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Background In mild asthma exercise-induced bronchoconstriction (EIB) is usually treated with inhaled short-acting beta(2) agonists (SABAs) on demand. Objective The hypothesis was that a combination of budesonide and formoterol on demand diminishes EIB equally to regular inhalation of budesonide and is more effective than terbutaline inhaled on demand. Methods Sixty-six patients with asthma (>12 ye
Abstract The ozone (O3) decomposition in the pre-heat zone of flames can initiate and accelerate the chain-branching reactions. In the present study, formaldehyde (CH2O) was investigated by both experiment and simulation methods in methane/air laminar premixed flames under atmospheric conditions. The formaldehyde concentration profiles in the flames were measured with CH2O-PLIF. When 4500 ppm of o
We present the results of 3D high-resolution calculations of the last inspiral stages and the final coalescence of neutron star binary systems. The equations of hydrodynamics are solved using the smoothed particle hydrodynamics method with up to 106 particles. Using Newtonian gravity, but adding the forces emerging from the emission of gravitational waves, we focus on the impact of microphysics on
Popular Abstract in Swedish När ett barn föds före graviditetsvecka 30 är andningsinsufficiens eller på engelska kallad respiratory distress syndrome (RDS) ett av de stora kliniska problemen som barnläkaren står inför. Redan på 1920-talet förstod man att det måste finnas ett ytspänningsnedsättande ämne i lungorna och på 1950-talet fann man att för tidigt födda (prematura) barn med RDS hade brist pUsing an animal model, the thesis explores how the initial ventilation of the lungs, and surfactant therapy, should best be managed after premature birth. Material and measurements: The studies were made in newborn lambs delivered by cesarean section. Spread of exogenous surfactant was analysed by mixing it with technetium-labelled macroaggregated human serum albumin and imaging the radioactivity
We investigate the CCN activity of freshly emitted biomass burning particles and their hygroscopic growth at a relative humidity (RH) of 85%. The particles were produced in the Mainz combustion laboratory by controlled burning of various wood types. The water uptake at sub- and supersaturations is parameterized by the hygroscopicity parameter, κ (c.f. Petters and Kreidenweis, 2007). For the wood b
Popular Abstract in Swedish Inom sjukvården används strålning för att behandla cancer. Vid strålbehandling är det viktigt att man i förväg vet precis hur strålningen ska ges till patienten för att resultatet av behandlingen skall bli bra. Ett hjälpmedel som används för detta är ett datorprogram (dosplaneringssystem) som, med utgångspunkt från patientens anatomi, beräknar hur varje enskild patient Gel dosimetry is a new dosimetry method applied in radiation therapy. Gel dosimeters consist of a radiation sensitive gel, which can integrate absorbed doses from several radiation sources or beams. The dose to the gel can be evaluated by magnetic resonance imaging (MRI), a procedure that is the focus of the present thesis. A robust tool for the evaluation of the nonuniformity in MRI has been dev
Contemporary advancements in miniaturization of analytical systems have advantageously fostered development, automation, and hyphenation of a variety of sample preparation techniques. Among several downscaled extraction designs, porous synthetic polymeric membranes (such as flat sheet (FS) or hollow fiber (HF)) have been utilized for membrane-based extraction, separating two aqueous phases (as in
Popular Abstract in Swedish Förbränning förknippas av många som förlegat. Att utvinna energi genom att ”elda” har människan gjort under årtusenden, men trots det bestod Sveriges totala energiproduktion 2004 till 52 % av förbränning. De flesta bilar, båtar, flyg och i vissa fall även tåg utnyttjar den kemiskt lagrade energin i fossila bränslen. Uppvärmningen av bostäder är inte heller att förringa,The thesis work, aimed at the development of laser-spectroscopic detection schemes, consists of three parts, concerned with the development and application of different techniques. The development of UV filtered Rayleigh scattering (FRS) for thermometry and fuel/air ratio measurements, using a frequency tripled, single-longitudinal-mode alexandrite laser at ~254 nm together with an isotopically en
