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OBJECTIVE: To compare survival of patients with breast cancer who had never smoked, were smokers, and who were ex-smokers. DESIGN: Observational study. SETTING: City of Malmo, Sweden. PATIENTS: 792 patients with breast cancer diagnosed between 1977-1986 in the Malmo mammographic screening trial. INTERVENTIONS: Follow-up of breast cancer cases through record-linkage with the Swedish Cause of Death
The M protein of Streptococcus pyogenes is a major bacterial virulence factor that confers resistance to phagocytosis. To analyze how M protein allows evasion of phagocytosis, we used the M22 protein, which has features typical of many M proteins and has two well-characterized regions binding human plasma proteins: the hypervariable NH2-terminal region binds C4b-binding protein (C4BP), which inhib
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Popular Abstract in Swedish Elektroencefalogrammet (EEG), dvs mätning av potentialer på skalpen, är en relativt enkel och gammal teknik för att studera hjärnans aktivitet. Trots de stora framstegen inom s k brain-mapping-tekniker på senare år (magnetröntgen, PET, SPECT), är EEG fortfarande ett viktigt verktyg för diagnos. En av dess fördelar gentemot andra tekniker är dess fina tidsupplösning. EtThe thesis treats methods for pattern recognition in multichannel electroencephalogram (EEG) signals, for application to diagnostics of epilepsy. Parts I-IV treat methods for feature extraction and clustering of EEG spikes, occurring between epileptic seizures, and part V presents a method for filtering seizure onset EEG signals. In part I, Hermite functions are used for parametric description of
Excited states of nuclei in the vicinity of Sn-100 have been studied using: the EUROBALL detector array. Gamma-ray lines from Sn-103 have been identified for the first time, and a level scheme of low-lying excited states of Sn-103 has been established. New constraints on energies of single particle orbitals with respect to the Sn-100 core are obtained.
BACKGROUND:To investigate the dermal uptake of 4,4'-diphenylmethane diisocyanate (4,4'-MDI), a study was performed in which 2 female volunteers were exposed to 10 and 25 mg, respectively, of 4,4'-MDI by applying 2.0% 4,4'-MDI in petrolatum over areas where the surface concentration corresponded to 800 µg/cm(2) . Ten days later, they developed eczematous dermatitis at the area of application.OBJECT
Many changes have occurred in the area of immunity for high state officials during the last century. States and their High Representatives, such as Head of State, Head of Government and Foreign Ministers were at the beginning of the last century granted absolute immunities for all acts they conducted. Evolution has, however, produced new rules based more on their need to function properly and less
Popular Abstract in Swedish Hur gör bakterier för att komma undan immunförsvaret? Vi har studerat hur en vanligt förekommande bakterie, grupp A streptokocker, gör för att undvika kroppens immunförsvar vid infektion. Vi har upptäckt enzymer som bidrar till bakteriens förmåga att undvika immunförsvaret genom att avväpna antikroppar. De bakteriella enzymerna kan användas i bioteknisk industri och eveA majority of the proteins of the immune system are glycosylated and the glycans of IgG are essential for its functionality. Bacteria display enzymes that modulate the glycans of the immune system to weaken the host defense and favor bacterial survival. In this thesis we aimed at exploring bacterial modulation of host glycosylation in infection and to evaluate the usefulness of bacterial enzymes i
The aetiology of oral lichen lesions is obscure. In this study the frequency of contact allergy to gold in 83 patients with oral lichen lesions was compared with that in two control groups, comprising 319 age- and gender-matched patients with dermatitis selected from files and 83 clinically examined dermatitis patients. All patients were tested epicutaneously with gold sodium thiosulphate. The two
The interactions of biological macromolecules with nanoparticles underlie a wide variety of current and future applications in the fields of biotechnology, medicine and bioremediation. The same interactions are also responsible for mediating potential biohazards of nanomaterials. Some applications require that proteins adsorb to the nanomaterial and that the protein resists or undergoes structural
Osteoarthritis (OA) is a heterogeneous inflammatory joint disease that affects around 240-250 million people worldwide. The disease is a prominent cause of disability and a leading source of societal expenses in older adults. As of today, personalized OA treatment is considered essential and is currently being addressed in several osteoarthritis guidelines. To explore the possibilities of precisio
Objectives: The aim of the study was to illuminate the experience of life as next of kin to an elderly person with cancer. Background: Being next of kin to an elderly person with cancer and its impact on everyday life has been sparsely researched. Such understanding is needed to support both the sufferers and their relatives in dealing with issues arising after a cancer diagnosis in old age. Desig
With conventional antibiotic therapies being increasingly ineffective, bacterial infections with subsequent biofilm formation represent a global threat to human health. Here, an active and a passive strategy based on polymeric micelles were combined to fight bacterial growth. The passive strategy involved covalent immobilization of polymeric micelles through Michael addition between exposed maleim
Introduction: Carpal tunnel syndrome (CTS) is a common condition especially for people with diabetes, obesity or women who are pregnant. Diagnosing CTS has primarily been performed using electroneuronography. In this thesis the aim was to use an advanced method of tractography to measure and evaluate diffusion tensor imaging (DTI) parameters between anatomical landmarks at the distal radioulnar jo
