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Screening of 29 strains of Neisseria gonorrhoeae revealed that 16/21 serum resistant strains and 0/8 serum sensitive strains bound C4bp. suggesting that C4bp binding to gonococci could contribute to serum resistance. C4bp bound to gonococci retained cofactor (C4b-degrading) function. Using allelic exchange to construct strains with hybrid Por1A/B molecules, we demonstrate that the N-terminal loop
Fondaparinux is a new anticoagulant that interacts with antithrombin III and activated coagulation factor X resulting in an inhibition of the coagulation system. It has been successful in doses of 2.5 mg for thromboprophylaxis as well as in higher therapeutic doses of 5-7.5 mg. No optimal method for monitoring the effects of fondaparinux has been proposed. The aim of the present study was to inves
A simple method is tested for scaling climate-extreme results from high resolution regional climate models (RCMs) to time-periods and emission scenarios for which the RCMs have not been run. The 30 yr mean relationships between indicators of extremes (IoEs) and annual mean daily maximum temperature (T-xa) are investigated. Such relationships from the UK Met Office Hadley Centre RCM HadRM3P, along
Objective: An association between small for gestational age (SGA) and risk for celiac disease (CD) in childhood has previously been reported. However, this association may reflect residual confounding by genetic or environmental factors. For example, presence of subclinical CD in the mother might be a common cause of both SGA and CD in the offspring. We investigate whether SGA is causally associat
The use of baseline lung function in the prediction of chronic obstructive pulmonary disease (COPD) hospitalisations, all-cause mortality and lung function decline was assessed in the population-based "Men Born in 1914" cohort.Spirometry was assessed at age 55 years in 689 subjects, of whom 392 had spirometry reassessed at age 68 years. The cohort was divided into three groups using fixed ratio (F
Prediction of wound healing and major amputation in patients with diabetic foot ulceration is clinically important to stratify risk and target interventions for limb salvage. No consensus exists as to which measure of peripheral artery disease (PAD) can best predict outcomes. To evaluate the prognostic utility of index PAD measures for the prediction of healing and/ or major amputation among patie
AIMS/HYPOTHESIS: To study the heritability and familiality of type 2 diabetes and related quantitative traits in families from the Botnia Study in Finland. METHODS: Heritability estimates for type 2 diabetes adjusted for sex, age and BMI are provided for different age groups of type 2 diabetes and for 34 clinical and metabolic traits in 5,810 individuals from 942 families using a variance compone
Effects of introducing a carbonyl group into the conjugation system of carotenoids were studied for four naturally occurring carotenoids: peridinin, fucoxanthin, siphonaxanthin and spheroidenone. The conjugated carbonyl group affects energetics and dynamics of all these carotenoids in a similar way, although the magnitude of the changes depends strongly on the carotenoid structure. Firstly, presen
Superporous agarose beads contain two sets of pores, diffusion pores and so-called superpores or flow pores, in which the chromatographic flow can transport substances to the interior of each individual bead [Gustavsson and Larsson, J. Chromatogr. A 734 (1996) 231]. The existence of pore flow may be proven indirectly by the chromatographic performance of beads but it has never been directly demons
The outcome of management of diabetic foot ulcers remains a challenge and there remains continuing uncertainty concerning optimal approaches to management. It is for these reasons that in 2008 and 2012 the International Working Group of the Diabetic Foot (IWGDF) working group on wound healing published systematic reviews of the evidence to inform protocols for routine care and to highlight areas w
Aim. The aim of this study was to investigate the role of two candidate gene polymorphisms for insulin resistance and lipid levels in obese children and adolescents. Methods. Two markers of insulin resistance and lipid levels, Pro12Ala in peroxisome proliferator-activated receptor-gamma2 (PPARG) and G276T in adiponectin (ADIPOQ), were genotyped in 285 obese children and adolescents. As the apolipo
