Filetype
Collagen-induced arthritis (CIA) is one of the most commonly used animal models for Rheumatoid arthritis (RA). CIA is induced in susceptible mouse strains after immunization with heterologous type II collagen (CII). In mice of the H-2q haplotype rat CII (rCII) is used whereas in mice of the H-2r haplotype bovine CII is utilized. The broad objective of this thesis was to gain an understanding of th
The main purpose of the present work is to increase knowledge of in-plane tension behav-iour of masonry and develop a model able to describe the impact of parameters influencing cracking caused by restrained shrinkage. In the process the mechanism of load transfer between units and mortar joints is described. The influence of cohesion between units and mortar joints, unit and joint geometry and ex
Autoignition in SI engines is an abnormal combustion mode and may lead to engine knock which is an undesired phenomenon in SI engines. It may cause damage and it is a source of noise in engines. Knock limits the compression ratio of the engine and a low compression ratio means low fuel conversion efficiency of the engine. This thesis presents a theoretical investigation about the modeling of the e
Popular Abstract in Swedish För att kunna simulera de fysikaliska fenomen som pågår i förbränning, krävs även en beskrivning av den kinetik som ingår i förbränningsprocessen. För detta ändamål utvecklas kinetiska modeller. En kinetisk modell är en lista med kemiska reaktioner och reaktionshastighetsparametrar. Modellernas tillämpningsområde begränsas av de valideringsfall och de fysikaliska parameThe simulation of physical phenomena occurring in chemical reactors requires the description of the kinetics involved in the underlying combustion process. Kinetic models are developed for this purpose. A software package, BlueBellMouse, has been developed to facilitate a deeper automatization and ease of simulation, reduction and optimization of kinetic models. A kinetic model is made of a list o
Typical for Western classical music is the process of interpreting and conveying a written score into sounding music. However, sometimes the communication of musical issues between musicians may be experienced as aggravating. In educational contexts in a broad sense, it might be advantageous if this communication could be facilitated, for example, by using visual illustrations as a complement to t
The main question of this thesis is if a practice is right because it is prescribed by an ethical theory, or if an ethical theory is right because it follows from certain practices? I propose the following definitions to illustrate the main alternatives: (1) if a practice is determined by an ethical theory and the ethical theory is not determined by practice, it is possible to speak of a top-down
With her 1953 debut Anna Rydstedt (1928-1994) immediately became part of a strong tradition of Swedish women poets, a tradition represented by authors such as Karin Boye and Edith Södergran. The debut was a furious attack on those who had thwarted her attempts to become a minister in the Church of Sweden. Rydstedt’s poetry is always existential, both in its content and process. Writing, for her, i
Popular Abstract in Swedish Den svenska grundskolan har under de senaste åren genomgått och genomgår fortfarande en stark utveckling inom ramen för den allmänna decentraliseringen i samhället. Beslut och ansvar läggs allt längre ner i organisationen. De krav som ställdes på en skolledare tillbaka i tiden var i första hand att han skulle vara administratör och den som bevakade att skolans verk-samThe issues of the study are: How do the assistant principals face the work as school leaders? Which demands of competence do the new school leaders face? Which needs of competence development exist for new school leaders? In the school studied the organization of the management was changed from one principal and one director of studies to one principal and six assistant principals. All of these we
Popular Abstract in Swedish Hormonerna vasopressin och oxytocin frisätts från hypofysens baklob. Hypofysen är en körtel, som är belägen på undersidan av hjärnan och utsöndrar en rad olika hormoner vilka i sin tur påverkar och reglerar aktiviteten i en mängd andra organ. Vasopressin medverkar till regleringen av vatten- och saltbalansen i kroppen, men verkar också sammandragande på icke-viljestyrdVasopressin and oxytocin seem to have pivotal roles in the pathophysiology of primary dysmenorrhoea and preterm labour. Prostaglandins are also involved in the regulation of uterine activity with different receptors mediating both stimulation and relaxation. We explored different aspects of synthesis, release and receptor pharmacology of vasopressin and oxytocin. We also tested a vasopressin and o
Popular Abstract in Swedish Bakgrund Hjärntumör hos barn är en relativt ovanlig sjukdom som drabbar cirka 70 barn i Sverige årligen. Under de senaste 40 åren har överlevnaden i barnhjärntumör ökat avsevärt från under 40 % till över 70 %. Överlevnaden har inte varit utan pris och många barn får kognitiva svårigheter efter behandlingen, t.ex. problem med långsamhet, dåligt minne, bristande uppmärksaBackground: Pediatric Brain Tumor (PBT) survivors suffer from cognitive sequelae, especially within the areas of cognitive tempo, attention, executive function and memory. The cognitive difficulties are often accentuated over the years, but knowledge about the long term trajectory is still scarce. Aim: The aim of this thesis was to examine cognitive sequelae after Pediatric Brain Tumor (PBT); ris
