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Background: Patients with relapsing remitting multiple sclerosis (RRMS) treated with the high-efficacy drugs natalizumab (NTZ) or rituximab (RTX) generally show no evidence of disease activity. Currently, there is no head-to-head comparison between NTZ and RTX of neurodegenerative and neuroinflammatory biomarkers in cerebrospinal fluid (CSF). Objectives: To compare CSF biomarkers in a stable RRMS
BackgroundVentilation during cardiopulmonary resuscitation (CPR) has long been a part of the standard treatment during cardiac arrests. Ventilation is usually given either during continuous chest compressions (CCC) or during a short pause after every 30 chest compressions (30:2). There is limited knowledge of how ventilation is delivered if it effects the hemodynamics and if it plays a role in the
Background: There is an urgent need for effective treatments against glioblastoma (GBM). In this trial, we investigated the efficacy and safety of an adoptive cell-based immunotherapy. Methods: Patients with newly diagnosed GBM were recruited at 4 study sites in Sweden. The patients were randomized 1:2 to receive either radiotherapy (RT), 60 Gy/30 fractions, with concomitant and adjuvant temozolom
This pioneering volume explores complex local, global and digital contexts from the perspectives of Digital Theology.The use of and access to digital technology is highly contextual. It differs between regions, generations, classes, religious denominations, and gender. Which problems theologians claim to be important and which developments they ignore is contingent on their cultural, social, econo
Moisture plays a critical role in several degradation mechanisms affecting the structural components of nuclear power plants. It also significantly influences the long-term structural behaviour of reactor containments. This study presents a novel hygrothermal model that uses the relative humidity as the transport potential and accounts for the presence of a thermal gradient across the containment Moisture plays a critical role in several degradation mechanisms affecting the structural components of nuclear power plants. It also significantly influences the long-term structural behaviour of reactor containments. This study presents a novel hygrothermal model that uses the relative humidity as the transport potential and accounts for the presence of a thermal gradient across the containment
Ongoing debates on spatial justice often highlight bottom-up struggles by movements making demands on the state. This kind of narrative certainly reflects the limitations imposed by decades of neoliberal reforms that have pushed back the formal influence of grassroots in many areas. With the hegemonic formation that sustained neoliberal rule in prolonged crisis, there are now more openings for rad
Plasma levels of the neuropeptides, vasoactive intestinal polypeptide (VIP, neuropeptide Y (NPY), calcitonin gene-related peptide (CGRP), substance P, and galanin were determined in 15 hyperthyroid patients before and at 3 occassions during 38 weeks of treatment. Treatment was performed with either 131I alone or with carbimazole, with combination of carbimazole and thyroxine, or with subtotal thyr
With global politics increasingly fractured, states are rushing to secure critical and strategic mineral supply chains. Each state conceptualizes mineral security differently, driven by a mix of imperatives that range from national development and industrial policy to technological and military dominance. Great power competition pervades all of these issue areas, and that competition may also pose
Introduction: Cardiotomy suction blood is used in cardiopulmonary bypass (CPB) surgery to maintain blood volume in the CPB system, although it is known to contain micro emboli, cytokines and free plasma hemoglobin. Our aim was to investigate whether cell saver washing the cardiotomy suction blood before re-transfusing it is safe. Methods: This is a retrospective study of 1671 elective coronary art
Changes in mitochondrial DNA copy number (mtDNA-CN) and telomere length have, separately, been proposed as risk factors for various cancer types. However, those results are conflicting. Here, mtDNA-CN and relative telomere length were measured in 3225 middle-aged women included in a large population-based prospective cohort. The baseline mtDNA-CN in patients with prevalent breast cancer was signif
FK506-binding protein-like (FKBPL) has established roles as an anti-tumor protein, with a therapeutic peptide based on this protein, ALM201, shortly entering phase I/II clinical trials. Here, we evaluated FKBPL's prognostic ability in primary breast cancer tissue, represented on tissue microarrays (TMA) from 3277 women recruited into five independent retrospective studies, using immunohistochemist
BACKGROUND: Glutathione transferases (GST) are a group of multifunctional enzymes important in the detoxification of many electrophiles and, in addition, fatty acid hydroperoxides, thus limiting tissue damage from oxidative free radical attack. Of the four classes of GST (alpha, mu, pi, and theta), a class mu isoenzyme, GST mu, is dominantly inherited and is expressed in approximately half of the
BACKGROUND: It is controversial whether breast reconstruction with a microvascular free flap should be done without restrictions in patients who have not had radiotherapy. Many regard it as too expensive, but some consider it better and more economically advantageous than an implant reconstruction. METHODS: Databases of publications were searched to find out under what conditions is it suitable to
Predicted responses of transpiration to elevated atmospheric CO2 concentration (eCO2) are highly variable amongst process-based models. To better understand and constrain this variability amongst models, we conducted an intercomparison of 11 ecosystem models applied to data from two forest free-air CO2 enrichment (FACE) experiments at Duke University and Oak Ridge National Laboratory. We analysed
Looking back over 30 years of Swedish health care, professor Saltman examines structural changes in the Swedish health care sector. This is a very welcome contribution to the literature, and it makes good sense – institutional change is often a slow process, and it may take considerable time before the effects can be fully appreciated. Saltman’s paper provides a useful analytical overview of thre
Popular Abstract in English The ability to make aromatic cleft compounds is of importance in the field of molecular recognition where many interactions of the guest with the receptor are based on interactions involving aromatic receptor moieties leading to π-π and cation-π interactions, as well as hydrophobic interactions commonly seen. One attractive framework for aromatic cleft compounds is TrögThe centenarian Tröger’s base (TB) was envisaged as scaffold for the construction of tubular-shaped cleft molecules due to its the remarkable structural properties. This endeavor started with the synthesis of the three possible diastereomers of a linear symmetrically fused tris-TB analogue, the anti-anti, the syn-syn, and the syn-anti. All three diastereomers showed unprecedented stability to acid
Reverse micelle formation of the poly(ethylene oxide)/poly(propylene oxide) block-copolymer (EO)(13)(PO)(30)(EO)(13) (L64) in p-xylene was investigated as a function of water content and copolymer content, using small-angle neutron scattering (SANS). PEO/PPO block-copolymers are generally soluble in xylene but without forming aggregates. However, the effective block segregation increases dramatica
The influence of major surgery on HIV disease progression and decline in CD4+ cell count was evaluated in 23 seropositive haemophilia patients. 24 HIV-infected patients served as non-operated controls. In addition, 32 age-matched seronegative subjects were included. The follow-up time was up to 5 years. During the course of the study, eight of the operated (35%) and 11 of the non-operated (48%) su
OBJECTIVES: To explore the associations between frailty and reproductive axis hormones (as an important regulatory system) in middle aged and older men. DESIGN: Cross-sectional. SETTING: The European Male Aging Study. PARTICIPANTS: Three thousand two hundred nineteen community-dwelling European men aged 40 to 79. MEASUREMENTS: Interviewer-assisted questionnaires to assess physical activity, health
Lärarlyftskurs i juridik med start höstterminen 2024 JURIDISKA FAKULTETEN / LUNDS UNIVERSITET Höstterminen 2024 startar Juri diska fakulteten i Lund ännu en Lärarlyftskurs i juridik på distans. Det ger dig som har en behörig hetsgivande gymnasielärarexamen möjlighet att bli behörig att under visa även i juridik. Det enda som krävs är att du har en pågående anställning som lärare och att din hu
https://www.jur.lu.se/sites/jur.lu.se/files/2024-03/L%C3%A4rarlyftet%20-%20Broschyr%20(HT24).pdf - 2026-06-22
