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Motivation: Multimillion-probe microarrays allow detection of gains and losses of chromosomal material at unprecedented resolution. However, the data generated by these arrays are several-fold larger than data from earlier platforms, creating a need for efficient analysis tools that scale robustly with data size. Results: We developed a new aberration caller, Ultrasome, that delineates genomic cha
Investigators in modern molecular/genetic epidemiology studies commonly analyze data on a vast number of candidate genetic markers. In such situations, rather than conventional estimation of effects (odds ratios), more accurate estimation methods are needed. The author proposes consideration of empirical Bayes and semi-Bayes methods, which yield 'adjustments for multiple estimations' by shrinking
The research community recently proposed a low-temperature combustion (LTC) concept that can simultaneously reduce Nitrogen Oxides (NOx) and soot emissions while maintaining high engine efficiency. Given that diesel fuel is prone to preignition with early injection, gasoline-like fuel with high octane number is utilised to provide sufficient ignition delay and extend the load range. Understanding
We present positivity bounds, derived from the principles of analyticity, unitarity and crossing symmetry, that constrain the low-energy constants of chiral perturbation theory. Bounds are produced for 2, 3 or more flavours with equal meson masses, up to and including next-to-next-to-leading order (NNLO), using the second and higher derivatives of the amplitude. We enhance the bounds by using the
SOCB42, 10 credits Course period: 6 February – 2 June 2024 This course is part of the virtual programme exchange Equality, Diversity, and Inclusion but can also be studied as a freestanding course.In this welcome letter you will find information about how to log in to your learning platform Canvas, where to find course literature and course registration.Mandatory introductory meetingThe course sta
Purpose: Free prostate specific antigen (PSA) in serum consists of heterogeneous molecular subforms. Recently we developed an immunoassay for selective measurement of a subfraction of free PSA called intact PSA, which has been shown to be closely associated with prostate cancer. We assessed the ability of serum intact PSA to discriminate between benign and malignant prostatic disease. Materials an
Bile acids (BAs) are known to be involved in cholesterol metabolism but interactions between the diet, BA profiles, gut microbiota and lipid metabolism have not been extensively explored. In the present study, primary and secondary BAs including their glycine and taurine-conjugated forms were quantified in serum of Apoe−/− mice by protein precipitation followed by reversed phase ultra-high-perform
Biochemical signaling is mediated by complexes between macromolecular receptors and their ligands, with the duration of the signal being directly related to the lifetime of the ligand-receptor complex. In the field of drug design, the recognition that drug efficacy in vivo depends on the lifetime of the drug-protein complex has spawned the concept of designing drugs with particular binding kinetic
High nutritional value Andean seeds—tarwi (Lupinus mutabilis), cañihua (Chenopodium pallidicaule), and quinoa (Chenopodium quinoa)—were subjected to solid-state fermentation with Levilactobacillus brevis DSM 1269. This strain can convert L-glutamic acid into the neurotransmitter GABA. Fermented tarwi exhibited the highest GABA production, at 4 mg/g sample, which correlates with its higher protein
A novel macro intermediate based on poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBHHx) was synthesized for use in the copolymerization with dimethyl amino ethyl methacrylate (DMAEMA). Methyl amino ethanol was reacted with PHBHHx to prepare a dihydroxy terminated polyester. The hydroxyl ends of the obtained PHBHHx derivatives were capped with 4,4’-azobis cyanopentanoic acid to obtain the PHBHHx
A study of university students’ beliefs about infinity and related concepts, e.g. division by zero and denseness of the number line, was conducted. The concepts were chosen for the students’ proven cognitive challenge in coping with them, and part of the study was to analyze individual beliefs of the different concepts in relation to each other. A questionnaire was designed to discover relationshi
Managers dissatisfied with salary-setting appraisals at Lund University | Saco-S Lund University Hoppa till huvudinnehåll About us Members of the Saco-S Council Board of the Saco-S Council Saco-S Council's Nomination Committee News at LU This year's salary review at Lund University – how it works Salary debt negotiations end in disagreement Managers dissatisfied with salary-setting appraisals at L
Using laser it is possible to measure the backscattered light from insects. The resulting signal can then be analysed in order to potentially determine the species of the insect. Estimating the fundamental wing beat frequency (FWBF) of insects is important in order do this classification of species, which is an area of research that has been explored previously. In this thesis, the relative phase
The stability of dispersions containing charged particles may obviously be regulated by salt. In some systems, the effective charge, as measured by the potential some small distance away from the particles, can have a sign opposite to the bare surface charge. If charge reversal takes place, there is typically a salt concentration regime within which colloidal stability increases with added salt. T
Title: Disability Free Lifetime Expectancy for men and women in Skåne using Sullivan’s Method. Author: Daniel Åström Supervisors: Jan Lanke and Juan Merlo Aim: The aim of the thesis is to investigate if differences in DFLE between genders and between 2000 and 2004 can be detected in Region Skåne Method: Using data from Region Skåne’s Folkhälsoenkät new weights for the data set have been computed a
We have compared the predictions of ligand-binding affinities from several methods based on end-point molecular dynamics simulations and continuum solvation, i.e. methods related to MM/PBSA (molecular mechanics combined with Poisson-Boltzmann and surface area solvation). Two continuum-solvation models were considered, viz. the Poisson-Boltzmann (PB) and generalised Born (GB) approaches. The non-el
Sweden has experienced a national value-based pricing (VBP) system for innovative outpatient drugs operated by the Pharmaceutical Benefits Board - LFN (now called the Dental and Pharmaceutical Benefits agency - TLV) since 2002. VBP has the character of a monopoly system, leading to reimbursement decisions where usage of new medicines is limited to subgroups and not the population for which the dru
