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Bradykinin receptors have been identified in human gingival fibroblasts; the primary signal transduction pathways and their dependence on calcium have been characterized. Binding data revealed a calcium-independent binding of bradykinin to the cell membrane with a receptor density of 25,000 receptors per cell and a K d
Secondary AML (s-AML), including AML with an antecedent hematologic disorder (AHD-AML) and therapy-related AML (t-AML), constitutes a large proportion of patients with AML and is considered to confer a dismal prognosis. The role of allogeneic hematopoietic cell transplantation (HCT) in patients with s-AML and the extent to which HCT is performed in these patients has been little studied to date. W
PURPOSE: Nucleophosmin 1 (NPM1) mutations are associated with a favorable prognosis in acute myeloid leukemia (AML) when an internal tandem duplication (ITD) in the fms-related tyrosine kinase 3 gene (FLT3) is absent (FLT3-ITDneg) or present with a low allelic ratio (FLT3-ITDlow). The 2017 European LeukemiaNet guidelines assume this is true regardless of accompanying cytogenetic abnormalities. We
Introduction: Pancreatic cancer is a highly lethal disease with a close association between incidence and mortality. First-line (FL) palliative chemotherapy prolongs survival and alleviates cancer-related symptoms. However, the survival benefit of second-line (SL) treatment is uncertain, as studies fail to consistently show prolonged survival for any given SL treatment, and in the absence of progn
BACKGROUND: Clinical outcome of patients with triple-negative breast cancer (TNBC) is highly variable. This study aims to identify and validate a prognostic protein signature for TNBC patients to reduce unnecessary adjuvant systemic therapy.METHODS: Frozen primary tumors were collected from 126 lymph node-negative and adjuvant therapy-naive TNBC patients. These samples were used for global proteom
Background: Insulin-like peptide 3 (INSL3) is a constitutive hormone secreted in men by the mature Leydig cells of the testes. It is an accurate biomarker for Leydig cell functional capacity, reflecting their total cell number and differentiation status. Objectives: To determine the ability of INSL3 to predict hypogonadism and age-related morbidity using the EMAS cohort of older community-dwelling
Johannes Magnus (1488–1544) was the last Catholic archbishop of Uppsala to hold residence in Sweden. He was also a historian and wrote a work in Latin about Swedish history that was to gain an unparalleled importance. The work is entitled Historia de omnibus Gothorum Sueonumque regibus, the ‘History of all the Kings of the Goths and the Swedes’. It is arranged as a series of biographies of over 20
If we are being-of-the-world, how can we ever avoid participation? From this question Avhandling / Av_handling (Dissertation / Through_ action) unfolds. It invites to engage in an ongoing continuum of entanglements, where the moment of connection is unavoidable. This invitation demands that we are attentive to our mutual co-constitutiveness, that we take responsibility for what gets excluded as we
In the present work, the possibility of using photofragmentation laser-induced fluorescence (PFLIF) for thermometry in different reacting flows is investigated. Hydroxyl (OH) fragments are created by UV-laser (266nm) fragmentation of hydrogen peroxides (H2O2 and HO2), whereupon the fluorescence, induced while scanning the wavelength of a second laser across the A2σ+(v = 1)-X2Π(v = 0) absorption ba
This article examines the pathophysiology of lesions caused by focal cerebral ischemia. Ischemia due to middle cerebral artery occlusion encompasses a densely ischemic focus and a less densely ischemic penumbral zone. Cells in the focus are usually doomed unless reperfusion is quickly instituted. In contrast, although the penumbra contains cells "at risk," these may remain viable for at least 4 to
BACKGROUND: Of all patients with low back pain, 85% are diagnosed as "non-specific lumbar pain". Lumbar instability has been described as one specific diagnosis which several authors have described as delayed muscular responses, impaired postural control as well as impaired muscular coordination among these patients. This has mostly been measured and evaluated in a laboratory setting. There are fe
Purpose Gangliogliomas are highly epileptogenic tumors that are common in epilepsy surgery. The main aim of this study was to investigate whether the outcome of Anti-seizure medication (ASM) withdrawal differed between patients undergoing ganglioglioma surgery in an epilepsy surgery program compared with those who underwent surgery in other surgical programs. We also investigated which factors inf