Popular Abstract in Swedish De ökande kraven på högre datahastigheter inom trådlös kommunikation ställer allt högre krav på både radiosändare och mottagare, då dessa behöver utnyttja fler frekvensband med större bandbredd vid högre frekvenser. Fokus i denna avhandling ligger på högfrekvensdelen av radiomottagaren, som består av lågbrusförstärkare, blandare, och oscillatorer vid mikrovågsfrekvenserThe increasing demand for high data rates in wireless communication systems is increasing the requirements on the transceiver front-ends, as they are pushed to utilize more and wider bands at higher frequencies. The work in this thesis is focused on receiver front-ends composed of Low Noise Amplifiers (LNAs), Mixers, and Voltage Controlled Oscillators (VCOs) operating at microwave frequencies. Tra
Background: The presence of echolucent carotid plaques as defined by low ultrasound grey-scale median (GSM) is associated with a higher risk of stroke and myocardial infarction. Betablockers have shown possible anti-atherosclerotic effects. The aim of the present study was to determine if there is an association between carotid plaque GSM and treatment with betablockers. Methods: The GSM of the ca
OBJECTIVE: To study the association of physician's sex with blood pressure, lipid control, and cardiovascular risk factors in treated hypertensive men and women, stratified for the sex of their physician. METHODS: In a cross-sectional survey of hypertensive patients, 264 primary care physicians (PCPs), 187 men and 77 women from across Sweden, recruited 6537 treated hypertensive patients (48% men)
The aim of this thesis was to study onlay bone grafting in the adult rat to improve graft incorporation and perservation of graft size. In 167 adult isogeneic lewis rats, the size maintenance and bone formation at the graft-host interface of uni- and bicortical onlays positioned in various environments and treatments were investigated. The findings were assessed after four, 12 and 20 weeks with ro
Congenital haemophilia A and B are genetic disorders affecting factor VIII and factor IX production, respectively. Factor replacement is the only effective treatment for these deficiencies, but a patient's immune system can develop inhibitory antibodies which bind and interfere with the function of the replaced factor in a variety of ways. The main treatment goal for patients with inhibitors is to
In pristine Sphagnum-dominated peatlands, (di)nitrogen (N2) fixing (diazotrophic) microbial communities associated with Sphagnum mosses contribute substantially to the total nitrogen input, increasing carbon sequestration. The rates of symbiotic nitrogen fixation reported for Sphagnum peatlands, are, however, highly variable, and experimental work on regulating factors that can mechanistically exp
When on September 15, 2008 the financial conglomerate Lehman Brothers files for bankruptcy – and with that ‘officially’ sparks off the international financial crisis – few would have anticipated the invasive effect this crisis would come to have on the professional and personal lives of many across the world. Today, this implosion remains a mere ‘blip’ in the universe of events that ensued. On c
The overall objective of this thesis is to understand the role of diversification at household level, its patterns, determinants and effects on rural smallholder farmers in SSA, as well as its implications for the process of structural transformation in SSA. In the thesis, I use a mixed methodology and combine different types of data on rural smallholders in SSA to answer the objectives a review o
Chronic neural interfaces that are able to record or stimulate neurons in the CNS are valuable instruments in use today and they hold great promise for the future both within neuroscience research and in the clinic. However, a major obstacle is that they show a decline in performance over time. Many different approaches to improve the interface designs are gradually evaluated in hope of overcoming
The relation between use of sunscreens, different host factors and malignant melanoma was investigated in a population-based, matched case-control study of malignant melanoma in the South Swedish Health Care Region, which has the highest risk for melanoma in Sweden, between 1 July 1988 and 30 June 1990. In total, 400 melanoma patients and 640 healthy controls aged 15-75 years answered a comprehens
It is important that climate models can accurately simulate the terrestrial carbon cycle in the Arctic due to the large and potentially labile carbon stocks found in permafrost-affected environments, which can lead to a positive climate feedback, along with the possibility of future carbon sinks from northward expansion of vegetation under climate warming. Here we evaluate the simulation of tundra
Purpose: High plasma copeptin, a marker of vasopressin, predicts diabetes mellitus. We tested if copeptin could be suppressed by increased water intake in healthy individuals, and if a water-induced change in copeptin was accompanied by altered concentrations of glucose, insulin or glucagon. Methods: Thirty-nine healthy individuals underwent, in random order, 1 week of high water intake (3 L/day o
