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BACKGROUND: The cross-sectional association between cerebral tissue oxygen saturation (SctO 2) and heart failure (HF) has been previously studied, but the prognostic significance of SctO 2 in HF remains uncertain. This study aimed to assess the role of SctO 2 as a risk factor for all-cause mortality and rehospitalisation, as well as to explore the cross-sectional association between physical activ

Background: Standardised language tests provide a reliable framework for assessing language deficits in individuals with aphasia, but have long been lacking for various languages, including Swedish. The purpose of this study was to examine the diagnostic accuracy and establish the norm-references of the Swedish version of the Comprehensive Aphasia Test (CAT-S). Methods: Consecutive patients with a

Susceptibility testing of clinical multidrug-resistant (MDR) and reference P. aeruginosa strains was performed using the standard twofold serial dilution method. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of antiseptics were determined. MIC and MBC values were also interpreted as the bacteriostatic index of antiseptic activity (BSIAA) and the bactericid

The Arctic is warming at twice the global average speed, and the warming-induced increases in biogenic volatile organic compounds (BVOCs) emissions from Arctic plants are expected to be drastic. The current global models' estimations of minimal BVOC emissions from the Arctic are based on very few observations and have been challenged increasingly by field data. This study applied a dynamic ecosyst

Background: Chronic Pseudomonas aeruginosa (PA) infection causes increased morbidity and mortality in cystic fibrosis (CF). This study aimed to answer the following questions: Does the prevalence of chronic infection with PA differ between the CF centres in Scandinavia? Which differences exist concerning segregation and treatment of PA? Methods: 989 patients (86%) from all eight CF-centres in Scan

Laser Doppler velocimetry (LDV) measurement and large eddy simulation (LES) were used to study confined isothermal turbulent swirling flows in a model dump combustor. The aim was to gain deeper understanding of the flow and turbulence structures in dump combustors and to examine the capability of LES for prediction of turbulent swirling flows. A refractive index matching technique is used in the L

Proteins are large, complex molecules that play many critical roles in the body and are required for the structure, function, and regulation of the body’s tissues and organs. In very simple terms, a protein can be defined as a linear chain of subunits called amino acid residues. The individual amino acid residues are sequentially bonded together by peptide bonds. There are 20 standard amino acids This work is primarily about the development, validation and application of computer simulation models for intrinsically disordered proteins, both in solution and in the presence of uniformly charged, ideal surfaces. The models in question are either coarse-grained or atomistic in nature, and their applications are dependent on the specific purpose of each study. Both, Metropolis Monte Carlo and m

Background/Aim: Signs of hypoxic ischaemic encephalopathy (HIE) on head computed tomography (CT) predicts poor neurological outcome after cardiac arrest. We explore whether levels of brain injury markers in blood could predict the likelihood of HIE on CT. Methods: Retrospective analysis of CT performed at 24–168 h post cardiac arrest on clinical indication within the Target Temperature Management

Background: Influenza vaccination early after myocardial infarction (MI) improves prognosis but vaccine effectiveness may differ dependent on type of MI. Methods: A total of 2,571 participants were prospectively enrolled in the Influenza vaccination after myocardial infarction (IAMI) trial and randomly assigned to receive in-hospital inactivated influenza vaccine or saline placebo. The trial was c

The demand for energy in the world is increasing steadily. As the standard of living for people in the developing countries is increasing so is the net energy use per capita. The main contributor to the energy consumption is the use of fossil fuels, which is also the major emission source for carbon dioxide. Carbon dioxide is in turn one of the most significant greenhouse gases and will enhance te

GLPG1972/S201086 is a disintegrin and metalloproteinase with thrombospondin motif-5 (ADAMTS-5) inhibitor in development as an osteoarthritis disease-modifying therapy. We report the safety, tolerability, pharmacokinetics, and pharmacodynamics (turnover of plasma/serum ARGS-aggrecan neoepitope fragments [ARGS]) of GLPG1972 in 3 randomized, double-blind, placebo-controlled phase 1 trials. Study A, a

