulate all life sustaining processes such as energy production, communication, transport of essential molecules, defense against microbes, etc. They are built by small molecular units called amino acids, bound together like pearls on a necklace. Each amino acid consists of a common part and a unique side chain. TAnisotropic protein interactions have a strong orientation dependence resulting from an uneven distribution of charged and hydrophobic residues on the protein surface. They play an important role in protein behaviors such as protein association, surface adsorption and phase separation. In this thesis, we have studied the effect of anisotropic interactions on the behavior of various proteins mainly

Popular Abstract in Swedish Alla levande organismer har DNA, och eftersom DNA är livsnödvändigt måste det repareras om det blir skadat. Ultraviolett (UV) strålning från solen är en av de vanligaste orsakerna till att DNA skadas. De flesta skador på DNA som orsakas av UV-strålning utgörs av cyklobutan-pyrimidindimerer (CPD) eller (6-4)-fotoprodukter. Dessa skador består av två intilliggande baser sAll living organisms have DNA and since DNA is essential to life it must be repaired when damaged. UV radiation is one of the major DNA damaging agents, which photosynthetic organisms cannot avoid. The major UV-induced DNA lesions are cyclobutane pyrimidine dimers (CPDs) and (6-4) photoproducts (6-4PPs) and the main repair pathways of theses lesions involve photolyases and various excision repair

INTRODUCTION: Branched iliac stent-grafts (bSG) have recently been developed in order to preserve internal iliac artery (IIA) flow in patients with aneurysmal or short common iliac arteries. The aim of this study is to evaluate a single-center experience with bSG for the IIA. METHODS: Twenty-two male patients (70 (IQR 65-79) years old) underwent EVAR with 23 bSG (1 bilateral repair) between Septem

Jämförande mätningar med olika typer av fotmodeller har genomförts. Åtta olika laboratorier deltog. Storleken på de olika modellerna motsvarade skostorlekar från 41 till 44. Sex andra laboratorier var intresserade att deltaga men kunde inte genomföra mätningar vid tillfället. En databas skapades som gör det möjligt att fortlöpande tillföra resultat från mätningar med typer av andra skodon samt vidA limited Round Robin test has been carried out with different types of foot models. Eight laboratories were able to carry out tests. The foot models varied in sizes from 254 mm to 275 mm, representing boot sizes from 41 to 44. Six other laboratories were interested but were not able to carry out the tests within this study. A database has been created. New test results from other test laboratorie

UNLABELLED: The VDR is a candidate gene for osteoporosis. Here we studied five common polymorphisms of VDR in relation to calcium intake and vitamin D status in a population-based cohort of 3100 British women, but found no significant association with bone mass, bone loss, or fracture.INTRODUCTION: Population studies of vitamin D receptor (VDR) polymorphisms have produced conflicting results. We p

OBJECTIVE: This systematic review aimed to assess the clinical outcomes of branched endovascular aneurysm repair (BEVAR) with inner branches (iBEVAR) and inner/outer branches (oBEVAR).DATA SOURCES: A systematic literature review was performed using the electronic bibliographic databases MEDLINE, Embase, Scopus, Web of Science, and the Cochrane Library up to May 2024.REVIEW METHODS: The review was