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Conventional dendritic cells (cDC) play key roles in immune induction, but what drives their heterogeneity and functional specialization is still ill-defined. Here we show that cDC-specific deletion of the transcriptional repressor Bcl6 in mice alters the phenotype and transcriptome of cDC1 and cDC2, while their lineage identity is preserved. Bcl6-deficient cDC1 are diminished in the periphery but
The concentrations of gas-phase potassium hydroxide (KOH), potassium chloride (KCl) and atomic potassium (K(g)) were quantitatively measured from the near-surface to downstream area of burning pinewood pellets by a newly developed photofragmentation tunable diode laser absorption spectroscopy (PF-TDLAS) technique to reveal the original form of the released potassium. The novel arrangement of the P
Without intervention, cardiac arrhythmias pose a risk of fatality. However, timely intervention can be challenging in environments where transporting a large, heavy defibrillator is impractical, or emergency surgery to implant cardiac stimulation devices is not feasible. Here, we introduce an injectable cardiac stimulator, a syringe loaded with a nanoparticle solution comprising a conductive polym
Laser cladding (LC) is a promising technique to overlay a protective coating on grey cast iron (GCI) brake discs to enhance the wear and corrosion resistance. This study utilized a pin-on-disc tribometer in an aerosol chamber to investigate the tribology and airborne particle emissions from tungsten carbides (WC) reinforced coating overlayed onto GCI substrate through laser cladding. Uncoated GCI
Children's interactions with nature are important mediators of health benefits and future relationships with nature and conservation. However, there are growing concerns that children are becoming disconnected from nature as societal changes make natural environments and their affordances less accessible. There is now a need to explore ways to reconnect children to nature. We evaluated bird feedin
Many migratory animals use daylength, or photoperiod, to signal when to migrate and transition between annual phenological states. Whether animals use photoperiod as a temporal or spatial cue while migrating, however, requires additional empirical support. We used hatch-year dunnocks, Prunella modularis (a songbird), caught during their first migration in southern Sweden to elucidate whether migra
Background: Dietary habits significantly influence the risks of type 2 diabetes and cardiovascular disease. Through metabolomics, we’ve previously measured plasma metabolites to gauge dietary quality, introducing a healthy dietary metabolic signature (HDMS) linked to a decreased risk of future type 2 diabetes and coronary artery disease. Objectives: To assess the impact of a 6-day dietary interven
This article compares Swedish social workers, teachers, and journalists’ experiences of workplace violence. It addresses similarities and differences between the three professional groups in terms of who exposed them to workplace violence, what it was about, and what triggered it. The article is based on an online survey study, and the findings suggest that consumerrelated violence from target groThis article compares Swedish social workers, teachers, and journalists’ experiences of workplace violence. It addresses similarities and differences between the three professional groups in terms of who exposed them to workplace violence, what it was about, and what triggered it. The article is based on an online survey study, and the findings suggest that consumer-related violence from target gr
Micron-sized aluminum (Al) particles have recently been proposed as promising carbon-free energy carriers. To facilitate the application of micron-sized Al particles as fuel in practical energy generation system, this study experimentally investigates the underlying mechanisms of the ignition, stabilization and particle-particle collision in lifted Al particle cloud flames. High-resolution shadowg
Auger recombination is a pivotal process for semiconductor nanocrystals (NCs), significantly affecting charge carrier generation and collection in optoelectronic devices. This process depends mainly on the NCs’ electronic structures. In our study, we investigated Auger recombination dynamics in manganese (Mn2+)-doped CsPbI3 NCs using transient absorption (TA) spectroscopy combined with theoretical
Type 2 diabetes (T2D) and non-alcoholic fatty liver disease (NAFLD) often co-occur. Defining causal pathways underlying this relationship may help optimize the prevention and treatment of both diseases. Thus, we assessed the strength and magnitude of the putative causal pathways linking dysglycemia and fatty liver, using a combination of causal inference methods.Measures of glycemia, insulin dynam
ObjectiveTo report trends and characteristics of post-biopsy infections, with regard to etiology and resistance patterns, in a large unique cohort from a single-centre using the same antibiotic prophylactic regimens during a 15-year period.MethodsThis is an observational cross sectional cohort study, including all patients who underwent transrectal prostate biopsy (TR PBx) guided by ultrasound for
Individuals with rapidly progressing atherosclerotic plaques are at higher risk of experiencing acute complications. Currently, we lack knowledge regarding factors in human plaque that cause rapid progression. Using the 14C bomb-pulse dating method, we assessed the physical age of atherosclerotic plaques and which biological processes were associated with rapidly progressing plaques. Interestingly
Type 1 conventional dendritic cells (cDC1s) are rare immune cells critical for the induction of antigen-specific cytotoxic CD8+ T cells, although the genetic program driving human cDC1 specification remains largely unexplored. We previously identified PU.1, IRF8, and BATF3 transcription factors as sufficient to induce cDC1 fate in mouse fibroblasts, but reprogramming of human somatic cells was lim
The last 20 years have witnessed a marked increase in Swedish participation in major international UN-, EU- and/or NATO-led armed missions mandated according to Chapter VII of the UN Charter. This development reflects the new foreign and security priorities of Sweden in the wake of the end of the Cold War. Decisions on Swedish participation in such missions, however, cannot be taken without parlia
Background: Several studies indicate increasing hospitalisation rates for specific infectious diseases (IDs). Studies describing the entire ID spectrum are scarcer. Our aim was to describe hospital use with ID diagnoses in Swedish adults from 1998 to 2019. Methods: All four-position codes in ICD-10 were reclassified as ID or non-ID diagnoses. Using data from the National Patient Register, age-stan
Histology is a long standing and well-established gold standard for pathological characterizations. In recent years however, synchrotron radiation-based micro-computed tomography (SRμCT) has become a tool for extending the imaging of two-dimensional thin sections into three-dimensional imaging of tissue blocks, enabling so-called virtual histology with arbitrary clipping planes, volumetric renderi
The emerging notion of hematopoietic stem and progenitor cells (HSPCs) as a low-primed cloud without sharply demarcated gene expression programs raises the question on how cellular-fate options emerge and at which stem-like stage lineage priming is initiated. Here, we investigate single-cell chromatin accessibility of Lineage-, cKit+, and Sca1+ (LSK) HSPCs spanning the early differentiation landsc
We have implemented and evaluated a secondary organic aerosol scheme within the chemistry transport model TM5-MP in this work. In earlier versions of TM5-MP the secondary organic aerosol (SOA) was emitted as Aitken-sized particle mass emulating the condensation. In the current scheme we simulate the formation of secondary organic aerosol from oxidation of isoprene and monoterpenes by ozone and hyd
Purpose of Review: This article reviews controversial questions within the field of lung transplantation, with a focus on data generated within the last 3 years. We aim to summarize differing opinions on a selection of topics, including bridge-to-transplantation, intraoperative machine circulatory support, bronchial anastomosis, size mismatch, delayed chest closure, and ex vivo lung perfusion.Rece