Gestational diabetes mellitus(GDM) defines an unhealthy state of hyperglycaemia that develops in response to an otherwise normal physiological adaptive insulin resistance state during pregnancy. However, the exact plasma glucose levels differentiating the unhealthy GDM state from a normal pregnancy is unknown, and relies upon arbitrary cut off criteria based on associations with adverse health out

Background Abdominal symptoms are diagnostically challenging to general practitioners (GPs): although common, they may indicate cancer. In a prospective cohort of patients, we examined abdominal symptom frequency, initial diagnostic suspicion, and actions of GPs in response to abdominal symptoms. Methods Over a 10-day period, 493 GPs in Norway, Denmark, Sweden, Belgium, the Netherlands, and Scotla

After the General Court’s (GC) decision in case T-472/13 H. Lundbeck A/S and Lundbeck Ltd v Commission it seems the concept of potential competition in the context of so-called ‘pay-for-delay’ agreements, or reverse patent settlements, might have been altered; that the bar in order for an undertaking to qualify as a potential competitor might have been lowered. This thesis aims to examine whether

Everyday items release of nanoplastics A well-known problem of today’s society is the large plastic pollutions on both land and in the oceans. The macroplastics (5mm to 20 μm) and the microplastics (smaller than 5 mm.) are well studied, and it is generally known that these types of particles are harmful for animals if ingested or entangled. Even though it is generally thought that plastics only d

Datorsimuleringar blir ett allt viktigare verktyg för att förstå, utveckla och effektivisera alla sorters processer och produkter i vårt samhälle. Det är ofta svårt att exakt efterlikna verkligheten, och för att göra simuleringarna möjliga används ofta modeller som förenklar verkligheten.In this master thesis computational fluid dynamic simulations of two plate heat exchanger channels have been performed in Ansys CFX. The full geometry of the channels has not been included, the channels were modeled with a flat geometry instead of a corrugated pattern. To account for the effect of the corrugation on the pressure drop, one-time pressure losses and momentum sources were added in the

The phenomenon of global warming has become a fact, however; the uncertainty is about the magnitude and acceleration of its manifestations. Global mean sea level rise is one of the results induced by global warming and is happening with an undetectable accelerated pace. The world international organizations and governments are devoting efforts and initiatives in a trial to manage global warming in

Popular Abstract in Swedish Avhandlingen omfattar fyra artiklar inom empirisk finansiell ekonomi. Det första kapitlet är en kort sammanfattning av avhandlingens innehåll. Det andra kapitlet, Dynamic Portfolio Selection: The Relevance of Switching Regimes and Investment Horizon. (samförfattad med Birger Nilsson) undersöker dynamiskt portföljval och efterfrågan på tidsdiversifiering då aktieavkastnThis thesis consists of four empirical studies on financial economics. The first chapter contains a short summary of the thesis. The second chapter Dynamic Portfolio Selection: The Relevance of Switching Regimes and Investment Horizon (co-authored with Birger Nilsson) investigates the questions of dynamic portfolio selection and intertemporal hedging within a Markovian regime-switching framework.

The quantitative relationship between exposure to physical risk factors and upper extremity work-related musculoskeletal disorders (UE-WMSDs) is virtually unknown. To explore the variation, objective measurements were derived in 43 types of work (686 individuals), using goniometry for the wrists and electromyography (EMG) for the forearm extensor muscles. The variations due to work were great for

Syftet med uppsatsen är att undersöka hur familjevåld påverkar bedömningen av barnets bästa i frågor om vårdnad, boende och umgänge. Med våld avses våld riktat mot någon annan i familjen än barnet. Jag har använt mig av tre frågeställningar för att lyfta fram vilken betydelse våldet har för barnet. Den första frågeställningen är mer övergripande och handlar om hur våldet påverkar barnets bästa. DeThe aim of this thesis is to examine how domestic violence affects the decision of what is in the best interest of the child with regards to parental authority judgments. In this thesis the term domestic violence refers to all violence towards another family member except the child himself. The thesis is built upon three questions in order to highlight the impact domestic violence has upon the dec