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The only validated method to characterize the phenotype and to reach a definitive diagnosis of Malignant Hyperthermia Susceptibility (MHS; OMIM *145600), a pharmacogenetic disease linked to the Ryanodine 1 receptor gene (RYR1; OMIM *180901), is an invasive muscle contraction test requiring a muscle biopsy, according to the European (IVCT) protocol or to the North American (CHCT) protocol. The seri
Abstract: Balanced microbiota of the gastrointestinal (GI) tract is important for maintaining health of the host. Altered gut microbiota have been found to be associated with various life-style induced and other intestinal inflammatory diseases. Gut microbiota is viewed as a metabolic organ and considered as new target for therapies. This thesis describes the work on exploring the microbiota of th
Popular Abstract in Swedish Min avhandling heter Knowledge and Survival in the Novels of Thomas Hardy (disputationsdag: 15 april 2000). Jag fokuserar på två sorters vetande: det traditionella, som jag kallar ‘det vardagliga’, och ‘det specialiserade’, som är knutet till modern vetenskaplig utveckling.Abstract This thesis identifies two different kinds of knowledge in Thomas Hardy's novels: the everyday, passed on from generation to generation, which is non-academic and closely bound to the local environment and its traditions; and the specialised, recorded in the printed word, which is the product of formal education and independent of the local community and its traditions. These two kinds o
Popular Abstract in English Plants harvest sunlight to fix air carbon dioxide into a form which is the fundamental source of energy for other organisms such as animals. The domestication of crop plants and traditional breeding practices has resulted in increased yield and nutritional value of crops. This comes at a cost of loss in genetic variability that is required by living organisms to adapt tPotato is one of the major food crops and its yield is severely affected by late blight disease caused by Phytophthora infestans. P. infestans has the ability to manipulate plant defence signalling by secreting effector molecules causing so called effector triggered susceptibility. Some plants can recognize these effectors via resistance proteins that reactivate plant defence and lead to effector
Studying gene-lifestyle interaction may help to identify lifestyle factors that modify genetic susceptibility and uncover genetic loci exerting important subgroup effects. Adequately powered studies with prospective, unbiased, standardised assessment of key behavioural factors for gene-lifestyle studies are lacking. This case-cohort study aims to investigate how genetic and potentially modifiable
Xylanases without contaminating cellulases are produced by a wide variety of aerobic bacteria and fungi but anaerobic organisms producing such enzymes are rare. Clostridial species viz., Clostridium beijerinckii LU-1, C. acetobutylicum LU-1, C. butyricum and C. bifermentans LU-1 isolated from rumen produced xylanase (E.C. 3.2.1.8) of 1.5-4.2 U/ml on oat spelt xylan as sole carbon source. Cellulose
Uppsatsens syfte är att undersöka hur och varför lagstiftningen kring påföljden livstidsstraff vid mord har förändrats under de senaste 15 åren, 1999-2014, i Sverige samt de bakomliggande tankegångarna. Uppsatsen presenteras ur ett rättshistoriskt perspektiv. För att kunna ge en bättre bakgrund har en kort historisk bakgrund presenterats som sedan övergår i uppsatsens avhandling gällande de senaThe purpose of this essay is to investigate how and why the legislation concerning the sentence of life imprisonment for murder has changed in Sweden over the past 15 years, 1999-2014, and the thought process behind the changes. The investigation will be presented from a legal historical perspective. In order to explain the development a short historical background has presented the thoughts behi
In 1994 the Swedish Construction Code, BKR, was changed from being based on material to being based on function. This permitted constructing multi-storey buildings with a bearing framework made of wood, which had been prohibited since the end of the 19th century. There is now a growing in- terest of using wood as a construction material. In Växjö four seven-storey buildings, Limnologen, are under
Mellan cirka 30-50 procent av den mat som produceras i världen årligen kommer aldrig människan tillgodo som föda. Att mat slängs eller på annat sätt går förlorad i livsmedelskedjan är ett stort problem, framför allt för att många människor i världen inte har tillgång till mat men också för att produktionen av livsmedel medför en betydande miljöpåverkan. Vad gäller statistiken över matsvinnet är de
