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Efficient and timely maintenance is essential for the robust operation of infrastructure across all types of transport. In the railway sector, track maintenance presents unique challenges. Specifically, some maintenance tasks require track closures, which can disrupt train schedules. Coordinating these closures with regular train operations makes the scheduling process complicated. To ensure suffi
To further clarify the mechanisms maintaining chronic atrial fibrillation (CAF), a method identifying preferable activation patterns of the atria during fibrillation, by time averaging of multiple discrete excitation vectors, was developed. Repeated recordings, each of 56 atrial bipolar electrograms simultaneously acquired during 8 s, were made at multiple sites in the right atrial free wall and t
This thesis focuses on processing and electro-optical investigations of two- and three-terminal photodetectors based on large arrays of around three million n+-i-n+ InP nanowires with embedded InAsP quantum heterostructures for broadband detection. First, we investigated the optoelectronic behavior of two-terminal photodetectors under selective 980 nm excitation of the 20 axially embedded InAsP qu
Severe viral pneumonia is a significant cause of morbidity and mortality globally, whether due to outbreaks of endemic viruses, periodic viral epidemics, or the rarer but devastating global viral pandemics. While limited anti-viral therapies exist, there is a paucity of direct therapies to directly attenuate viral pneumonia-induced lung injury, and management therefore remains largely supportive.
Aqueous dispersions of charged-neutral block copolymers (poly(acrylamide)-b-poly(acrylate)) complexed with an oppositely charged surfactant (dodecyltrimethylammonium) have been prepared by different approaches: the simple mixing of two solutions (MS approach) containing the block copolymer and surfactant, with their respective simple counterions, and dispersion of a freeze-dried complex salt prepa
SCOPE: Evidence suggests a positive association between ultra-processed food (UPF) consumption and the incidence of cardiovascular disease (CVD). We aimed to investigate associations between UPF intake and respiratory disease, CVD, and their multimorbidity in a large prospective cohort.METHODS AND RESULTS: Within the UK Biobank, participants who were free from respiratory disease or CVD at baselin
After World War II and prior to the financial deregulation of the 1980s, monetary policy in Sweden as well as in other western European countries rested chiefly on a system of far- reaching non-market-oriented controls of credit flows and interest rates. How was monetary policy conducted in such an environment of financial repression, where the central bank was unable to rely on traditional moneta
The double nucleation mechanism of amyloid β (Aβ) peptide aggregation is retained from buffer to cerebrospinal fluid (CSF) but with reduced rate of all microscopic processes. Here, we used a bottom-up approach to identify retarding factors in CSF. We investigated the Aβ42 fibril formation as a function of time in the absence and presence of apolipoprotein A-I (ApoA-I), recombinant high-density lip
Background: Apnea of prematurity is a common problem in preterm infants that may have significant consequences on their development. Methylxanthines (aminophylline, theophylline, and caffeine) are effective in the treatment of apnea of prematurity. Doxapram is used as a respiratory stimulant in cases refractory to the methylxanthine treatment. Objectives: To evaluate the benefits and harms of doxa
The normal-like molecular subtype of breast cancer has not been well characterized and is currently not included in the clinically approved PAM50 molecular subtype classification. Tumors classified as normallike display high expression of basal epithelial genes and low expression of luminal epithelial genes, but also high expression of genes expressed by non-epithelial cell types including adipocy
A data-driven method combined with the formulations of boundary integral equations is developed for the frequency-domain analysis of parametrized acoustic systems, arising from the spatial discretization of the linear Helmholtz equation. The method derives surrogate models for the approximation of frequency response functions at selected field points via the construction of neural networks with ra
Power consumption has become a leading concern for SoC aimed at 5G products that demand increased functionality, smaller form factors, and low energy footprint. For some EMCA IP blocks a hierarchical clock gating mechanism ensures coarse-grained power savings based on actual processing need but for many blocks this approach cannot be employed. This implies that these blocks have to rely on a high
Electricity differs from other commodities in that it cannot be stored. This non-storability characteristic results in traditional pricing methods for commodities not being applicable for electricity. An alternative pricing method is therefore needed and the solution is the Hourly Price Forward Curve (HPFC). The HPFC essentially gives the prices as of today for the delivery of electricity at each
Physics-informed neural networks integrate physical laws into machine learning models to solve differential equations. This thesis investigates an inverse physics-informed neural network framework for estimating viscosity in Tetra Pak’s injection molding process, where direct measurements are not possible. By enforcing the Navier-Stokes equations and using sparse velocity and pressure data, a virt
As awareness of the environmental and health issues associated with PFAS materials production, the EU has encouraged industries to search for alternatives to traditional PTFE coatings. This thesis, conducted in collaboration with Tetra Pak as a part of PFAS free project, investigates surface engineering treatments for stainless steel used in cheese processing equipment. The goal is to identify rep
Cancer is the leading cause of death in the world. Multiple different treatment options are available, target therapy and immunotherapy being two. One potential target is Fibroblast Growth Factor Receptors (FGFRs) and there are both available treatments and new treatments being investigated for this. However, only around 25% of patients benefit from the immunotherapy treatment Immune Checkpoint In
In this study suggested political instruments for a future sustainable transportation system are analyzed. This is done by a survey study with answers from municipality workers in ten different municipalities in the Scania region, southern Sweden. The questions covers the respondents transportation habits and their opinions on 19 different political instruments and how these instruments, if put in
PURPOSE: Reliable molecular diagnostic tools are still unavailable for making informed treatment decisions and monitoring the response in patients with castration resistant prostate cancer. We evaluated the significance of whole blood circulating androgen receptor transcripts of full length (AR-FL) and splice variants (AR-V1, AR-V3 and AR-V7) as biomarkers of abiraterone acetate treatment resistan
Viruses are infections species that infect a large spectrum of living systems. Although displaying a wide variety of shapes and sizes, they are all composed of nucleic acid encapsulated into a protein capsid. After virions enter the host cell, they replicate to produce multiple copies of themselves. They then lyse the host, releasing virions to infect new cells. High proliferation rate of viruses
Lateral gene transfer (LGT) is an important mechanism of evolution for protists adapting to oxygen-poor environments. Specifically, modifications of energy metabolism in anaerobic forms of mitochondria (e.g., hydrogenosomes) are likely to have been associated with gene transfer from prokaryotes. An interesting question is whether the products of transferred genes were directly targeted into the an
