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A double-blind, randomized, placebo-controlled cross-over multi-center study was conducted to evaluate the efficacy and safety of gabapentin in the treatment of neuropathic pain caused by traumatic or postsurgical peripheral nerve injury, using doses tip to 2400 mg/day. The study comprised a run-in period of two weeks, two treatment periods of five weeks separated by a three weeks' washout period.
Increased vascular dilatation and permeability characterize allergic rhinitis. In this study oligonucleotide microarrays (Affymetrix HuGe95A) were used to identify differentially expressed vasoactive genes in nasal biopsies from 23 patients with symptomatic seasonal allergic rhinitis (SAR) and 12 healthy controls. RNA was extracted from the biopsies and pooled in three patient and three control po
We investigated the vertical distribution, storage, landscape partitioning, and spatial variability of soil amorphous silica (ASi) at four different sites underlain by continuous permafrost and representative of mountainous and lowland tundra, in the circum-Arctic region. Based on a larger set of data, we present the first estimate of the ASi soil reservoir (0-1 m depth) in circum-Arctic tundra te
Identification and relative quantification of hundreds to thousands of proteins within complex biological samples have become realistic with the emergence of stable isotope labeling in combination with high throughput mass spectrometry. However, all current chemical approaches target a single amino acid functionality (most often lysine or cysteine) despite the fact that addressing two or more amin
Hereditary nonpolyposis colorectal cancer (HNPCC) is caused by a germline mutation in one of several DNA repair genes, which in the tumors is reflected as microsatellite instability (MSI). MSI+ tumors have been found to carry somatic frameshift mutations in mononucleotide repeats within the coding regions of several genes involved in growth control, apoptosis, and DNA repair, e.g., TGFBRII, BAX, I
Introduction: Few large studies have examined the heritability of venous thromboembolism (VTE). Moreover, twin studies have been suggested to overestimate heritability. The aim of the present study was to determine the heritability nationwide in the general Swedish population using full siblings and half-siblings. Methods: VTE was defined using the Swedish patient register. Full sibling (FS) and h
Background: Domestic violence is a global health problem as well as a violation against human rights. The aim of this study was to explore prevalence and incidence of domestic violence during pregnancy and 1 to 1.5 years postpartum as well as to explore the history of violence among new mothers in the southwestern region of Sweden. In addition, the aim was to explore the association between domest
Background: Serum creatinine-based estimates of GFR may be inaccurate in the elderly and there is need for improvement. Serum Cystatin C, not being influenced by muscle volume, may be more accurate. Material and methods: GFR was measured with plasma clearance of iohexol in 50 elderly persons aged >70 years. Blood tests were drawn for analysis of creatinine, albumin and urea. Cystatin C was analyse
Context: Test driven development (TDD) has been extensively researched and compared to traditional approaches (test last development, TLD). Existing literature reviews show varying results for TDD. Objective: This study investigates how the conclusions of existing literature reviews change when taking two study quality dimension into account, namely rigor and relevance. Method: In this study a sys
Context: The risk of many conditions, including prostate cancer, breast cancer, and osteoporosis, is associated with serum levels of sex steroids. Objective: The aim of the study was to identify genetic variations in sex steroid-related genes that are associated with serum levels of estradiol (E2) and/or testosterone in men. Design: Genotyping of 604 single nucleotide polymorphisms in 50 sex stero
This questionnaire survey was initiated to acquire information for prepration of a series of field studies. The paper deals with questions that were related to the thermal responses of the feet and footwear performance. The questionnaire was sent to a harbour, a telecommunication company and a customs office. At the harbour most of the workers used footwear with warm lining during winter. Half of
Objectives: To investigate side by side the effects on serum lipoproteins and postprandial glucose and insulin concentrations of beverages enriched with 5 or 10 g of beta-glucans from oats or barley. Design and setting: An 8-week single blind, controlled study with five parallel groups carried out at two centres under identical conditions. Interventions: During a 3-week run-in period all subject