Popular Abstract in Swedish Värk i leder och muskler tillhör de vanligaste orsakerna till långtidssjukskrivningar och förtidspensioneringar. En betydande del av dessa tillstånd är orsakade av belastningsergonomiska faktorer i arbetslivet, och kan således förebyggas. Arbetsrelaterade besvär i nacke, axlar och armar är betydligt vanligare bland kvinnor än bland män. Orsakerna till detta är ofullstänWork-related musculoskeletal disorders are widespread, and are, for unclear reasons, more common among females than in males. Several risk factors have been described; constrained and awkward postures, repetitive and/or force demanding motions, and lack of recovery. The exposure to such risk factors was systematically assessed in 116 male and 206 female fish-processing industry workers. Large diff
Context. From a light curve acquired through the K2 space mission, the star K2-111(EPIC 210894022) has been identified as possibly orbited by a transiting planet.Aims: Our aim is to confirm the planetary nature of the object and derive its fundamental parameters.Methods: We analyse the light curve variations during the planetary transit using packages developed specifically for exoplanetary transi
Popular Abstract in Swedish Föräldrars involvering i skolan har under de senaste decennierna betonats allt mer i skoldebatten. Länge betraktades skolutbildning som enbart ett samhälleligt ansvar, vilket ofta medförde ett markerat avståndstagande från familjen och föräldrarna. Likt andra samhälleliga servicefunktioner har emellertid också skolan i sitt förhållande till sina användare undergått en fOver the last two decades, educational reforms have stimulated an enormous growth in innovative school thinking, effecting both independent schools and mainstream education. Parents and interest groups, previously excluded from general pedagogic practice and planning, are now faced with new opportunities and responsibilities. Parents “invest” in these newly won options in very different ways. Fail
Popular Abstract in Swedish Nästan alla träd i våra skogar lever i samspel (symbios) med svampar. Många av dessa är ”vanliga” svampar, sådana som vi är vana vid att se och plocka i naturen, (exempelvis soppar, kremlor, riskor, flugsvampar och kantareller) men det finns också de som inte bildar fruktkroppar, eller har fruktkroppar som vi inte ser. Fruktkropparna, de som kan hamna i svampkorgen, är Elevated nitrogen (N) deposition is an environmental problem that can affect plants and microorganisms, which are vital for the terrestrial N and carbon (C) cycles. This thesis has investigated the response of ectomycorrhizal fungi (EMF) to increased N deposition. Ectomycorrhizal fungi form mutualistic interactions with the roots of woody plants, including almost all boreal and temperate forests
BACKGROUND: In the prostate, the importance of sex hormones for its normal development and function is well known. However, it has been proposed that various neuroendocrine (NE) hormones and growth factors may be involved in the pathogenesis of prostatic carcinoma (CaP). Neuroendocrine differentiation appears to be associated with tumour progression and the androgen-independent state, for which th
This thesis describes an extended flamelet approach for modelling of soot formation in turbulent hydrocarbons diffusion flames. Detailed chemical kinetic mechanisms are used to compute species concentrations, temperature, density and soot formation rates as functions of flamelet coordinates in the space of mixture fraction and scalar dissipation rate. An ensemble average based on a presumed probab
Popular Abstract in Swedish Tidigare trodde man att den vuxna hjärnan inte hade någon förmåga att nybilda nervceller. Detta skulle innebära att nervceller aldrig blev ersatta om de skadades eller dog. Nu vet man däremot att den vuxna hjärnan fortfarande producerar nya nervceller från särskilda moderceller, s.k. stamceller, belägna i åtminstone två områden i hjärnan: subgranulära zonen i hippocamThe adult brain constantly produces new neurons from endogenous neural progenitor cells located in at least two regions, the subgranular zone (SGZ) in dentate gyrus of the hippocampus, and the subventricular zone (SVZ). Major efforts are underway to discover the functional significance of new neurons in the adult brain. Several studies have indicated a relationship exists between newborn hippoca
The main purpose of the pursued research is to increase knowledge of the effects of knots in structural timber so that characteristics of weaker timber may be determined and applied to improve current grading techniques. In the process, a three-dimensional fiber paradigm was established, which describes variations of local principle material axes in timber containing knots. The adaptability of the
IGF-1 is an essential regulator of fetal growth and brain development. Preterm birth in the human is followed by a rapid decrease in serum levels of IGF-1 and decreased levels of IGF-1 have been associated with development of severemorbidity. A recent clinical trial indicated that supplementation with IGF-1 prevented development of severe intraventricular hemorrhage (IVH) in extremely preterm infa
