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Leukocyte telomere length (LTL) is related to the aging of somatic cells. We hypothesized that LTL is inversely associated with mortality in elderly men. LTL was measured in 2744 elderly men (mean age 75.5, range 69-81years) included in the prospective population-based MrOS-Sweden study. Mortality data were obtained from national health registers with no loss of follow-up. During the follow-up (me
PURPOSE: We review the current epidemiological and genetic knowledge regarding hereditary prostate cancer, and outline its clinical implications. MATERIALS AND METHODS: Published articles on hereditary prostate cancer were identified using the MEDLINE data base. RESULTS: A risk of prostate cancer, particularly early onset disease, is strongly affected by family history (number of relatives with pr
The association between medical risk factors and the outcome of foot ulcers was evaluated in 208 consecutive diabetic patients with severe peripheral vascular disease (systolic toe blood pressure < or = 45 mm Hg). All patients were treated and followed by the same foot care team. Eighty patients healed primarily, 83 healed after a minor or major amputation, and 45 died. The systolic toe blood pres
To determine the impact of a family history of the common form of type 2 diabetes and the phenotype of the proband on anthropometric and metabolic variables in normoglycemic first degree relatives, we studied 2100 first degree relatives of patients with the common form of type 2 diabetes (FH+) and 388 subjects without a family history of diabetes (FH-). All subjects participated in an oral glucose
Alpha-1-antitrypsin (AAT) is a glycoprotein synthesised in the liver. Its main role is to protect lung tissue from destruction by neutrophil elastase. In severe (PiZZ) AAT deficiency, there is an increased risk of emphysema, especially in smokers. The deficiency is caused by the retention and aggregation by polymerization of the AAT molecules in the liver, which increases the risk of neonatal chol
Popular Abstract in English The main reason that we humans exist at all is because of photosynthesis. The food we eat, the oxygen we breath, most of the energy that warms our homes and powers our electronics are all products of photosynthesis. Over millions of years, plants, algae and some bacteria have developed biomachinery to harness solar energy and thrive. They do this by fixing carbon into cAlmost all life on Earth depends on the products of photosynthesis — the biochemical process whereby solar energy is stored as chemical-rich compounds. The energy of captured photons is transferred through a network of pigment-protein complexes towards the reaction center. The reaction center is responsible for trans-membrane charge separation, which generates a proton motive force which drives al
Object. With increasing use of endovascular procedures, the number of aneurysms treated surgically will decline. in this study the authors review complications related to the surgical treatment of aneurysms and address the issue of maintaining quality standards on a national level. Methods. A prospective, nonselected amalgamation of every aneurysm case treated in five of six neurosurgical centers
The Fra a I allergen in strawberry (Fragaria ananassa) is homologous to the major birch pollen allergen Bet v 1, which has numerous isoforms differing in terms of amino acid sequence and immunological impact. To map the extent of sequence differences in the Fra a I allergen, PCR cloning and sequencing was applied. Several genomic sequences of Fra a 1, with a length of either 584, 591 or 594 nucleo
Popular Abstract in Swedish I samband med 1990 års skattereform förändrades den allmänna inkomstskatten i grunden. Bl.a. infördes skilda skatteskalor för arbetsinkomster och kapitalinkomster. Inkomster som genereras av arbete beskattas progressivt med 45-75 % men avkastning av kapital proportionellt med 30 %. Allokering av inkomst till respektive inkomstkategori har därför stor betydelse i skattesSince the tax reform of 1990 the Swedish tax system separates earned income and capital income. On earned income such as "income from business" taxes and fees leads to a total margin tax burden that vary between 45 and 75 %. This margin effect can be compared to the 30 % proportional income tax on capital income. The allocation of income to earned income or capital income is therefore an important
Background & Aims: Human milk is believed to contain biological factors involved in the regulation of newborn growth, including brain development. Recently, it has also been shown to contain the calcium-binding S100B protein, regarded as a neurotrophic factor. The present study investigates the concentrations of this protein in colostrum, human milk at different levels of maturation and in mil
Increased nitrogen leaching from forest soils is a potential environmental problem in areas with high nitrogen deposition. In Sweden nitrogen is strongly retained in the forests, and high nitrogen leaching is not common from growing forests. However, soil water measurements on clearcuts along a deposition gradient in Sweden showed a positive correlation between increased concentration of inorganic
Glutathione peroxidase activity (GSHPx), total and soluble selenium in two muscles from five species were compared (chicken, duck, turkey, ostrich and lamb). The highest GSHPx activity, found in duck muscles (4.8 U/g; 3.0 U/g), was significantly higher than that in lamb (1.8 U/g; 1.4 U/g), turkey (1.2 U/g; 0.6 U/g), chicken (1.0 U/g; 0.7 U/g), and ostrich muscles (0.9 U/g; 0.8 U/g). GSHPx activiti
PURPOSE: A Swedish and Norwegian study was designed to examine health-related quality of life (HQL) in patients with head and neck cancer (head and neck) at diagnosis and during treatment and rehabilitation. The overall aim was to examine the impact on HQL at diagnosis depending on tumor location, stage, sex, and age (part I) and to describe HQL longitudinally and determine for which patients and
A large gravel pit 30 km north of the Pomeranian ice margin has been investigated. Besides gravel, sand, fines and diamicton, several deposits of organic material are present, some of them showing a typical Eemian Pollen- and macroflora. Previous interpretations assume that the sediments below the Eemian peat belong to the Saalian, and those above the peat to the Weichselian. Sorted sediments in t
Resuscitation with pure oxygen at birth after fetal asphyxia may aggravate brain damage by inducing pro-inflammation. The toll-like receptors (TLRs) may serve a pro-inflammatory role in hyperoxemia during ischemia-reperfusion. Sixteen near-term fetal sheep (132-136 d) were subjected to 10 min of cord occlusion, delivery and mechanical ventilation with 100% O-2 (n = 8), or 21% O-2 (n = 8) for 30 mi
Background: Limited information exists on the framework and content of postgraduate education in internal medicine in Europe. This report describes the results of a survey of postgraduate training in internal medicine in the European countries. Methods: Two online questionnaire-based surveys were carried out by the European Board of Internal Medicine, one on the practice of internists and the othe
In this study, we show a significantly reduced assay time and a greatly increased bead recovery for a commercial Luminex-based multiplex diagnostic immunoassay by performing all liquid handling steps of the assay protocol in a non-contact acoustic trapping platform. The Luminex assay is designed for detecting antibodies in poultry serum for infectious bursal disease virus, infectious bronchitis vi
Popular Abstract in Swedish Elektrostatiske vekselvirkninger mellem biomolekyler er vigtige, ikke bare i biologiske systemer, men også i flere tekniske sammenhænge. I denne afhandling studereres en række forskellige egenskaber, relevant for særligt proteiner. Således har vi ved hjælp af molekylær simulering undersøgt hvorledes proteiner vekselvirker med protoner, salte, andre peptider og proteinerElectrostatic interactions in bio-molecular systems are important not only in the living cell but also in more technical applications. Using molecular simulation as well as approximate theories the properties of a number of aqueous protein solutions have been studied. This includes interactions with other proteins, protons, charged membranes as well as flexible polyelectrolytes. The focus is on el
As the identification process is based on the unique patterns of the users, biometrics technologies are expected to provide highly secure authentication systems. The existing systems using fingerprints or retina patterns are, however, very vulnerable. One’s fingerprints are accessible as soon as the person touches a surface, while a high resolution camera easily captures the retina pattern. Thus,
