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Lipid nanoparticles (LNPs) are the most versatile and successful gene delivery systems, notably highlighted by their use in vaccines against COVID-19. LNPs have a well-defined core–shell structure, each region with its own distinctive compositions, suited for a wide range of in vivo delivery applications. Here, we discuss how a detailed knowledge of LNP structure can guide LNP formulation to impro
We present a novel design of an electrode arrangement for measurement of the resistivity of soil samples contained in a sample cylinder used in standard geotechnical site investigations in Sweden. The objective is to make it possible to measure the resistivity of the same samples that are to be used for mechanical tests, without disturbing the samples in order to get unbiased mechanical test data.
Accurate density matrix simulation of nuclear spin systems is critical for quantifying magnetic resonance spectroscopy (MRS) data, as well as for simulation studies designed to optimize acquisition parameters. Although a variety of packages exist to achieve this result, no currently available software is capable of computing a large number of spatial points in a reasonable time frame. Here we pres
Online wall temperatures were measured with fiber-coupled phosphor thermometry in a full-scale gas turbine combustor. The combustor was operated with natural gas and up to 100 vol% hydrogen at engine-relevant conditions. Two phosphors were tested for this application, namely YAG:Dy and YAG:Tm;Li. Although YAG:Tm;Li seemed to be the most promising phosphor for this application, it turned out to be
The suitability of Hansen solubility parameters as descriptors for modelling analyte retention during reversed-phase chromatographic experiments was investigated. A novel theoretical model using Hansen solubility parameters as the basis for a complete mathematical derivation of the model was developed. The theoretical model also includes the cavitation volumes of the analytes, which were calculate
The human brain can be described as a complex network of functional connections between distinct regions, referred to as the brain functional network. Recent studies show that the functional network is a dynamic process and its community structure evolves with time during continuous task performance. Consequently, it is important for the understanding of the human brain to develop dynamic communit
We have designed a [Fe(SH)4H]− model with the fifth proton binding either to Fe or S. We show that the energy difference between these two isomers (∆E) is hard to estimate with quantum-mechanical (QM) methods. For example, different density functional theory (DFT) methods give ∆E estimates that vary by almost 140 kJ/mol, mainly depending on the amount of exact Hartree–Fock included (0%–54%). The m
PurposeTo ultimately make accurate and precise fetal noninvasive oxygen saturation (sO2) measurements by T2-prepared bSSFP more widely available by systematically assessing error sources in order to potentially reduce perinatal mortality in cardiovascular malformations and fetal growth restriction.MethodsT2-prepared bSSFP data were acquired in phantoms; in flowing blood in adults in the superior s
Place-based innovation policy for sustainability is essential for the delivery of the European Green Deal. In the current twin green and digital transition, deep societal transformations and new innovative solutions emerge in concrete territories. In this anthology, leading scholars reflect on the conditions for place-based innovation for sustainability and its consequences for directionality, str
Under mitt fältarbete kring graffiti var ”ska vi inte gå och ta en öl?” en återkommandeuppmaning bland deltagarna, även formulerad som ”gå ut och röka”, ”ta en promenad”, osv. Även om dessa förslag i sig knappast är unika för graffiti, visade sig deras betydelser och konsekvenser vara just det. I detta kapitel ska jag analysera hur dessa sociala uppmaningar användes som subkulturella eufemismer fö
Aftershock rates seem to follow a power law decay, but the assessment of the aftershock frequency immediately after an earthquake, as well as during the evolution of a seismic excitation remains a demand for the imminent seismic hazard. The purpose of this work is to study the temporal distribution of triggered earthquakes in short time scales following a strong event, and thus a multiple seismic
This study aims to fabricate nanoclay (NC) embedded polyacrylonitrile (PAN) adsorptive electrospun nanofibers (Ads-ESNs) as high performance membranes for organic micropollutants (OMPs) removal. Ads-ESN were tested using a comprehensive protocol included adsorption in batches (static) and during filtration (dynamic). The filtration performance of Ads-ESNs was tested using gravity driven membrane (
European Environmental Research Infrastructures (ENVRIs) on the ESFRI level are core facilities for providing data, research products and services from the four subdomains of Earth system science – Atmosphere, Marine, Solid Earth, and Biodiversity/Terrestrial Ecosystems. The ENVRI Cluster represents the core component of the European environmental research infrastructure landscape, with the ENVRI
BackgroundOlder adults have a high prevalence of chronic pain, which can have a substantial effect on their health and quality of life. Patients’ use of effective pain relief methods is a central part of the treatment and management of chronic pain. The utilization of pain relief methods and their perceived effectiveness are important knowledge for treating and managing chronic pain for clinicians
In this fascinating biography of the Indian revolutionary M. P. T. Acharya (1887–1954), Ole Birk Laursen uncovers the remarkable transnational networks, movements and activities of India’s most important anticolonial anarchist in the twentieth century.Driven by the urge for complete freedom from colonialism, authoritarianism, fascism and militarism, which are rooted in the idea and politics of the