Parasitter og cytokiner i en naturlig populasjon I naturen finner vi utallige eksempler på arter som har spesialisert seg på å utnytte andre arter for næring, trygghet og overlevelse. Denne spesialiseringen kalles parasitisme, og har ofte en kostnad for verten i form av redusert helse og livskvalitet. Hos däggdjur, er en stor parasittgruppe innvollsparasitter. nematoder som lever i tarmene og sugAbstract In nature, the coexistence of parasites and hosts has been an important factor in evolution of the immune system, which can be found in all plants and animals. As parasitic infections are by definition affect overall fitness of the host, it is important for the host to be able to counteract the detrimental effects of infections. To ensure this, signaling molecules, known as cytokines, e
Historiskt sett har människor byggt sina hus med de material som den omgivande naturen gav. Både vass och lera är två sådana material som förekommer naturligt. Det som bl.a. skiljer dessa material åt är de processer som krävs för att de ska kunna användas som taktäckningsmaterial. Vassen skördas och torkas medan leran bearbetas och bränns för att slutligen bli en användbar produkt. I tidigare svenHistorically, people built their houses with the materials that the surrounding nature gave. Reeds and clay are two such materials occurring naturally. A difference between these materials is the processes required for them to be used as roofing material. Reed is harvested and then dried while the clay is processed and fired to finally become the useful product. In earlier Swedish history roofs we
Korruption är ett begrepp som inte har någon klar definition. Det är många vetenskaper som diskuterar korruption, dock görs detta med delvis olika synvinklar. Denna framställning visar att det finns många olika perspektiv att anlägga på korruptionsproblematiken, perspektiv som dessutom leder till olika slutsatser om problematikens orsaker och verkan. Fler tvärvetenskapliga perspektiv behövs, för aCorruption is a term that has no clear definition. There are many disciplines that discuss corruption, however, this is done with somewhat different perspectives. This essay shows multiple perspectives on corruption issues, perspectives which also lead to different conclusions about the causes and effects of corruption. More interdisciplinary perspectives are needed to be able to work against corr
Denna uppsats ämnar undersöka, analysera och diskutera försvarlighetsbedömningar vid förtal enligt brottsbalken. Uppsatsen söker svaret på hur bedömningen går till samt hur den bör gå till. Undersökningen är begränsad till att omfatta förtal begångna på sociala medier då någon blivit utpekad som brottsling. Uppsatsen avhandlar även aspekten vad som är relevant vid en försvarlighetsbedömning vid föThis paper investigates, analyzes and discusses defense assessments in slander cases, as defined by the Swedish Penal Code. It looks at how assessments currently proceed rela- tive to how they could potentially be handled differently. This survey is limited to cover- ing slander committed on social media when someone has been singled out as a criminal. Our thesis also addresses what is relevant in
IgE is responsible for type 1 mediated allergic reactions, affecting an increased part of the European population. Even though a large part of the population is affected, further being an economical burden for society, little is known about the human IgE repertoire. Variation in antibodies are mainly found in antibody variable domains, and gained understanding of the IgE repertoire can be obtained
The issue of thin capitalization has risen in importance in recent years, to the point that it warranted international action. That action came in the form of Action 4 of the OECD BEPS Project, of Article 4 of the EU ATAD and of the new interest deduction limitation rules in the national Swedish legislation. The main part of the chosen rule in all these instances disallows interest deduction over
Against the backdrop of universality proposals claiming that all the world’s languages share the way they conceptualise and express THINKING, this study investigates verbs of thinking in German and Swedish in a comparative perspective. In particular, it examines semantic specificity in verbs of thinking (the restricted availability of only one specific verb in a certain context), and the potential
Medlingsinstitutet är en alternativ konflikthantering där parterna ges möjlighet att påverka konfliktens lösning och att återställa lugnet parterna emellan. Transaktioner är inte alltid friktionsfria och situationer kan uppstå där en av parterna vill föra saken inför domstol. Det är inte ovanligt att ombud i dessa situationer hotar om stämning som en skrämseltaktik för att ge sin part en hävstång.The Mediation Institute is a form of dispute resolution alternative to the judicial process where the parties may impact with the process and can influence the outcome, all in the purpose of restoring the calm between the parties. Transactions are not always successful and may result in a dispute where one party is inclined to take the dispute to court. It is not unusual that a part’s lawyer uses