Från och med den 1 januari 2020 skärptes straffskalan för sexköp av barn. Syftet med åtgärden var att förstärka det straffrättsliga skyddet för ungdomar mot att dras in i prostitution. Brottet är förknippat med låg åtalsfrekvens. Det har tidigare förklarats med att aktsamhetskravet i förhållande till ålder i 6 kap. 13 § BrB - som täcker flera sexualbrott med åldersgräns - var särskilt svårt att upIn January 2020 the range of punishment for exploitation of a child through the purchase of a sexual act got stricter. The reasoning behind the change was to strengthen the criminal justice protection for these children. Exploitation of a child through the purchase of a sexual act is associated with a low prosecution frequency. An explanation for this has been that the rule of negligence in the si
PURPOSE The purpose of this study is to examine the effects of coworking space as it relates to meeting the common goals of collaboration, community, and creativity for its members. Through a case study of a coworking space, the study seeks answers to questions as: “How can coworking spaces enhance community, collaboration, and creativity to create a better experience for their members?” and “Are
This master thesis contributed to a project financed by the Swedish Energy Agency and managed by the housing company Eksta AB in collaboration with the consulting Company WSP. The main aim of this master thesis was to perform a theoretical optimization on the usage of own used solar electricity by transferring the surplus PV between buildings in a demonstration area in a DC-microgrid. To achieve th
Increasing demand for metals might lead to extraction of metals from materials, previously, thought of as waste. A letter by the Swedish Environmental Protection Agency and Geological Survey of Sweden from 2017 encouraged new and innovative waste treatments as well as recycling of waste produced in association with mining. The conventional treatment of acid mine wastewater creates large volumes of
INTRODUCTION In the last years a lot of researches about source separation have been realized, like extraction of a signal of interest (vocal recognition application), identification of which source gives which sound (motor engine applications) or noise source characterization (environmental application). Most of these techniques for sound source estimation use the signal-subspace approach, where
Clinical trials of pharmaceuticals have been running in Russia for more than ten years and while it is an attractive location for research, it remains a largely untapped resource as researchers look to expand patient recruitment outside the Western world. While academic sites like Moscow, St Petersburg and Novosibirsk have all gained experience in clinical trials, smaller hospitals in peripheral
Principen om barnets bästa ska vara avgörande i alla frågor som rör vårdnad, boende och umgänge. Den bärande principen återfinns i både FN:s barnkonvention och i föräldrabalken. Principen ska fungera som en rättslig vägledning vid alla utredningar i mål som rör barn, men det finns ingen universellt fastslagen definition av vad som faktiskt är barnets bästa. Utgångspunkterna är att bedöma barnets b
Examensarbetets titel: Shared service center inom revisionsbranchen Seminariedatum: 30 maj, 2024 Ämne/kurs: FEKH69 Examensarbete i redovisning på kandidatnivå, 15 högskolepoäng Författare: Olivia Elldalen, Julius Landin, Linnea Mårtensson Handledare: Alexander Hedlund Fem nyckelord: Shared service center, delivery center, revisor, tillit, revisionsbyrå Forskningsfrågor: Hur och varför använde
I takt med utbyggnaden av vindkraft har artskydd av fåglar blivit en ofta förekommande fråga i tillståndsprövningarna. I dessa förefaller 4 § artskyddsförordningen medföra tolknings- och tillämpningsproblem. Enligt dess ordalydelse ska bestämmelsen nämligen tillämpas på alla vilda fåglar, oavsett art, samt på vissa djurarter. Bestämmelsen föreskriver bland annat förbud mot att avsiktligt döda och In line with the expansion of wind power projects species protection of birds has become a frequent issue in permit procedures. In this context section 4 of the Species Protection Ordinance (2007:845) appears to result in difficulties when interpreted and applied. According to the provision, it should apply to all wild birds, regardless species, and some animal species. The provision stipulates, i
Environmental problems are a discussed subject in the world. The reason for this is that natural disasters are becoming more and more visible. EU is working to reduce the Union's contribution to the greenhouse effect. The goal is to reduce greenhouse gases with 20% by 2020 and 20% of the energy used should come from renewable energy sources. The EU’s Energy Performance of Building Directive (E