Wild bees foraging in contemporary agricultural landscapes are, because of agricultural intensification, faced with the challenges of reduced flower-rich habitats, as well as a changed spatio-temporal distribution of flower resources. As a result of this and other stressors such as pesticide exposure, widespread declines of bees have been reported. However, all bees are not equally affected. To be
Popular Abstract in Swedish Polymergeler och deras interaktioner med joniska surfaktanter. Olika typer av hydrofoba polymerer och hydrophobmodifierade polymerer tvärbinds kemisk till geler. Dessa geler tillhör gruppen responsiva geler, vilket betyder att gelerna ändrar sin volym under yttre påverkan. Gelernas volymändring studeras vid tillsats av olika joniska surfaktanter, vid tillsats av saltThe response on chemically crosslinked gels and polymer solutions on the addition of ionic surfactants and/or addition of salt at different temperatures have been studied. All polymers studied are water soluble and slightly hydrophobic or hydrophobically modified. Because of their hydrophobicity the polymers have a strong tendency to associate, both with themselves and with surfactants. Another i
A systematic study of cell membrane morphologies whose structure is governed by cubic symmetries has been performed. It is suggested that they are described by periodic cubic surfaces for which space filling surface foliations given by truncated Fourier series defined by the space groups is used as structural representations. Using this a method is developed which enables a direct ultrastructural
Liberalisation and deregulation of public utility sectors has been introduced in several European countries. In 1994 Swedish municipalities were instructed to reorganise waste collection routines by enlarging the number of fractions to be able to reuse waste fractions in an environmental benign way. The public waste sector have to a considerable extent been diversified and deregulated. At the same
As smart and as stupid, as well- and ill-informed, as curious and closed-minded as any random sample, tourists represent a unique object of study, as they are “the last remaining class that exhibits consciousness for itself” (MacCannell, 2013 p.xix). Technology has been transforming the tourist experience deeply, as it both fulfils a functional purpose of performing tasks for humans, and it holds
Insect herbivory is one of the most important ecological processes affecting plant–soil feedbacks and overall forest ecosystem health. In this study, we assess how elevated carbon dioxide (eCO2) impacts (i) leaf level insect herbivory and (ii) the stand-level herbivore-mediated transfer of carbon (C) and nitrogen (N) from the canopy to the ground in a natural mature oak temperate forest community
Denna uppsats behandlar regleringen rörande hyper- och inlinelänkar till upphovsrättsskyddat material på internet. Uppsatsen analyserar även potentiella samhällsekonomiska konsekvenser av regleringen ur ett rättsekonomiskt perspektiv. Länkar fungerar som ett verktyg för att underlätta navigering på internet. Upphovsrätten skyddar den som skapat ett litterärt eller konstnärligt verk. I Sverige reglThis essay deals with the regulation regarding inline- and hyperlinks to copyright protected material on the Internet. The essay also analyses the potential consequences of the regulation with an economic analysis of law. Links serve as a tool to navigate on the Internet. Copyright protects the author of a literary or artistic work. In Sweden this right is governed by URL. This law has been adapte
Godssektorn spås bli en tidig användare av självkörande fordonsteknik. Minskade drivmedelskostnader, ökad flexibilitet i ruttplaneringen och utökade drifttider är exempel på incitament för godsföretag att ställa om till en självkörande lastbilsflotta. Automatiseringen kommer mest sannolikt ske gradvis. I tidiga skeden spås självkörande lastbilar (AT:s) ha en konservativ körstil där körfältsbyten uThe truck sector is thought to be one of the first adopters of autonomous driving technology. Reduced fuel- and labour costs, increased flexibility in scheduling and increased hours of service, are all incentives for the freight companies to go autonomous. The automation of the truck fleet is likely to be gradual. At first, autonomous trucks (AT:s) are expected to have a conservative driving style