AIM: To find out if ILT can be used as radical treatment of breast cancer. METHOD: Twenty-four patients, aged 39-84 (mean 61), with invasive breast cancer were treated with ILT. All underwent mammography, ultrasound and core biopsy before treatment. The tumour was an invasive ductal carcinoma in 15 patients, a lobular carcinoma in eight and lobular-ductal cancer in one. Average tumour diameter was
Objective: To compare guidelines from the Royal College of Obstetricians and Gynaecologists (RCOG) based on the Risk of Malignancy Index (RMI) with a protocol based on logistic regression model LR2 developed by the International Ovarian Tumour Analysis (IOTA) group for triaging women with an ovarian mass as low, moderate, or high risk of malignancy. Design and setting Observational diagnostic stud
An indoor mating disruption experiment was performed on the stored-product pest Plodia interpunctella. The female of this: species emits a four-component pheromone blend consisting of Z9,E12-14: OAc, Z9,E12-14: OR Z9,E12-14: Ald, and Z9-14: OAc. Mating of Plodia interpunctella was disrupted up to 93% by using synthetic pheromone in small-scale plot experiments. The study was performed in 2.5 m x 2
Objectives: The strategies used to support smoking cessation among quitters were investigated according to year of smoking cessation and sociodemographic characteristics. Methods: The 2004 public health survey in Skane, Sweden, is a cross-sectional study. A total of 27 757 people aged 18-80 answered a postal questionnaire. The participation rate was 59%. Different strategies to support smoking ces
Determination of dissolved L-lactate in tomato paste and baby food samples using a SIRE-based (sensors based on injection of the recognition element) biosensor is reported. The measuring principle is based on the use of a small amount of enzyme, which is injected into an internal delivery flow system and held in direct spatial contact with the amperometric transducer by the use of a semipermeable
Copolymers of N-acryloyl-m-aminophenylboronic acid (NAAPBA) with acryamide (AA), N,N-dimethylacrylamide (DMAA), and N-isopropylacrylamide (NIPAM) were found to adsorb on cross-linked agarose gel (Sepharose CL-6B) in the pH range from 7.5-9.2, due to specific boronate-sugar interactions. The molar percentages of phenylboronic acid (PBA) groups in the boronate-containing copolymers (BCCs), as estima
Synnerligen grov misshandel är en brottstyp som introducerades i svensk straffrätt år 2010, detta efter att regeringen uttryckt att straffskärpningar behövdes då man inte ansåg att de utdömda straffen var proportionerliga i förhållande till brottets allvar. Flertalet fall har sedermera hamnat i HD och hovrätterna och en praxis har skapats kring vad brottet innebär. Stort fokus läggs på hänsynslöshExceptional aggravated assault is a crime which was introduced to Swedish criminal law in 2010. The reason behind this was the fact that the Swedish government believed that harsher punishments were needed due to the fact that they were not proportional in comparison to the seriousness of the crime. Regarding what is to be considered as exceptional aggravated assault, the courts tend to focus on t
Denna uppsats har haft som utgångspunkt att granska och utvärdera SOU 2012:17. SOU 2012:17 är det senaste inlägget i en debatt som pågått väldigt länge. SOU 2012:17 föreslår att det ska återinföras ett tillräknelighetsbegrepp i Sverige för att avgöra vem som ska ses som ansvarig för sina handlingar. Dock är det inte alla förslag i SOU 2012:17 som är ett steg framåt. Vissa av förslagen riskerar ledThe starting point of this essay was to analyze and evaluate SOU 2012:17. Which is the latest addition to a long-running debate. SOU 2012:17 suggests that the clause of accountability should be re-introduced to Swedish law, this to more clearly decide who can be held accountable for their crimes and who cannot. Although, not all of the suggestions put forth in SOU 2012:17 are a step forward. Indee
Solkräm – en miljöfara? Solskyddsprodukter används i allt större utsträckning för att skydda oss mot bland annat hudcancer. Vi informeras ständigt om vikten av att smörja oss med solskydd för att undvika skador på huden. Vad som däremot inte informeras om är att vi samtidigt bidrar till stora utsläpp av kemikalier som kan ge negativa effekter för livet i sjöar och hav. Solvårdsprodukter såldes The aim of the study was to perform a hazard assessment of ingredients in sunscreen products available on the Swedish market. Data was collected by documentation of all ingredients in 110 frequently occurring sunscreen products from 15 different brands and by a screening of four known databases for collection of hazard classifications of the ingredients. The study shows that 96 out of 347 ingredie
