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We assessed the effects of deep brain stimulation of the subthalamic nucleus (STN-DBS) or internal pallidum (GPi-DBS) on health-related quality of life (HrQoL) in patients with advanced Parkinson's disease participating in a previously reported multicenter trial. Sickness Impact Profile (SIP) questionnaires were available for analysis in a Subgroup of n = 20/20 patients with GPi-DBS and n = 45/49
Purpose We examined whether prostate-specific antigen (PSA) forms and human kallikrein 2 (hK2) measured at age 44 to 50 years predict long-term risk of incident prostate cancer. Methods From 1974 to 1986, 21,277 men age <= 50 years in Malmo, Sweden, enrolled onto a cardiovascular study (74% participation). The rate of PSA screening in this population is low. According to the Swedish Cancer Registr
Arbuscular mycorrhizal (AM) mycelia are dependent on contact with plant roots for spore formation. In this study, earthworms and collembolans were regarded as potential dispersal vectors of AM fungal spores and hyphae, and we determined how they influenced the extension of AM fungi from host plant roots. Plantago lanceolata seedlings were grown in a mesh bag with an AM inoculurn of dried soil and
The objectives of treatment in rheumatoid arthritis (RA) are to reduce temporary symptoms due to inflammatory activity and, more importantly, to preserve function. The introduction of potent disease-modifying anti-rheumatic drugs (DMARDs) in recent years has increased the opportunities for effective treatment. However, these treatments come at a substantially higher cost than traditional DMARDs an
Although long-term repopulating hematopoietic stem cells (HSC) can self-renew and expand extensively in vivo, most efforts at expanding HSC in vitro have proved unsuccessful and have frequently resulted in compromised rather than improved HSC grafts. This has triggered the search for the optimal combination of cytokines for HSC expansion. Through such studies, c-kit ligand (KL), flt3 ligand (FL),
BACKGROUND: Primary prophylactic implantable cardioverter defibrillator (ICD) therapy is indicated for patients with reduced left ventricular ejection fraction (LVEF). We aimed to determine if preoperative clinical risk profiling can predict long-term benefit, and if clinical risk scores can be applied and improved in a patient cohort outside the clinical trial setting.METHODS: Using registry data
Developed states have what might charitably be called a schizophrenic attitude towards international refugee law. Determined to remain formally engaged with refugee law and yet unwavering in their commitment to avoid assuming their fair share of practical responsibilities under that regime, wealthier countries have embraced the politics of non-entrée, comprising efforts to keep refugees away from
In this thesis I focus on soundpainting-mediated musical experiences. Proposed in the mid seventies by the American musician Walter Thompson (b. 1952), soundpainting is a conventionalized artistic practice designed to create artistic works in real time. Thompson’s definition of soundpainting as a sign language is central to the present artistic inquiry, based on different moments of artistic pract
Background: Alzheimer's disease (AD) neuropathology is associated with neuroinflammation, but there are few useful biomarkers. Mutant variants of triggering receptor expressed on myeloid cells 2 (TREM2) have recently been linked to late-onset AD and other neurodegenerative disorders. TREM2, a microglial receptor, is involved in innate immunity. A cleaved fragment, soluble TREM2 (sTREM2), is presen
Provupparbetning är ett viktigt steg i många metoder för kemisk analys.Detta gäller framförallt fasta prover då de kemiska ämnena som avses för analys, även kallade analyter, måste extraheras ut. Det vill säga att genomföra en överföring av analyter från provet till ett lösningsmedel. Därefter kan halten bestämmas med de metoder som ofta finns till hands i ett analyslaboratorium. I de fall då fettSupercritical fluid extraction is an extraction technique suitable for lipophilic compounds from solid samples. Most commonly supercritical carbon dioxide is the main component in the extraction phase, rendering the technique relatively environmentally benign. The extraction technique is rapid due to the low viscosity and the high diffusivity of analytes in the supercritical extraction phase.The s
Background: GNE encodes UDP-N-acetyl-glucosamine-2-epimerase/N-acetylmannosamine kinase, the rate limiting enzyme of sialic acid biosynthesis. Biallelic variants in GNE have recently been associated with severe isolated macrothrombocytopenia, attributed to an increased clearance of desialylated platelets. Interestingly, treatment with the sialidase inhibitor oseltamivir has been reported to increa
One of the major research goals in ecology is to understand predator–prey interactions. However, our understanding of how prey express phenotypic plasticity in response to co-occurring multiple predators is limited in many systems. Here, we use the rotifer Brachionus calyciflorus as model organism to test how prey responds to co-occurring predators through a series of related experiments. Firstly,
Extending beyond previous research biases towards large cities or analyses based largely on one type of urban agriculture (UA) (such as market gardening, or home gardening), this research aimed to investigate all forms of UA within two intermediate-sized Ghanaian cities (Techiman and Tamale). Where was being farmed? For whom, and why? The paper considers how findings compare to Ghana's larger citi
The past three decades have seen a surge in access to information (ATI) legislation at the global level. The right to freely review government information has become a component of political liberalization movements in countries transitioning to democracy as well as reform efforts in already established democracies. ATI is seen as an important measure in fighting corruption and promoting transpare
The paper presents new geological, geochronological, geochemical, and Nd isotopic data on the late Paleoproterozoic dolerites of the Siberian craton. U-Pb baddeleyite ages of the Doros dolerites (Aldan shield, south-eastern Siberia) and East Anabar dolerites (Anabar shield, northern Siberia) are 1757 ± 4 and 1774 ± 6 Ma, respectively. This new geochronological data together with published 1.76–1.7
Primary immunodeficiencies (PIDs) are inherited disorders of the immune system with allogeneic hematopoietic stem cell transplantation (HSCT) as the only curative treatment in some of them. In case an HLA-matched donor is not available, HSCT from a haploidentical family donor may be considered. We compared the outcomes of HSCT from HLA-matched unrelated or related donors (MUDs or MRDs) and mismatc
In this work, we experimentally report the figures of merit of state-of-the-art heterostructure Tunnel Field-Effect-Transistor (TFET) arrays from room (300K) down to cryogenic temperature (10K) at supply voltages below 400mV. We demonstrate here, for the first time, that InAs/InGaAsSb/GaSb Nanowire (NW) TFETs are robust enough to maintain e
The splice variant INS-IGF2 entails the preproinsulin signal peptide, the insulin B-chain, eight amino acids of the C-peptide and 138 unique amino acids from an ORF in the IGF2 gene. The aim was to determine whether levels of specific INS-IGF2 autoantibodies (INS-IGF2A) were related to age at diagnosis, islet autoantibodies, HLA-DQ, or both, in newly diagnosed type 1 diabetes patients and controls
A commercially available fuel, E85, a blend of ~85% ethanol and ~15% gasoline, can be a viable substitute for fossil fuels in internal combustion engines in order to achieve a reduction of the greenhouse gas (GHG) emissions. Ethanol is traditionally made of biomass, which makes it a part of the food-feed-fuel competition. New processes that reuse waste products from other industries have recently
