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Generalization of prostate cancer classification for multiple sites using deep learning

Deep learning has the potential to drastically increase the accuracy and efficiency of prostate cancer diagnosis, which would be of uttermost use. Today the diagnosis is determined manually from H&E stained specimens using a light microscope. In this paper several different approaches based on convolutional neural networks for prostate cancer classification are presented and compared, using th

The application of resistivity and IP-measurements as investigation tools at contaminated sites : a case study from Kv. Renen 13, Varberg, SW Sweden

Kv. Renen 13 i centrala Varberg är sedan tidigare känt som kraftigt förorenat. På fastigheten har det från slutet av 1800-talet fram till 2003 funnits verksamheter i form av textilindustri som avlösts av finmekanisk verkstadsindustri. Det är framförallt den sistnämnda verksamheten som har orsakat rådande situation med höga halter klorerade lösningsmedel, trikloreten (TCE) och 1,1,1-trikoletan (TCAAn old industry estate, Kv. Renen 13, is located in central Varberg, southwest Sweden, and is known from previous investigations as highly polluted. Pollution started in the late 19th century with textile manufacturing, and in the 1960´s changed into a precision mechanics industry using chlorinated solvents, primary trichloroethene (TCE) and 1,1,1-trichloroethane (TCA), as well as cyanide and meta

Application of the eddy-covariance method under the canopy at a boreal forest site in central Sweden

Popular science The eddy-covariance (EC) method is one of the most important methods to measure gas and energy fluxes between biosphere and atmosphere at ecosystem level. This method was applied above the floor of a boreal forest in Norunda, central Sweden, at 1.5 m height. The objective was to measure the energy and carbon dioxide (CO2) fluxes from the soil and the understory vegetation to the at

Lymph node metastases as only qualifier for stage IV serous ovarian cancer confers longer survival than other sites of distant disease – a Swedish Gynecologic Cancer Group (SweGCG) study

Background: The International Federation of Gynecology and Obstetrics (FIGO) ovarian cancer staging system includes no sub-stage for lymph nodes (LN) as only distant disease manifestation. We explore the prognostic implication of LN as only stage IV classifier in serous ovarian cancer. Method: This is a nation-wide, population-based study on 551 women with serous stage IV cancers diagnosed between

Phosphorylation sites of Arabidopsis MAP kinase substrate 1 (MKS 1)

The Arabidopsis MAP kinase 4 (MPK4) substrate MKS1 was expressed in Escherichia coli and purified, full-length, 6x histidine (His)-tagged MKS1 was phosphorylated in vitro by hemagglutinin (HA)-tagged MPK4 immuno-precipitated from plants. MKS1 phosphorylation was initially verified by electrophoresis and gel-staining with ProQ Diamond and the protein was digested by either trypsin or chymotrypsin f

A European aerosol phenomenology-5 : Climatology of black carbon optical properties at 9 regional background sites across Europe

A reliable assessment of the optical properties of atmospheric black carbon is of crucial importance for an accurate estimation of radiative forcing. In this study we investigated the spatio-temporal variability of the mass absorption cross-section (MAC) of atmospheric black carbon, defined as light absorption coefficient (σap) divided by elemental carbon mass concentration (mEC). σap and mEC have

Detection by near-infrared spectroscopy of large lipid cores at culprit sites in patients with non-st-segment elevation myocardial infarction and unstable angina

ObjectiveThis study was performed to assess the lipid burden of culprit lesions in non-ST-segment elevation myocardial infarction (non-STEMI) and unstable angina (UA). BackgroundA recent intracoronary near-infrared spectroscopy (NIRS) study showed 85% of STEMI culprit lesions have a maximum lipid core burden index in 4-mm (maxLCBI(4mm))400. Whether culprit lesions in non-STEMI and UA are character

Healthcare utilization for somatic conditions among Swedish patients in opioid substitution treatment, with and without on-site primary healthcare

Background: Opioid substitution treatment (OST) populations are aging and have increased mortality and somatic morbidity compared to general populations internationally. While OST patients have poor self-rated physical health and unmet healthcare needs, documented healthcare utilization has been sparsely investigated. The aim of this study was to assess registered healthcare utilization for somati