Filetype
Large skeletal muscle injuries, such as a volumetric muscle loss (VML), often result in an incomplete regeneration due to the formation of a non-contractile fibrotic scar tissue. This is, in part, due to the outbreak of an inflammatory response, which is not resolved over time, meaning that type-1 macrophages (M1, pro-inflammatory) involved in the initial stages of the process are not replaced by
Hindlimb ischemia is an unmet medical need, especially for those patients unable to undergo vascular surgery. Cellular therapy, mainly through mesenchymal stromal cell (MSC) administration, may be a potentially attractive approach in this setting. In the current work, we aimed to assess the potential of the combination of MSCs with a proangiogenic elastin-like recombinamer (ELR)-based hydrogel in
Volcanic eruptions can have severe societal and environmental impacts as shown by ash dispersal and sulphur emissions from recent Icelandic eruptions. However, ice-core sulphur records demonstrate that these events were minor as compared to eruptions of much larger magnitude in recent centuries, with severe implications for past society documented in historical records. Biological and chemical evi
There is a global concern about the decline of wild pollinators and the ecosystem services they provide. Although land-use change is a major threat to biodiversity, it is still poorly understood how land-use heterogeneity (or land-use structure) impacts pollinator communities and entomophilous crop production. Based on a literature review, we performed a meta-analysis to (1) assess how landscape s
Determining the appropriate duration for traffic conflict observation remains a critical yet unresolved challenge in road safety analysis. Existing approaches lack a quantitative approach to determine adequate sample sizes for general conflict-based applications. This study addresses this gap by proposing an extreme value theory based framework to determine appropriate observation durations, based
Pathogenic bacterial infections lead to bacterial resistance and biofilm formation, causing significant suffering and presenting an urgent issue to be addressed. Polymer materials have garnered considerable attention in the antibacterial field due to their functional moldability and molecular structure designability. These materials can achieve various antibacterial functions by regulating their m
Combined quantum mechanics and molecular mechanics (QM/MM) calculations are a popular approach to study reaction mechanisms of enzymes. However, recently, the reproducibility of such calculations has been questioned, comparing the results of two software: NWChem and Q-Chem. Here, we continue and extend this study by including three additional software─ComQum, ORCA, and AMBER─using the same test ca
Background: Peritoneal recurrence (PREC) following nephrectomy for localized renal cancer (RCC) is rare. Our objective was to report a multicenter analysis of PREC to analyze incidence, treatment, survival and risk factors. Methods: Between 1987 and 2023, patients with PREC following radical or partial nephrectomy (PN) for localized RCC across ten European institutions (UroCCR, NKI, IRCCS, Foch an
Background: Dose-dense (DD) adjuvant chemotherapy improves outcomes in early breast cancer (BC). However, there are no phase 3 randomized data to inform on its combination with trastuzumab for patients with human epidermal growth factor receptor 2 (HER2)–positive disease. Methods: This was a protocol-predefined secondary analysis of the randomized phase 3 Pan-European Tailored Chemotherapy (PANTHE
Title: Multi-Sided Platforms: Understanding their strengths and weaknesses Seminar date: 2014-05-22 Course: FEKN90 Företagsekonomi: Examensarbete på Civilekonomprogrammet (30 ECTS) Authors: Lucas Ehrenstråhle and Elin Mathies Supervisor: Magnus Johansson Five keywords: MSP, activities, resources, differentiation and platforms The purpose: is to investigate why small actors use multi-sided pl
This study investigates how lead content and bioavailability in soil affects growth and root/shoot ratio in three commonly cultivated species: wheat (Triticum turgidum), clover (Trifolium) and radish (Raphanus sativus). The study investigates the levels at which soil lead content contribute to toxic effects in plants, and when it may pose a risk to consumers. In addition, lead accumulation and the
Communication today is not something merely taking place face to face, technology such as the internet and social media channels have opened up for endless interactions taking place in the online world. User generated content in the form of online travel reviews come with many challenges and opportunities for organizations. User generated content has been shown to impact a travelers decision in al
This thesis investigates how AI-generated music challenges traditional systems of cultural legitimacy, identity, and musical taste. Drawing on Bourdieu’s theory of cultural fields and symbolic capital, and supplemented by Simon Frith’s insights into authenticity and identity performance, the study examines how emerging technologies reconfigure creative authority within platform-driven environments
MORC2 (Microorchidia CW type Zinc Finger protein 2) is a GHKL (gyrase, heat shock protein 90, histidine kinase, MutL) ATPase involved in chromatin remodeling and is highly conserved in eukaryotes. Mutations in the ATPase domain of MORC2 are known to cause neurodevelopmental disorders. MORC2 is recruited by the HUSH complex to target long, intronless transcription units such as LINE-1 retrotranspos
Background: Estrogen receptor alpha (ERα) is a protein that belongs to the nuclear receptor family. It is regulating the expression of genes involved in cell cycle progression, proliferation, and apoptosis. Approximately 75% of breast cancers express ERα, making it an important target for treatment. Researchers have identified various isoforms of ERα, with the most well-characterized one being a 6
För att lösa dagens bostadsbrist utan att det sker på bekostnad av värdefull mark, satsar en övervägande del av de svenska kommunerna på förtätning. Den främsta fördelen med att bygga tätt är att det optimerar förutsättningarna för variation i serviceutbudet och leder till ett effektivare utnyttjande av infrastrukturen. Dock påstår många att nya bostäder i samband med förtätning skulle ge värdesänIn order to solve housing shortage while preserving valuable land, a majority of the Swedish municipalities are implementing densification as a planning strategy. Denser development provides better support for a variety of services and optimizes public transportation. Despite the several benefits, infill development is commonly claimed to lower nearby housing prices. Studies on whether new residen
Single-domain antibody fragments, also called nanobodies, that target the spike glycoprotein of SARS-CoV-2 can potently neutralize the virus and prevent infection. In our first aim, we investigated whether their neutralization potency can be further increased by multimerization and generated multivalent constructs of a recently identified SARS-CoV-2 neutralizing nanobody, Ty1. We applied a novel m
I mitt examensarbete har jag arbetat med ett projekt i kommunen där jag bor, nämligen i Svedala. Här har det länge funnits en önskan om en attraktiv simhall från invånarnas sida, men ännu finns det ingen i kommunen. Därför tar jag chansen - på eget initiativ av mig som fristående arkitektstudent - att i mitt examensarbete gestalta ett hållbart badhus åt Svedalas invånare. Arbetet är upplagt på sIn my degree project, I have worked on a project with a sustainable swimming hall in the municipality of Svedala, where I live. Still, there is no swimming hall in the whole municipality, altough there has been an increased desire to create an attractive one that considers the needs of the residents. Therefore, I took the initiative - as an independent architecture student - to propose and design
