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Protein ADP-ribosylation is a reversible post-translational modification that regulates important cellular functions. The identification of modified proteins has proven challenging and has mainly been achieved via enrichment methodologies. Random mutagenesis was used here to develop an engineered Af1521 ADP-ribose binding macro domain protein with 1000-fold increased affinity towards ADP-ribose. T
Lymphocytes from human peripheral blood were separated by Countercurrent distribution (CCD) in a charged aqueous two-phase system composed of Dextran T 500 and polyethylene glycol 6000. Maximal responses to the T-cell mitogens phytohemagglutinin and concanavalin A were detected in a part of the distribution corresponding to the area where the highest percentage of E rosetting cells were seen. Anti
Regular prophylactic treatment with factor VIII (FVIII) and factor IX (FIX) concentrates in hemophilia A and B, respectively, is introduced in early infancy and has resulted in dramatic improvement of the conditions. Recombinant FVIII and FIX concentrates have been available for > 25 years and have been modified and refined through the years; however, unfortunately frequent intravenous administrat
We have characterized 2 distinct mechanisms through which infectious agents may promote platelet adhesion and thrombus formation in flowing blood, thus contributing to the progression of disease. In one case, the process initiates when the integrin alpha(IIb)beta(3) mediates platelet arrest onto immobilized bacterial constituents that have bound plasma fibrinogen. If blood contains antibodies agai
EndoS from Streptococcus pyogenes efficiently hydrolyzes the functionally important and conserved N-linked glycan of IgG in human blood. Repeated i.v. administration of EndoS in rabbits completely hydrolyzes the glycans of the whole IgG pool, despite the generation of anti-EndoS antibodies. EndoS administration had no apparent effects on the health of the animals. EndoS hydrolysis of the IgG glyca
Background: A unique feature of alveolar mast cells is their low high-affinity IgE receptor (FcεRI) expression. Recent discoveries in uncontrolled asthma suggest that the appearance of FcεRI-expressing alveolar mast cells may be a novel disease-specific feature of allergic asthma. This study investigates whether increased FcεRI-expressing alveolar mast cells are present in patients with mild aller
16 april 2026 13:15 till 14:30 | Seminarium Presentation by Andreas Bandak, University of Copenhagen. Joyful crowds toppling statues, unsealing torture prisons, defacing regime iconography, ordinary people roaming freely through Al-Asad’s Presidential Palace . . . images such as these have left us in no doubt that history was being made, and in the most dramatic way: the old order—that had seemed
https://www.lu.se/evenemang/cmes-seminar-worlds-waymaking-viability-orientation-and-recalibration-syrian-lives - 2026-06-20
Publicerade vetenskapliga arbeten från DiPiS-studien Genetic and perinatal factors as risk for childhood type 1 diabetes.K. Larsson, H. Elding-Larsson, E. Cedervall, K.Kockum, J. Neiderud, S. Sjöblad, B. Lindberg, B. Lernmark, C. Cilio, S.A. Ivarsson, Å. Lernmark.Diabetes Metabolic Research and Review 20(6): 429-37, 2004. Parent responses to participation in genetic screening for diabetes risk.B.
https://www.teddy.lu.se/alla-studier-i-cap/avslutade-studier-i-cap/dipis/lista-over-forskningsresultat-fran-dipis - 2026-06-19
Go directly to checklist for managers Checklist for the person who have been exposed to threats or violence At the time of the event: Try to mitigate the threat by acting calm. Keep a safe distance. In case of violence try to escape. If possible, try to alert others to the situation, seek help from fellow employees or other people nearby. In case of an emergency (threats or violence): call the p
https://www.hr-webben.lu.se/checklist-case-threats-and-violence - 2026-06-19
Professor Kontaktinformation E-post: tomas [dot] hellstrom [at] fek [dot] lu [dot] se Telefon: +46 46 222 80 27Organisation Strategi Rumsnummer: Alfa 5,6 rum B423 Hämtställe: 10 WebbplatsTomas Hellströms profil i Lunds universitets forskningsportalAndra roller Facklig förtroendeman ST vid Lunds universitet Professor CIRCLE Publikationer Visar av publikationer. Sorterade efter år och sen titel. Fil
https://www.ehl.lu.se/tomas-hellstrom - 2026-06-19
Popular Abstract in English The human plasma proteome containing disease-correlated protein biomarkers reflects the pathological and physiological changes relating to diseases. These biomarkers are of interest to aid in diagnosis, prognosis and monitoring of diseases such as cancer. Because of the interests in the disease-correlated biomarkers, plasma, although is a complex biological sample, spanThe blood/plasma protein biomarker profile represents the pathological and physiological changes relating to human diseases. However, the plasma proteome reflects a high degree of complexity that results in a challenge for most analytical methods in clinical diagnostics. The focus in this thesis is the development and application of several integrated platforms to detect already established protei
