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Next generation sequencing (NGS) methods have been widely used for diagnosis. As time and cost of sequencing has reduced sharply during the last decade, genome and exome-wide sequencing have increasingly been used. The genome and exome projects produce large amounts of variation data and the clinical relevance of large proportions of them are not known. Among various types of genetic variations, t
Using transition metals in organic synthesis has led to the discovery of new reactions. These novel reactions have enabled different valuable transformations to take place through short synthetic routes and most importantly using a small amount of the metal. This small amount is called a catalytic amount and the metal which is in the form of a complex (with an array of groups of atoms bonded to thNew palladium and nickel complexes based on unsymmetric PCN pincer ligands have been synthesized and fully characterized using different techniques. The substituents on the nitrogen side arm of the ligand have great influence on the cyclometallation and the reactivity of the new complexes particularly in case of nickel. The less sterically hindered PCNMe ligand enabled formation of the trivalent n
Importance: Neonatal hyperbilirubinemia can cause lifelong neurodevelopmental impairment (kernicterus) even in high-resource settings. A better understanding of the incidence and processes leading to kernicterus may help in the design of preventive measures.Objectives: To determine incidence rates of hazardous hyperbilirubinemia and kernicterus among near-term to term newborns and to evaluate heal
Mild to moderate renal impairment affects 10% of the general population. Renal impairment is difficult to detect because of the lack of symptoms, but it can be estimated by calculating the estimated glomerular filtration rate (eGFR) on the basis of plasma creatinine and/or cystatin C concentrations. Chronic kidney disease (CKD) is associated with an increased risk of development of cardiovascular
Importance: Accurate risk prediction of morbidity and mortality in patients with heart failure with preserved ejection fraction (HFpEF) may help clinicians risk stratify and inform care decisions. Objective: To develop and validate a novel prediction model for clinical outcomes in patients with HFpEF using routinely collected variables and to compare it with a biomarker-driven approach. Design, Se
This thesis focuses on design, processing and electro-optical investigations of two- and three-terminal photodetectors based on large arraysof around three million n+-i-n+ InP nanowires with embedded InAsP quantum heterostructures for broadband detection. The first part of thethesis work dealt with a general investigation of the room-temperature optoelectronic behavior of two-terminal photodetecto
We urgently need to move from a fossil-based to a bio-based society. From a Swedish perspective, a promising way forward are biorefineries with an integrated production of materials, chemicals, and energy from the softwood species Scots pine (Pinus sylvestris) and Norway spruce (Picea abies). A diverse set of process routes will be necessary to produce all intermediates and commercial products. In
Background: One of the challenges of the 21st century is the high turnover rate in the nursing profession due to burnout and mental illness. From a biopsychosocial perspective, an individual's personality is an important vulnerability-resilience factor that comprises four temperament traits (i.e., a person's emotional reactions) and three character traits (i.e., self-regulation systems). Indeed, d
This paper is a part of a larger project where we longitudinally (over seven years) analyze the implementation process of a policy instigating written assessment criteria for all courses in a traditional university faculty. The overarching question is: How does educational policy influence educational practice?The project adhere to a complex perspective on implementation (Gornitzka et al., 2005) a
Analytical chemistry is a sub-discipline of chemistry that even young schoolchildren encounter at an early stage in their education. Gravimetry and measurement uncertainties are aspects that form a part of such education, as well as measurements of pH and colorimetry. These are all an integral part of children’s early educational experiences, which shows the importance of this discipline within th
BACKGROUND: Reproductive factors have been shown to be differentially associated with risk of estrogen receptor (ER)-positive and ER-negative breast cancer. However, their associations with intrinsic-like subtypes are less clear.METHODS: Analyses included up to 23 353 cases and 71 072 controls pooled from 31 population-based case-control or cohort studies in the Breast Cancer Association Consortiu
