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Sustainable access to effective antibiotics is a main rationale for addressing antimicrobial resistance, for calls to enhance antibiotic supply security and for development support to promote health system capacity in low- and middle-income settings. Standard models for valuing pharmaceuticals fail to capture the full value of sustainable access to effective antibiotics. In effect, assessments of
The topic of the thesis is re-initialization of multistep methods for the solution of ordinary differential equations, in which there are frequent discontinuities in first or higher derivatives. There are self-starting algorithms to start or restart a multistep method. It is normally started by first using a one-step method and then increasing the order successively until the working order is reac
Under 1990-talet genomfördes flera omdiskuterade humanitära interventioner. De som var kritiska hävdade att interventionerna var en oacceptabel kränkning av suveränitetsprincipen. Förespråkare menade att respekten för mänskliga rättigheter var ett viktigare intresse att skydda. 2001 släpptes en rapport som fick stor betydelse för den globala utvecklingen på området. I rapporten lanserades koncepteDuring the 1990s there were several controversial humanitarian interventions. Critics argued that the interventions were an unacceptable violation of the principle of sovereignty. Proponents argued that the respect for human rights was an interest of more importance. In 2001 a report that was of great importance for the continued global development was released. The report launched the concept of
In other hazardous complex socio-technical systems in society, e.g. nuclear power and aviation, systems-theoretical assumptions are considered a promising way to better understand and manage safety. In this paper, two fundamental approaches to road safety were assessed in the light of a systems theory approach. One approach, is based on a premise where individual road-users are solely responsible
We have developed a method to estimate free energies of reactions in proteins, called QM/MM-PBSA. It estimates the internal energy of the reactive site by quantum mechanical (QM) calculations, whereas bonded, electrostatic, and van der Waals interactions with the surrounding protein are calculated at the molecular mechanics (MM) level. The electrostatic part of the solvation energy of the reactant
Nanowires are structures with features on the nanoscale, and it is therefore essential to study their properties on that scale. We present optical data from a variety of nanowire-based structures using cathodoluminescence imaging and spectroscopy. One important feature of nanowires is the stacking sequence of the crystal, either zincblede, wurtzite or a mix of the two. We show that this has an imp
Screening for type 1 diabetes (T1DM) risk in newborns has little negative emotional impact on mothers. In this study, the impact on the mother and the father was evaluated both in the general population and in families with diabetes. All parents with a newborn in Skåne, Sweden, were invited to a screening for T1DM risk in their children (the Diabetes Prediction in Skåne (DiPiS)). Blood was obtaine
Abstract in UndeterminedThe recent MPEG Reconfigurable Media Coding (RMC) standard aims at defining media processing specifications (e.g. video codecs) in a form that abstracts from the implementation platform, but at the same time is an appropriate starting point for implementation on specific targets. To this end, the RMC framework has standardized both an asynchronous dataflow model of computat
Chronic groin postherniorrhaphy pain (CGPP) is common and sometimes so severe that surgical treatment is necessary. The aim of this study was to identify risk factors for being reoperated due to CGPP.
The new challenge for a construction project management is to meet the demands of sustainable construction, defined by ecological, economical, social and cultural variables. During a facilities lifecycle various activities involves a significant number of stakeholders. It could be those stakeholders who directly are involved, e.g. architects, facility managers or users, and those who more or less
Popular Abstract in Swedish Nanotekniken håller i skrivande stund på att revolutionera samhället med nya innovationer inom exempelvis elektronik och medicin. En viktig del i detta är utvecklingen av nya och förbättrade sätt att avbilda strukturer av nanometerstorlek (en nanometer är en miljarddels meter). Avancerade karakteriseringsmetoder skapar en ökad förståelse för hur nanostrukturer beter sigUltrafast nano-optics is a new and quickly evolving research field centred around the control, manipulation, and application of light on a nanometre and femtosecond scale. This can lead to improved electro-optical devices, more sensitive spectroscopy, and real-time control of chemical reactions. However, understanding the simultaneous nanometre and femtosecond evolution of nano-optical fields requ
Popular Abstract in Swedish Betydelsen av tryckinducerad syrgastransport hos övervattensväxter Min avhandling handlar om vikten av att syrgas transporteras till rötter och rhizom hos övervattensväxter som bladvass, kaveldun och säv. Syrgas behövs för cellandningen i alla växtdelar, och i synnerhet i rötterna då de växer fort och har hög ämnesomsättning. Övervattensväxter har rötterna i vattendränThis thesis examines factors regulating growth and distribution of emergent plants with focus on effects of oxygen supply to the roots. Greenhouse experiments revealed that P. australis acclimatizes to specific water depths with phenotypic plasticity. These phenotypic responses act to increase growth at specific water depths but may result in decreased tolerance to changed water depth. Oxygen nee
Popular Abstract in Swedish Elektroencefalogrammet (EEG), dvs mätning av potentialer på skalpen, är en relativt enkel och gammal teknik för att studera hjärnans aktivitet. Trots de stora framstegen inom s k brain-mapping-tekniker på senare år (magnetröntgen, PET, SPECT), är EEG fortfarande ett viktigt verktyg för diagnos. En av dess fördelar gentemot andra tekniker är dess fina tidsupplösning. EtThe thesis treats methods for pattern recognition in multichannel electroencephalogram (EEG) signals, for application to diagnostics of epilepsy. Parts I-IV treat methods for feature extraction and clustering of EEG spikes, occurring between epileptic seizures, and part V presents a method for filtering seizure onset EEG signals. In part I, Hermite functions are used for parametric description of
In this second issue on the scholar and public intellectual Yu Jianrong, we address some of the topics that have been at the core of his academic work and where his research and views have helped shaped awareness of these issues among the general public and the academic community. We focus on the rural-urban divide, land issues (including land confiscations and property demolitions), the letters a
The high frequency of contact allergy to gold in patients with dermatitis was established after exhaustive skin testing, determining the right test agent, the best concentration, and repeated test readings. Metallic gold in contact with skin is slowly ionized, permitting absorption and haptenisation. Contact allergy to gold is statistically correlated to the presence of dental gold. But in many ca
Post-silicon validation and debug, or ensuring that software executes correctly on the silicon of a multi-processor system-on-chip (MPSOC) is complicated, as it involves checking global properties that are distributed on the chip. In this paper we define an architecture to non-intrusively observe global properties at run time using distributed monitors. The architecture enables to perform actions
Voltage collapse was one of the main causes for many recent blackouts. The direct link between voltage stability and reactive power balance in the system leads to more attention toward reactive power resources in the power systems. Shunt reactors and capacitors are used to balance reactive power in the power systems. The strategy to control them in both normal and emergency conditions is an import
Popular Abstract in Swedish Behandling med radionuklidterapi baseras på radioaktiva läkemedel, d.v.s. läkemedel som i sig består av ett radioaktivt ämne, eller som kopplats till en radionuklid. Den strålningsenergi som avges vid de radioaktiva sönderfallen absorberas i vävnad och ger en lokalt absorberad stråldos där läkemedlet tas upp. Viktigt är härvid att upptaget är högre i patologisk vävnad äIndividual-based determinations of the absorbed dose in radionuclide therapy largely rely on absolute measurement of the activity distribution and its redistribution over time. Scintillation-camera imaging is the most commonly employed measuring technique, applied in planar or SPECT mode, sometimes in combination with structural images from CT. In this thesis, methods for processing and analysis o
