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Regulation of HPV16 splice sites located in the E6/E7 oncogene coding region

Kan cellers proteiner bota HPV- sjukdomar? Livmoderhalscancer är en av de vanligaste cancersjukdomarna som drabbar kvinnor världen över. Varje år, diagnostiseras ungefär 500 000 kvinnor och 270 000 dör i sjukdomen, varav de flesta dödsfallen sker i utvecklingsländer. Livmoderhalscancer orsakas av det vanligt förekommande viruset humant papillomvirus (HPV) och för att hitta bättre behandling mot sHuman papillomaviruses (HPVs) are small DNA viruses that have evolved over millions of years and are well-adapted to humans. Persistent infections with HPVs, can result in cancer development. There are over 200 different HPV types that can be divided into high- and low risk types based on their ability to cause cancer. HPV16 is the most common high- risk type that accounts for more than 50 % of al

Finding potential sites for small-scale hydro power in Uganda : a step to assist the rural electrification by the use of GIS : a minor field study

Populärvetenskaplig sammanfattning: Mer än två miljarder människor, mestadels i utvecklingsländer, saknar tillgång till moderna energikällor eller elektricitet. Behovet av rena, effektiva, pålitliga och ekonomiskt överkomliga energitjänster är en viktig fråga i utvecklingsländer, särskilt för landsbygden, där merparten av befolkningen bor. Förnyelsebara energikällor i form av småskaliga vattenkrafOver 2 billion people, mostly in developing countries, have no access to modern fuels or electricity. The necessity of clean, efficient, reliable and affordable energy services is a crucial issue in developing countries, especially in the context of rural areas where the majority of the people lives. Renewable energy sources in shape of small-scale hydropower systems are a complement or alternativ

Cultural Heritage, Our Shared Legacy: A Study of Value Co-Creation in Archaeological Site Management

Cultural tourism and cultural heritage management, while distinct disciplines with differing foci, are also inherently intertwined. However, conflicts between the two often arise due to the diverse number of stakeholders and interests involved in either the travel industry or the conservation and protection of cultural heritage. Despite this, cultural tourism can greatly benefit the conservation o

Source contributions in precipitation chemistry and analysis of atmospheric nitrogen deposition in a Sahelian dry savanna site in West Africa

Experimental data on precipitation chemistry were collected at a semi-arid savanna in Senegal (Dahra) in 2013, 2014 and 2017. The chemical composition of precipitation was analyzed for inorganic and organic ions, using ionic chromatography. The pH values of precipitation range from 4.50 to 8.50 with 89% of the samples having basic pH. The composition of precipitation was controlled by four source

Site Characteristics Mediate the Relationship Between Forest Productivity and Satellite Measured Solar Induced Fluorescence

Solar-Induced Chlorophyll Fluorescence (SIF) can provide key information about the state of photosynthesis and offers the prospect of defining remote sensing-based estimation of Gross Primary Production (GPP). There is strong theoretical support for the link between SIF and GPP and this relationship has been empirically demonstrated using ground-based, airborne, and satellite-based SIF observation

Coincidence study of core-ionized adamantane: Site-sensitivity within a carbon cage?

We investigate the fragmentation dynamics of adamantane dications produced after core-ionization at the carbon edge followed by Auger decay. The combination of high-resolution electron spectroscopy, energy-resolved electron-ion multi-coincidence spectroscopy and different theoretical models allows us to give a complete characterization of the processes involved after ionization. We show that energ

The ethics and politics of world heritage : local application at the site of Laponia

This article explores the ethics of world heritage (WH) through a cosmopolitan lens. It proposes that cosmopolitanism provides fertile ground for the study of WH, in particular if combined with sensitivity to distinct indigenous ethical and political claims. Underpinning my article is the question of whether the politics of WH, despite its peaceful and universalist intensions, obscures local dispu

Conformational Response of 30S-bound IF3 to A-Site Binders Streptomycin and Kanamycin

Aminoglycoside antibiotics are widely used to treat infectious diseases. Among them, streptomycin and kanamycin (and derivatives) are of importance to battle multidrug-resistant (MDR) Mycobacterium tuberculosis. Both drugs bind the small ribosomal subunit (30S) and inhibit protein synthesis. Genetic, structural, and biochemical studies indicate that local and long-range conformational rearrangemen

Analysis of particle size distribution changes between three measurement sites in Northern Scandinavia

Measured aerosol size distributions from three measurement stations and modeled air mass trajectory data were combined to study aerosol dynamics in the boreal forest zone in Northern Scandinavia. Three approaches were used: investigation of new particle formation events, analysis of air masses arriving from ocean to continent, and study of changes in the aerosol size distributions when air masses

A blood test to monitor bee health across a European network of agricultural sites of different land-use by MALDI BeeTyping mass spectrometry

There are substantial concerns about impaired honey bee health and colony losses due to several poorly understood factors. We used MALDI profiling (MALDI BeeTyping®) analysis to investigate how some environmental and management factors under field conditions across Europe affected the honey bee haemolymph peptidome (all peptides in the circulatory fluid), as a profile of molecular markers represen