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The molecular self-diffusion coefficients were accessed, for the first time, in solutions of microcrystalline cellulose, dissolved in 30 wt% and 55 wt% aqueous tetrabutylammonium hydroxide, TBAH (aq), and in mixtures of 40 wt% TBAH (aq) with an organic co-solvent, dimethylsulfoxide (DMSO), through pulsed field gradient stimulated echo NMR measurements. A two-state model was applied to estimate α (
There is a need for consensus on the recommendations for follow-up of children and adolescents with celiac disease. Objectives: To gather the current evidence and to offer recommendations for follow-up and management. Methods: The Special Interest Group on Celiac Diseases of the European Society of Paediatric Gastroenterology Hepatology and Nutrition formulated ten questions considered to be essen
The Memorial Sloan Kettering Cancer Center (MSKCC) recommendations on prostate cancer screening were developed in response to three limitations of previous screening guidelines: insufficient evidence base, failure to link screening with treatment, and lack of risk stratification. The objective of the recommendations is to provide a schema for prostate cancer screening that maximizes the benefits,
Objective: Asthma is divided into various distinct phenotypes on the basis of clinical characteristics, physiological findings, and triggers, and phenotyping is usually performed in a hypothesis-driven univariate manner. However, phenotyping can also be performed using computer algorithms to evaluate hypotheses-free relationships among many clinical and biological characteristics. We aimed to iden
Purpose/Objective(s): Over 30% of advanced prostate cancers harbor a predominance of neuroendocrine prostate cancer (NEPC) differentiation. Fluorodeoxyglucose (FDG) positron emission tomography (PET) has numerous limitations in prostate adenocarcinoma (PCa-adeno), however there is no data that exists outside of isolated single person case reports to assess the utility of PET to restage and monitor
The impact of climate change on global biodiversity is firmly established, but the differential effect of climate change on populations within the same species is rarely considered. In ectotherms, melanism (i.e. darker integument due to heavier deposition of melanin) can significantly influence thermoregulation, as dark individuals generally heat more and faster than bright ones. Therefore, darker
Aim: Bridge to surgery (BtS) aims to decrease perioperative morbidity and mortality in emergency resection (ER) of the colon. Previous results are inconsistent, and long-term comparisons are scarce. The aim of this study was to compare the short- and long-term outcomes of BtS and ER. Method: This retrospective study examined data from the Swedish Colorectal Cancer Registry for patients treated for
In septic shock, administration of large fluid volumes is associated with poor outcomes. Recent evidence shows that non-resuscitation fluids are the major modifiable source of fluids for patients with septic shock in intensive care units (ICUs). This clinical trial is designed to test the hypothesis that restrictive administration of non-resuscitation fluids improves outcomes compared to usual car
We introduce a novel unsteady shear protocol, which we name rotary shear (RS), where the flow and vorticity directions are continuously rotated around the velocity-gradient direction by imposing two out-of-phase oscillatory shears (OSs) in orthogonal directions. We perform numerical simulations of dense suspensions of rigid non-Brownian spherical particles at volume fractions between 0.40 and 0.55
Background: It is unclear whether thyroid hormone levels are associated with the risk of mortality, cardiovascular disease (CVD) events, or cancer in men with normal TSH. Objectives: We analyzed if serum free T4 (FT4) or TSH is associated with the risk of mortality, incident CVD events, or cancer in Swedish men. Methods: Elderly men (n = 1801; mean age 75 years) in the Gothenburg and Malmö subcoho
Aims: Individuals with type 1 diabetes (T1D) are typically diagnosed at a young age and exposed to lifelong hyperglycaemia. Despite improved metabolic control, the risk of vascular complications remains challenging. However, some individuals remain free from developing major diabetic complications even after long duration, so-called “escapers”. This study investigated transcriptomic biomarkers lin
Aim: To evaluate the impact of initial mono- versus multitherapy on the ocular surface and related quality of life after 5 years follow-up in the Glaucoma Intensive Treatment Study (GITS). Method: The study included patients with primary open-angle glaucoma and pseudoexfoliation glaucoma who completed 5-year follow-up in GITS. Assessment of ocular surface disease (OSD) symptoms was done using a Sw
Many studies identify energy efficiency as the most important and least costly option for reducing CO2-emissions while at the same time contributing to other policy objectives. The main challenge seems to be how to design, implement and evaluate policy to ensure that these opportunities are captured and policy perceived as legitimate. There is often a gap between rhetoric or broadly stated objecti
Purpose — We wanted to examine the potential of the Scandinavian Sarcoma Group (SSG) Central Register, and evaluate referral and treatment practice for soft-tissue sarcomas in the extremities and trunk wall (STS) in the Nordic countries. Background — Based on incidence rates from the literature, 8,150 (7,000–9,300) cases of STS of the extremity and trunk wall should have been diagnosed in Norway,
Thin, free films based on Kollicoat SR:Eudragit NE blends were prepared by casting or spraying aqueous dispersions of these polymers, and were thoroughly characterized with respect to their water uptake behavior, water permeability, dry mass loss kinetics, mechanical properties and drug release patterns. A mechanistic mathematical model based on Fick's law of diffusion was used to quantify the exp
The anticonvulsive effect of lidocaine was evaluated in 46 newborn infants with severe, recurrent seizures. Before the lidocaine all infants were being given phenobarbital, and 22 infants were also treated with diazepam. Different dosages of lidocaine were tested. A loading dose of 2 mg/kg followed by i.v. infusion of 6 mg/kg/hour was the most effective dosage and had an immediate anticonvulsive e
Moisture and ionic transport under non-saturated condition is an important, but poorly understood transport phenomena particularly for mature systems containing supplementary cementitious materials. This paper investigates the moisture and chloride profiles of 3-year old mortars containing Portland cement (OPC), slag and silica fume (SF) after long-term (30–48 months) wick action exposure in 1.09
