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Numerous applications all the way from biology and physics to economics depend on the density of first crossings over a boundary. Motivated by the lack of general purpose analytical tools for computing first-passage time densities (FPTDs) for complex problems, we propose a new simple method based on the independent interval approximation (IIA). We generalise previous formulations of the IIA to inc
Axonal damage, a core feature of neurological diseases, induces a retrograde reaction in neurons and surrounding glia. We determined transcriptional profiles of this reaction using Affymetrix oligonucleotide arrays. Gene expression was examined in spinal cord tissue prior to injury and following ventral root avulsion in two inbred rat strains, where the degree of neurodegeneration differs. Stringe
Context Gestational diabetes is commonly linked to development of type 2 diabetes mellitus (T2DM). There is a need to characterize metabolic changes associated with gestational diabetes in order to find novel biomarkers for T2DM. Objective To find potential pathophysiological mechanisms and markers for progression from gestational diabetes mellitus to T2DM by studying the metabolic transition from
The results from a round-robin study in which practicing fire safety engineers simulated the same scenario are presented in this paper. The simulation task included the simulation of an 800 mm heptane pool in a three-room apartment. The participants, representing eight Swedish consultancy firms, simulated the well-specified scenario with FDS 5. The participants received information about the build
This protocol details the induction of a hemogenic program in mouse embryonic fibroblasts (MEFs) via overexpression of transcription factors (TFs). We first designed a reporter screen using MEFs from human CD34-tTA/TetO-H2BGFP (34/H2BGFP) double transgenic mice. CD34+ cells from these mice label H2B histones with GFP, and cease labeling upon addition of doxycycline (DOX). MEFS were transduced with
We use the results from a recent investigation of hard parton-parton gravitational scattering in the ADD scenario to make semi-quantitative predictions for a few standard high-E-perpendicular to jet observables at the LHC. By implementing these gravitational scattering results in the PYTHIA event generator and combining it with the CHARYBDIS generator for black holes, we investigate the effects of
Objective. To determine the potential role of the CD24 A57V gene polymorphism in systemic lupus erythematosus (SLE). Methods. We studied 3 cohorts of Caucasian patients and controls. The Spanish cohort included 696 SLE patients and 539 controls, the German cohort included 257 SLE patients and 317 controls, and the Swedish cohort included 310 SLE patients and 247 controls. The CD24 A57V polymorphis
The purpose of the present article is to present an overview of a set of studies conducted in our own laboratory on cognitive and communicative development in children with cochlear implants (CI). The results demonstrate that children with CIs perform at significantly lower levels on the majority of the cognitive tasks. The exceptions to this trend are tasks with relatively lower demands on phonol
In this thesis we are evaluating Bluetooth Low Energy (BLE) v5.1 in combination with Direction Of Arrival (DOA) algorithms and receiving antenna arrays for indoor positioning systems. The thesis is divided in two parts. The first part is the core of the thesis and is composed by the evaluation of DOA algorithms in a direction finding system. A campaign of measurements is carried out in an active i
Med minskade resurser av fossila bränslen och ökade miljökrav har förnybara ersättningar fått större uppmärksamhet. Produktionen av förnybara kemikalier och bränslen genom förgasning av biomassa är en lovande lösning för att driva denna energiomställning. Syntesgas (syngas), en blandning av främst CO och H2, kan framställas av biomassa via förgasning. Biologisk me-tanisering, som ett potentiellt aWith reduced resources of fossil fuels and increased environmental requirements, renewable substitutes have received greater attention. The production of renewable chemicals and fuels through biomass gasification presents a promising route to drive this energy transition. Synthe-sis gas (syngas), a mixture of mainly CO and H2, can be produced from biomass via gasifica-tion. Biological methanation,
Titel: Constructing Yourself as a Female Manager: A qualitative analysis of how women construct their identities as Managers. Seminar date: 2/6 Course: FEKH49, Bachelor thesis in Management and Organisation, Undergraduate level, 15 University Credits Points. Authors: Sonia Jönsson, Nora Listrup, Johanna Schoug Supervisor: Anna Stevenson Keywords: Female Manager Identity, Female Manager Identi
This report addresses the related problems of trajectory generation and time-optimal path tracking with online obstacle avoidance. We consider the class of four-wheeled vehicles with independent steering and driving on each wheel, also referred to as pseudo-omnidirectional vehicles. Appropriate approximations of the dynamic model enable a convex reformulation of the path-tracking problem. Using th
We carried out a multistage genome-wide association study of type 2 diabetes mellitus in Japanese individuals, with a total of 1,612 cases and 1,424 controls and 100,000 SNPs. The most significant association was obtained with SNPs in KCNQ1, and dense mapping within the gene revealed that rs2237892 in intron 15 showed the lowest P value (6.7 x 10(-13), odds ratio (OR) = 1.49). The association of K
This study investigated cognitive performance in patients with burnout, in relation to the flexibility of the hypothalamic-pituitary-adrenal (HPA) axis. Clinical cases with work stress-induced burnout (n = 65), and demographically matched, healthy reference subjects (n = 65), were given six neuropsychological tests and a self-rating scale for cognitive problems. Diurnal salivary cortisol was measu