Background: Adolescent major depressive disorder (MDD) is highly prevalent and associated with lifelong adversity. Evidence-based treatments exist, but accessible treatment alternatives are needed. We aimed to compare internet-based psychodynamic therapy (IPDT) with an established evidence-based treatment (internet-based cognitive behavioural therapy [ICBT]) for the treatment of adolescents with d
STUDY QUESTION: Does previous bariatric surgery (BS) in women affect cumulative live birth rate in IVF?SUMMARY ANSWER: Women having had BS seem to have the same cumulative live birth rate as non-operated women of the same BMI at IVF treatment.WHAT IS KNOWN ALREADY: Because of the perinatal risks of obesity to mother and infant as well as impaired outcomes of IVF, obese women are advised to reduce
Delirium is a serious and common condition in the intensive care unit (ICU), which affects 30-50 % of the patients and is associated with increased mortality and morbidity in the context of long-term outcomes. No evidence-based treatment for delirium exists, and currently, delirium is mainly treated pharmacologically with haloperidol, a typical antipsychotic agent. The “Agents Intervening against
Denna uppsats avser att utreda och beskriva förutsättningarna för återvinning av betalning av en skuld enligt 4 kap 10 § KonkL och att belysa hur regleringen brukar tolkas och tillämpas. Syftet är att redogöra för innebörden av bestämmelsens rekvisit, med fördjupning i vad som avses med ordinär betalning och hur det bedöms om en betalning är att anse som ordinär eller ej. Materialet i denna uppsatThis essay intends to investigate and to describe the conditions for recovery of payment of a debt according to chapter 4 § 10 KonkL and to highlight how the regulation is usually interpreted and applied. The purpose is to explain the meaning of the provision's requisites, with an in-depth look at what is meant by ordinary payment and how it is assessed whether a payment is to be regarded as o
Energi och klimatpåverkan är ständigt aktuellt i dagens samhälle. För att motverka den globala uppvärmningen har EU tagit fram klimatmål där bland annat energianvändningen ska minska med 20 % mot 1990 års nivåer år 2020. En stor andel av energianvändningen orsakas i Sverige idag av bygg- och fastighetsbranschen där byggnadsbeståndet står för ca 30 % av energianvändningen. För att klara EU:s klimEnergy use and climate impact are important topics in today’s society. To combat global warming, the EU has set a goal framework with a 20 % reduction target until 2020 for domestic energy use compared to 1990. Today, the building sector in Sweden accounts for 30 % of the domestic energy use. To achieve the goals for energy and climate set by the EU, changes are required. The Swedish parliament ha
I EU-domstolens dom i FCE Bank menade EU-domtolen att ett tillhandahållande av en tjänst mellan ett huvudkontor och dess filial inte utgör en beskattningsbar transaktion då huvudkontoret och dess branch, tillsammans, utgör en och samma beskattningsbara person.Tio år senare dömde EU-domstolen i Skandia America där EU-domstolen menade att den princip som härrör från domen i FCE Bank inte är tillämplIn its ruling in FCE Bank, the CJEU stated that a supply between a head office and its branch does not constitute a taxable transaction since the head office, together with its branch, constitute one taxable person. Ten years later the CJEU ruled in Skandia America stating that the principle deriving from FCE Bank is not applicable when the branch is a member of a VAT group. This ruling generated
Purpose: To investigate the relationship between heart failure (HF) and chronic kidney disease (CKD) by analysing the prevalence of different stages of CKD and other morbidities in patients admitted with acute heart failure (AHF), as well as readmissions and mortality.Introduction: Chronic kidney disease (CKD) is more prevalent among all phenotypes of HF patients than in the general population. It
Because corporations trade on the international markets and the governments regulate on domestic markets, conflicts between government regulations are difficult to avoid. Several authors have introduced different ways to avoid this type of conflict. One alternative, which is also proposed by the EU Commissioner Monti, is the inclusion of minimum regulation in the World Trade Organization, by which
When a child's parents are divorced or separated and violence has occurred between them, several problems can arise in custody cases. The purpose of this thesis is to study these problems and the possibilities to solve them. The first problem I study in this thesis is the different parties' rights which often rise in opposition to one other. These rights refers to the abused parent's r
