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Objectives: To update the EULAR recommendations for management of knee osteoarthritis (OA) by an evidence based medicine and expert opinion approach. Methods: The literature search and guidelines were restricted to treatments for knee OA pertaining to clinical and/or radiological OA of any compartment of the knee. Papers for combined treatment of knee and other types of OA were excluded. Medline a
The study describes extraction of extracellular polymeric substances (EPS) from sewage sludge by applying enzymes and enzymes combined with sodium tripolyphosphate (STPP). Additionally, a systematic study of two non-enzymatic extraction agents is described. The assessment of the released products is made by colorimetrical methods and polysaccharides/glycoconjugates identification by the interactio
Blood coagulation factor IX is composed of discrete domains with an NH2-terminal vitamin K-dependent gamma-carboxyglutamic acid (Gla)-containing region, followed by two domains that are homologous with the epidermal growth factor (EGF) precursor and a COOH-terminal serine protease part. Calcium ions bind to the Gla-containing region and to the NH2-terminal EGF-like domain. To be able to determine
Retrograde and transganglionic labeling techniques are commonly used to visualize subsets of neurons and sensory afferent projections in the nervous system. These methods commonly require anesthesia and surgical methods. However, some tracers can also be administered systemically in awake animals, thus reducing risks associated with anesthesia and surgery and allowing for labeling of neuronal popu
Apprenticeship training is a form of education that arouses a great deal of interest as regards the challenges that characterise conditions for young people on the current labour market. This is obvious both in Sweden and in other comparable countries. This chapter begin by illustrating the changed conditions for establishment of young people, a factor that may help to enhance understanding of why
OBJECTIVE: Treatments have failed to delay or stop the autoimmune process, preceding onset of type 1 diabetes. We investigated if autoantigen-specific treatment with alum-formulated glutamate decarboxylase (GAD-Alum) was safe and affected progression to type 1 diabetes in children with islet autoimmunity.METHODS: In an investigator-initiated, double-blind, placebo-controlled clinical trial, non-di
A search for heavy resonances decaying to a W or Z boson and a Higgs boson in the qq¯(′)bb¯ final state is described. The search uses 36.1 fb−1 of proton–proton collision data at s=13 TeV collected by the ATLAS detector at the CERN Large Hadron Collider in 2015 and 2016. The data are in agreement with the Standard Model expectations, with the largest excess found at a resonance mass of 3.0 TeV wit
BACKGROUND AND PURPOSE: An increasing number of radiotherapy centres is now aiming for clinical implementation of intensity modulated radiotherapy (IMRT), but--in contrast to conventional treatment--no national or international guidelines for commissioning of the treatment planning system (TPS) and acceptance tests of treatment equipment have yet been developed. This paper bundles the experience o
Background: A hip fracture is a common cause of morbidity, functional disability, and decreased health-related quality of life (HRQOL). With demographic changes showing a growing proportion of older people, hip fractures will be an increasing challenge for healthcare services in the future. Hip fractures threaten the independence of individuals in their everyday lives. In Sweden, more than one thi
Abstract: The electroweak production and subsequent decay of single top quarks is determined by the properties of the Wtb vertex. This vertex can be described by the complex parameters of an effective Lagrangian. An analysis of angular distributions of the decay products of single top quarks produced in the t -channel constrains these parameters simultaneously. The analysis described in this paper
The results of a search for new heavy W′ bosons decaying to an electron or muon and a neutrino using proton–proton collision data at a centre-of-mass energy of s=13 TeV are presented. The dataset was collected in 2015 and 2016 by the ATLAS experiment at the Large Hadron Collider and corresponds to an integrated luminosity of 36.1 fb-1. As no excess of events above the Standard Model prediction is
As an effective strategy to control the combustion of advanced combustion modes, the application of variable valve timing (VVT) in reactivity controlled compression ignition (RCCI) combustion was investigated in this study. By coupling KIVA-3V code with genetic algorithm, the combustion of a heavy-duty engine with RCCI combustion combined with VVT strategy was optimized under a wide load range. At
A search for new resonances decaying into jets containing b-hadrons in pp collisions with the ATLAS detector at the LHC is presented in the dijet mass range from 0.57 to 7 TeV. The data set corresponds to an integrated luminosity of up to 36.1 fb-1 collected in 2015 and 2016 at s=13 TeV. No evidence of a significant excess of events above the smooth background shape is found. Upper cross-section l
Säkerhet på jobbet fokuserar ofta på att skydda de anställda från fysiskt våld, utfört av externa personer som inte har någon relation till arbetsplatsen. Det är lättare att peka mot ”de andra”, de som inte hör hemma på arbetsplatsen än att komma tillrätta med arbetsplatsens interna problem. Säkerhet på jobbet i ett psykosocialt perspektiv kan därför upplevas som besvärligt att hantera och riskera
Background: Previous research suggests that sleep problems may be an important predictor for chronic widespread pain (CWP). With this study we investigated both sleep problems and fatigue as predictors for the onset of CWP over a 5-year and an 18-year perspective in a population free from CWP at baseline. Methods: To get a more stable classification of CWP, we used a wash-out period, including onl
The overall environmental impact of a product is influenced by decisions made during product development, e.g. on alternative materials. Different tools exist on how to select materials. However they are seldom adapted to a company's needs. The research question of this thesis is dedicated to this issue: Designing a material selection tool for the product development process of an organisation
In August 2008, Georgia was engaged in an internal armed-conflict with its breakaway region of South Ossetia, which shortly after, grew into a large-scale war with Russian Federation. In the course of the war, hundreds of civilians became victims of the international crimes committed by belligerent sides. Hence, the central issue of my research is a post-conflict justice. In particular, if there e
