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Background: Prostate cancer therapy with surgical or chemical castration with gonadotropin-releasing hormone (GnRH) agonists has been linked to elevated follicle-stimulating hormone (FSH) levels, which may contribute to secondary health disorders, including atherosclerosis and diabetes. Although recent findings suggest a role for FSH beyond the reproductive system, its metabolic impact remains unc
Achieving good acoustic particle or cell separation performance requires skilled operators, who must carefully fine-tune the input parameters (actuation voltages, flow rates, and flow split ratios). Often the fine-tuning is done by time-consuming parameter sweeps, which are tedious and expensive. Here, we present a straightforward model-based approach to determining input parameters that yield opt
Previous research indicates that insulin-like growth factor binding protein 7 (IGFBP7) protein levels in breast cancer tissue and blood are prognostic. However, genetic determinants of IGFBP7 in breast cancer remain largely unexplored. We examined IGFBP7 in a cohort of 1701 patients with a first breast cancer from Sweden, enrolled prior to surgery 2002-2016 and followed for up to 15 years. Genotyp
Oxygen-defective metal oxides like cerium oxides exhibit giant electrostriction and field-induced piezoelectricity due to a dynamic electrosteric interplay between oxygen defects, V O ⋅ ⋅ , and the fluorite lattice. While such mechanisms are generally attributed to oxygen vacancies, recent results also highlight that trapped cationic defects, Ce Ce ′ , i.e. small polarons, can contribute to the el
Declining butterfly abundance over recent decades coincides with both habitat loss and increasingly warmer springs. Warmer temperatures could pose a problem for ‘capital’ breeders, especially those species that enter winter diapause as a pupa or adult, since a higher metabolic rate pre-eclosion is expected to further deplete lipid stores needed for egg production. We undertook an experiment on Pie
Non-exhaust emissions from the wear of brakes, tyres, and roads have become an increasing concern in recent years, already surpassing exhaust emissions by mass in many countries. However, there is a lack of studies in the scientific literature on test methods that include both real tyre and road materials. This is crucial for accurately replicating the tribological mechanisms and resulting emissio
Background: Severe alpha-1-antitrypsin deficiency (AATD) is a known risk factor for early development of emphysema and COPD. By the Swedish national screening program within the years 1972–74 a cohort of individuals with severe AATD (PiZZ) was identified and regularly followed up. The aim of this study was to investigate alveolar volume (VA) and the ratio VA/Total lung capacity (VA/TLC) for the de
Despite the advent of advanced molecular prognostic tools, it is still difficult to predict the course of disease for cancer patients at the individual level. This lack of predictability is also reflected in many experimental cancer model systems, begging the question of whether certain biological aspects of cancer (eg. growth, evolution etc.) can ever be anticipated or if there remains an inheren
The objectives of this study were to explore active aging among people listed with an interest in relocation, and the relationships between active aging and aspects of perceived home. Using cross-sectional data from the 2022 RELOC-AGE project ( N = 1,509, mean age = 70 years), linear regression analysis was conducted. Women and individuals with higher self-rated health and education reported hig
We determined the 2025-2040 impact of climate and land use land cover change on streamflow in the Sironko catchment. LULCC was predicted using Cellular Automata Markov. The climate was statistically downscaled from the 29 GCMs of the IPCC Fifth Coupled Model Intercomparison Project using the delta method of the Agricultural Model Inter-comparison and Improvement Project under five climate regimes
Pd-Ga alloy nanoparticles with tunable compositions were produced by combining spark ablation with a downstream injection of a metal-organic precursor. This dual-process approach enables control over nanoparticle composition and morphology by adjusting precursor flow rate and sintering temperature. At lower precursor flows, uniform Pd-Ga nanoparticles form, exhibiting stable Pd5Ga2 and Pd2Ga phase
By combining the quantitative advantage of laser absorption spectroscopy and the superior spatiotemporal resolution of high-speed microscopic imaging, we report, for the first time, the transient aluminum monoxide (AlO) concentration distribution around a burning micro-sized aluminum droplet in water-vapor-rich ambient. Arrangement of two lasers at resonant and non-resonant wavelengths, respective
Single cell sequencing technologies (scRNA-seq, scATAC-seq, etc.) have revolutionized the study of complex tissues and unique organisms, providing researchers with a much needed species agnostic tool to study biological processes at the cellular level. To date, scRNA-seq technologies are expensive, require sufficient cell quantities, and need biological replicates to avoid batch effects or artifac
Proper arterial versus venous endothelial lineage identity is required to establish a hierarchical network of arteries and veins and prevent the occurrence of life-threatening arteriovenous malformations. The molecular mechanisms that govern arteriovenous lineage specification remain however incompletely understood. Here, we demonstrate that the transcription factor Prdm16 is expressed in arterial
The Iberian ribbed newt (Pleurodeles waltl) constitutes a central model for probing the basis of vertebrate regeneration. Here, we present the sequencing and chromosome-scale assembly of the 20.3Gb P. waltl genome, which exhibits the highest level of contiguity and completeness among giant genome assemblies. We uncover that DNA transposable elements are the major contributors to its expansion, wit
BACKGROUND: The predictive value of atrial conduction abnormalities, reflected by P-wave indices (PWI), and their association with biomarkers signaling fibrosis for the development of atrial fibrillation (AF) in patients with heart failure (HF) remains underexplored.OBJECTIVE: We aim to investigate the associations between PWI, fibrosis biomarkers, and the risk of incident AF in patients with HF.M
Triple-negative breast cancer (TNBC) accounts for 10-20% of primary breast cancers and often has early relapses and aggressive progression. An activated tumour immune response can be prognostic in treatment-naive and chemotherapy-treated TNBC patients and may be assessed using gene expression data. We derived a stand-alone predictor for a proposed immunomodulatory transcriptional TNBC subtype in a
Ferroelectric thin films present a powerful platform for next-generation computing and memory applications. However, domain morphology and dynamics in buried ferroelectric stacks have remained underexplored, despite their importance for real device performance. Here, nanoprobe X-ray diffraction (nano-XRD) is used to image ferroelectric domains inside BiFeO3-based capacitors, revealing local disord
This study presents the first direct measurement of aluminum monohydride (AlH) distribution and dynamics during aluminum combustion. Single micron-sized aluminum droplets were burned in a controlled H₂O/N₂/O₂ environment to ensure repeatable conditions. A dual-wavelength laser absorption imaging system is used to quantify the AlH concentration with high temporal and spatial resolution. The results
